Q96LD8: Sentrin-specific protease 8

General Information

Protein names	- Sentrin-specific protease 8 - 3.4.22.- - Deneddylase-1 - NEDD8-specific protease 1 - Protease, cysteine 2 - Sentrin/SUMO-specific protease SENP8
Gene names	SENP8
Organism	Homo sapiens
Protease Family	C48.011
Protease ID	C48.011
Chromosome location
UniProt ID	Q96LD8

1 N-termini

4 C-termini

0 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MDPVVLSYMD SLLRQSDVSL LDPPSWLNDH IIGFAFEYFA NSQFHDCSDH VSFISPEVTQ
        70         80         90        100        110        120
FIKCTSNPAE IAMFLEPLDL PNKRVVFLAI NDNSNQAAGG THWSLLVYLQ DKNSFFHYDS
       130        140        150        160        170        180
HSRSNSVHAK QVAEKLEAFL GRKGDKLAFV EEKAPAQQNS YDCGMYVICN TEALCQNFFR
       190        200        210
QQTESLLQLL TPAYITKKRG EWKDLITTLA KK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

1 N-termini - 4 C-termini - 0 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96LD8-1-Acetylation	MDPVVL...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96LD8-1-Acetylation	MDPVVL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q96LD8-1-Acetylation	MDPVVL...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q96LD8-1-Acetylation	MDPVVL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GFAFEY	37	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457208
...AEIAMF	73	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000456567
...SVHAKQ	130	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457215
...TLAKK	212	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEDD8_HUMAN	76	RGGG.\|.GGLR	inferred from experiment	unknown	MEROPS	Hay RT	Mendoza HM et al.:NEDP1, a highly conserved cyste... (C48.011)	12730221,