P68133: Actin, alpha skeletal muscle

General Information

Protein names	- Actin, alpha skeletal muscle - Alpha-actin-1 - Actin, alpha skeletal muscle, intermediate form
Gene names	ACTA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P68133

14 N-termini

13 C-termini

16 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MCDEDETTAL VCDNGSGLVK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA
        70         80         90        100        110        120
QSKRGILTLK YPIEHGIITN WDDMEKIWHH TFYNELRVAP EEHPTLLTEA PLNPKANREK
       130        140        150        160        170        180
MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL
       190        200        210        220        230        240
DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK
       250        260        270        280        290        300
SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV
       310        320        330        340        350        360
MSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIT
       370
KQEYDEAGPS IVHRKCF

Isoforms

Sequence View

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P68133-3-Acetylation	DEDETT...	3	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P68133-3-Acetylation	DEDETT...	3	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P68133-5-	DETTAL...	5			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P68133-20-unknown	KAGFAG...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15348
P68133-21-unknown	AGFAGD...	21		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10156
P68133-50-unknown	GQKDSY...	50		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14297
P68133-50-unknown	GQKDSY...	50		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P68133-50-unknown	GQKDSY...	50		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P68133-54-unknown	SYVGDE...	54		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11805
P68133-54-unknown	SYVGDE...	54		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1981
P68133-108-unknown	TEAPLN...	108		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15349
P68133-109-unknown	EAPLNP...	109		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15350
P68133-186-unknown	DLTDYL...	186		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17811
P68133-219-unknown	CYVALD...	219		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14298
P68133-222-unknown	ALDFEN...	222		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15351
P68133-302-unknown	SGGTTM...	302		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6158
P68133-302-unknown	SGGTTM...	302		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3912
P68133-307-unknown	MYPGIA...	307		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6159
P68133-307-unknown	MYPGIA...	307		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7675
P68133-326-unknown	TMKIKI...	326		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19290
P68133-326-unknown	TMKIKI...	326		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17812

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GSGLVK	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15348
...SGLVKA	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10156
...VMVGMG	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14297
...MGQKDS	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11805
...MGQKDS	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1981
...HPTLLT	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15349
...PTLLTE	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15350
...DLAGRD	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17811
...IKEKLC	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14298
...KLCYVA	221	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15351
...ANNVMS	301	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6158
...ANNVMS	301	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3912
...SGGTTM	306	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6159
...SGGTTM	306	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7675
...ALAPST	325	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19290
...ALAPST	325	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17812
...HRKCF	377	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
HTRA2_HUMAN	19	GLVK.\|.KAGF	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	20	LVKA.\|.AGFA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	49	VGMG.\|.GQKD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	53	QKDS.\|.SYVG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP3_HUMAN	53	QKDS.\|.SYVG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
HTRA2_HUMAN	107	TLLT.\|.TEAP	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	108	LLTE.\|.EAPL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
MEP1A_HUMAN	185	AGRD.\|.DLTD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	218	EKLC.\|.CYVA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
HTRA2_HUMAN	221	CYVA.\|.ALDF	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
CATL1_HUMAN	301	NVMS.\|.SGGT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	301	NVMS.\|.SGGT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	306	GTTM.\|.MYPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	306	GTTM.\|.MYPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	325	APST.\|.TMKI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	325	APST.\|.TMKI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

TopFIND

P68133: Actin, alpha skeletal muscle

General Information

14

N-termini

13

C-termini

16

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

14 N-termini - 13 C-termini - 16 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates