P01130: Low-density lipoprotein receptor
Protein names | - Low-density lipoprotein receptor - LDL receptor |
---|---|
Gene names | LDLR |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P01130 |
3
N-termini
3
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
70 80 90 100 110 120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
130 140 150 160 170 180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
190 200 210 220 230 240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
250 260 270 280 290 300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
310 320 330 340 350 360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
370 380 390 400 410 420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
430 440 450 460 470 480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
490 500 510 520 530 540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
550 560 570 580 590 600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
610 620 630 640 650 660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
670 680 690 700 710 720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
730 740 750 760 770 780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
790 800 810 820 830 840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
850 860
NQDGYSYPSR QMVSLEDDVA
Isoforms
- Isoform 2 of Low-density lipoprotein receptor - Isoform 3 of Low-density lipoprotein receptor - Isoform 4 of Low-density lipoprotein receptor - Isoform 5 of Low-density lipoprotein receptor - Isoform 6 of Low-density lipoprotein receptor - Isoform 3 of Low-density lipoprotein receptorSequence View
10 20 30 40 50 60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
70 80 90 100 110 120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
130 140 150 160 170 180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
190 200 210 220 230 240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
250 260 270 280 290 300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
310 320 330 340 350 360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
370 380 390 400 410 420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
430 440 450 460 470 480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
490 500 510 520 530 540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
550 560 570 580 590 600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
610 620 630 640 650 660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
670 680 690 700 710 720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
730 740 750 760 770 780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
790 800 810 820 830 840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
850 860
NQDGYSYPSR QMVSLEDDVA
10 20 30 40 50 60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
70 80 90 100 110 120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
130 140 150 160 170 180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
190 200 210 220 230 240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
250 260 270 280 290 300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
310 320 330 340 350 360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
370 380 390 400 410 420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
430 440 450 460 470 480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
490 500 510 520 530 540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
550 560 570 580 590 600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
610 620 630 640 650 660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
670 680 690 700 710 720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
730 740 750 760 770 780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
790 800 810 820 830 840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
850 860
NQDGYSYPSR QMVSLEDDVA
10 20 30 40 50 60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
70 80 90 100 110 120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
130 140 150 160 170 180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
190 200 210 220 230 240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
250 260 270 280 290 300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
310 320 330 340 350 360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
370 380 390 400 410 420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
430 440 450 460 470 480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
490 500 510 520 530 540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
550 560 570 580 590 600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
610 620 630 640 650 660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
670 680 690 700 710 720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
730 740 750 760 770 780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
790 800 810 820 830 840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
850 860
NQDGYSYPSR QMVSLEDDVA
10 20 30 40 50 60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
70 80 90 100 110 120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
130 140 150 160 170 180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
190 200 210 220 230 240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
250 260 270 280 290 300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
310 320 330 340 350 360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
370 380 390 400 410 420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
430 440 450 460 470 480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
490 500 510 520 530 540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
550 560 570 580 590 600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
610 620 630 640 650 660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
670 680 690 700 710 720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
730 740 750 760 770 780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
790 800 810 820 830 840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
850 860
NQDGYSYPSR QMVSLEDDVA
10 20 30 40 50 60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
70 80 90 100 110 120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
130 140 150 160 170 180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
190 200 210 220 230 240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
250 260 270 280 290 300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
310 320 330 340 350 360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
370 380 390 400 410 420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
430 440 450 460 470 480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
490 500 510 520 530 540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
550 560 570 580 590 600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
610 620 630 640 650 660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
670 680 690 700 710 720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
730 740 750 760 770 780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
790 800 810 820 830 840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
850 860
NQDGYSYPSR QMVSLEDDVA
10 20 30 40 50 60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
70 80 90 100 110 120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
130 140 150 160 170 180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
190 200 210 220 230 240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
250 260 270 280 290 300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
310 320 330 340 350 360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
370 380 390 400 410 420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
430 440 450 460 470 480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
490 500 510 520 530 540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
550 560 570 580 590 600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
610 620 630 640 650 660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
670 680 690 700 710 720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
730 740 750 760 770 780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
790 800 810 820 830 840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
850 860
NQDGYSYPSR QMVSLEDDVA
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P01130-1-unknown | MGPWGW... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt79477 | |||
P01130-1-unknown | MGPWGW... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt79478 | |||
P01130-1-unknown | MGPWGW... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt79479 | |||
P01130-1-unknown | MGPWGW... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt79480 | |||
P01130-1-unknown | MGPWGW... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt79481 | |||
P01130-22-unknown | AVGDRC... | 22 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P01130-22-unknown | AVGDRC... | 22 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt113038 | |||
P01130-22-unknown | AVGDRC... | 22 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt113039 | |||
P01130-22-unknown | AVGDRC... | 22 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt113040 | |||
P01130-22-unknown | AVGDRC... | 22 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt113041 | |||
P01130-560-unknown | IQWPNG... | 560 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18352 | |||
P01130-560-unknown | IQWPNG... | 560 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt151896 | |||
P01130-560-unknown | IQWPNG... | 560 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152528 | |||
P01130-560-unknown | IQWPNG... | 560 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152625 | |||
P01130-560-unknown | IQWPNG... | 560 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153619 | |||
P01130-560-unknown | IQWPNG... | 560 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154117 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GLAVDW | 482 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000453513 | |||
...GLAVDW | 482 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt113029 | |||
...GLAVDW | 482 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt113028 | |||
...GLAVDW | 482 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt113032 | |||
...GLAVDW | 482 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt113030 | |||
...GLAVDW | 482 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt113031 | |||
...LVTENI | 559 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18352 | |||
...LVTENI | 559 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135304 | |||
...LVTENI | 559 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135939 | |||
...LVTENI | 559 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136042 | |||
...LVTENI | 559 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137042 | |||
...LVTENI | 559 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137537 | |||
...EDDVA | 860 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...EDDVA | 860 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt75095 | |||
...EDDVA | 860 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt75096 | |||
...EDDVA | 860 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt75099 | |||
...EDDVA | 860 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt75097 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MEP1B_HUMAN | 559 | TENI.|.IQWP | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|