P21741: Midkine {ECO:0000303|PubMed:2025291}

General Information

Protein names	- Midkine {ECO:0000303\|PubMed:2025291} - MK {ECO:0000303\|PubMed:2025291} - Amphiregulin-associated protein {ECO:0000303\|PubMed:1883381} - ARAP {ECO:0000303\|PubMed:1883381} - Midgestation and kidney protein - Neurite outgrowth-promoting factor 2 - Neurite outgrowth-promoting protein {ECO:0000303\|PubMed:1768439}
Gene names	MDK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P21741

4 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT
        70         80         90        100        110        120
CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI
       130        140
RVTKPCTPKT KAKAKAKKGK GKD

Isoforms

- Isoform 2 of Midkine

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P21741-1-unknown	MQHRGF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81242
P21741-21-unknown	VAKKKD...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P21741-32-unknown	GPGSEC...	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17482
P21741-82-unknown	ADCKYK...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17483
P21741-82-unknown	ADCKYK...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18898
P21741-82-unknown	ADCKYK...	82	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196683

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KVKKGG	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17482
...KKEFGA	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17483
...KKEFGA	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18898
...GKGKD	143	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GKGKD	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76860

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	31	KKGG.\|.GPGS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	81	EFGA.\|.ADCK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	81	EFGA.\|.ADCK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)