O15145: Actin-related protein 2/3 complex subunit 3

General Information

Protein names	- Actin-related protein 2/3 complex subunit 3 - Arp2/3 complex 21 kDa subunit - p21-ARC
Gene names	ARPC3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15145

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK ANVFFKNYEI
        70         80         90        100        110        120
KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI TNFPIPGEPG FPLNAIYAKP
       130        140        150        160        170
ANKQEDEVMR AYLQQLRQET GLRLCEKVFD PQNDKPSKWW TCFVKRQFMN KSLSGPGQ

Isoforms

Sequence View

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Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15145-2-unknown	PAYHSS...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15145-2-unknown	PAYHSS...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O15145-2-unknown	PAYHSS...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O15145-9-unknown	MDPDTK...	9	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446598
O15145-10-unknown	DPDTKL...	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18223
O15145-10-unknown	DPDTKL...	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16871
O15145-120-	PANKQE...	120		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HSSLMD	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18223
...HSSLMD	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16871
...KSQGEK	92	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446598
...SGPGQ	178	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	9	SLMD.\|.DPDT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	9	SLMD.\|.DPDT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)