P21741: Midkine {ECO:0000303|PubMed:2025291}
Protein names | - Midkine {ECO:0000303|PubMed:2025291} - MK {ECO:0000303|PubMed:2025291} - Amphiregulin-associated protein {ECO:0000303|PubMed:1883381} - ARAP {ECO:0000303|PubMed:1883381} - Midgestation and kidney protein - Neurite outgrowth-promoting factor 2 - Neurite outgrowth-promoting protein {ECO:0000303|PubMed:1768439} |
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Gene names | MDK |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P21741 |
4
N-termini
3
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT
70 80 90 100 110 120
CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI
130 140
RVTKPCTPKT KAKAKAKKGK GKD
Isoforms
- Isoform 2 of MidkineSequence View
10 20 30 40 50 60
MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT
70 80 90 100 110 120
CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI
130 140
RVTKPCTPKT KAKAKAKKGK GKD
Protein Neighborhood
Domains & Features
4 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P21741-1-unknown | MQHRGF... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt81242 | |||
P21741-21-unknown | VAKKKD... | 21 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P21741-32-unknown | GPGSEC... | 32 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17482 | |||
P21741-82-unknown | ADCKYK... | 82 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17483 | |||
P21741-82-unknown | ADCKYK... | 82 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18898 | |||
P21741-82-unknown | ADCKYK... | 82 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt196683 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...KVKKGG | 31 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17482 | |||
...KKEFGA | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17483 | |||
...KKEFGA | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18898 | |||
...GKGKD | 143 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...GKGKD | 143 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt76860 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MEP1A_HUMAN | 31 | KKGG.|.GPGS | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
MEP1A_HUMAN | 81 | EFGA.|.ADCK | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
MEP1B_HUMAN | 81 | EFGA.|.ADCK | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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