TopFIND 4.0

Q15843: NEDD8

General Information

Protein names	- NEDD8 - Neddylin - Neural precursor cell expressed developmentally down-regulated protein 8 - NEDD-8 - Ubiquitin-like protein Nedd8
Gene names	NEDD8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15843

5

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK
70 80
ILGGSVLHLV LALRGGGGLR Q

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15843-1-unknown	MLIKVK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15843-17-unknown	IEPTDK...	17		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19589
Q15843-34-	EGIPPQ...	34			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15843-43-unknown	LIYSGK...	43			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15843-43-	LIYSGK...	43			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q15843-43-	LIYSGK...	43			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15843-43-	LIYSGK...	43			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...EIEIDI	16	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19589
	...SGKQMN	50	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000448192
	...ALRGGG	76	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...ALRGGG	76	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31592

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	16	EIDI.\|.IEPT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
SENP8_HUMAN	76	RGGG.\|.GGLR	inferred from experiment	unknown	MEROPS	Hay RT	Mendoza HM et al.:NEDP1, a highly conserved cyste... (C48.011)	12730221,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)