P01130: Low-density lipoprotein receptor

General Information

Protein names	- Low-density lipoprotein receptor - LDL receptor
Gene names	LDLR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01130

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Low-density lipoprotein receptor - Isoform 3 of Low-density lipoprotein receptor - Isoform 4 of Low-density lipoprotein receptor - Isoform 5 of Low-density lipoprotein receptor - Isoform 6 of Low-density lipoprotein receptor - Isoform 3 of Low-density lipoprotein receptor

Sequence View

        10         20         30         40         50         60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
        70         80         90        100        110        120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
       130        140        150        160        170        180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
       190        200        210        220        230        240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
       250        260        270        280        290        300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
       310        320        330        340        350        360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
       370        380        390        400        410        420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
       430        440        450        460        470        480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
       490        500        510        520        530        540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
       550        560        570        580        590        600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
       610        620        630        640        650        660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
       670        680        690        700        710        720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
       730        740        750        760        770        780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
       790        800        810        820        830        840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
       850        860
NQDGYSYPSR QMVSLEDDVA         10         20         30         40         50         60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
        70         80         90        100        110        120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
       130        140        150        160        170        180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
       190        200        210        220        230        240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
       250        260        270        280        290        300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
       310        320        330        340        350        360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
       370        380        390        400        410        420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
       430        440        450        460        470        480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
       490        500        510        520        530        540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
       550        560        570        580        590        600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
       610        620        630        640        650        660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
       670        680        690        700        710        720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
       730        740        750        760        770        780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
       790        800        810        820        830        840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
       850        860
NQDGYSYPSR QMVSLEDDVA         10         20         30         40         50         60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
        70         80         90        100        110        120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
       130        140        150        160        170        180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
       190        200        210        220        230        240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
       250        260        270        280        290        300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
       310        320        330        340        350        360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
       370        380        390        400        410        420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
       430        440        450        460        470        480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
       490        500        510        520        530        540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
       550        560        570        580        590        600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
       610        620        630        640        650        660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
       670        680        690        700        710        720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
       730        740        750        760        770        780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
       790        800        810        820        830        840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
       850        860
NQDGYSYPSR QMVSLEDDVA         10         20         30         40         50         60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
        70         80         90        100        110        120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
       130        140        150        160        170        180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
       190        200        210        220        230        240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
       250        260        270        280        290        300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
       310        320        330        340        350        360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
       370        380        390        400        410        420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
       430        440        450        460        470        480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
       490        500        510        520        530        540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
       550        560        570        580        590        600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
       610        620        630        640        650        660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
       670        680        690        700        710        720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
       730        740        750        760        770        780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
       790        800        810        820        830        840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
       850        860
NQDGYSYPSR QMVSLEDDVA         10         20         30         40         50         60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
        70         80         90        100        110        120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
       130        140        150        160        170        180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
       190        200        210        220        230        240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
       250        260        270        280        290        300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
       310        320        330        340        350        360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
       370        380        390        400        410        420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
       430        440        450        460        470        480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
       490        500        510        520        530        540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
       550        560        570        580        590        600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
       610        620        630        640        650        660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
       670        680        690        700        710        720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
       730        740        750        760        770        780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
       790        800        810        820        830        840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
       850        860
NQDGYSYPSR QMVSLEDDVA         10         20         30         40         50         60
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
        70         80         90        100        110        120
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
       130        140        150        160        170        180
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
       190        200        210        220        230        240
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
       250        260        270        280        290        300
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
       310        320        330        340        350        360
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
       370        380        390        400        410        420
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
       430        440        450        460        470        480
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
       490        500        510        520        530        540
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
       550        560        570        580        590        600
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
       610        620        630        640        650        660
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
       670        680        690        700        710        720
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
       730        740        750        760        770        780
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
       790        800        810        820        830        840
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
       850        860
NQDGYSYPSR QMVSLEDDVA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01130-1-unknown	MGPWGW...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79477
P01130-1-unknown	MGPWGW...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79478
P01130-1-unknown	MGPWGW...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79479
P01130-1-unknown	MGPWGW...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79480
P01130-1-unknown	MGPWGW...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79481
P01130-22-unknown	AVGDRC...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01130-22-unknown	AVGDRC...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113038
P01130-22-unknown	AVGDRC...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113039
P01130-22-unknown	AVGDRC...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113040
P01130-22-unknown	AVGDRC...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113041
P01130-560-unknown	IQWPNG...	560	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18352
P01130-560-unknown	IQWPNG...	560	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151896
P01130-560-unknown	IQWPNG...	560	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152528
P01130-560-unknown	IQWPNG...	560	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152625
P01130-560-unknown	IQWPNG...	560	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153619
P01130-560-unknown	IQWPNG...	560	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154117

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GLAVDW	482	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453513
...GLAVDW	482	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113029
...GLAVDW	482	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113028
...GLAVDW	482	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113032
...GLAVDW	482	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113030
...GLAVDW	482	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113031
...LVTENI	559	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18352
...LVTENI	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135304
...LVTENI	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135939
...LVTENI	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136042
...LVTENI	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137042
...LVTENI	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137537
...EDDVA	860	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EDDVA	860	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75095
...EDDVA	860	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75096
...EDDVA	860	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75099
...EDDVA	860	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75097

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	559	TENI.\|.IQWP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)