O00151: PDZ and LIM domain protein 1

General Information

Protein names	- PDZ and LIM domain protein 1 - C-terminal LIM domain protein 1 - Elfin - LIM domain protein CLP-36
Gene names	PDLIM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00151

22 N-termini

11 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTTQQIDLQG PGPWGFRLVG GKDFEQPLAI SRVTPGSKAA LANLCIGDVI TAIDGENTSN
        70         80         90        100        110        120
MTHLEAQNRI KGCTDNLTLT VARSEHKVWS PLVTEEGKRH PYKMNLASEP QEVLHIGSAH
       130        140        150        160        170        180
NRSAMPFTAS PASSTTARVI TNQYNNPAGL YSSENISNFN NALESKTAAS GVEANSRPLD
       190        200        210        220        230        240
HAQPPSSLVI DKESEVYKML QEKQELNEPP KQSTSFLVLQ EILESEEKGD PNKPSGFRSV
       250        260        270        280        290        300
KAPVTKVAAS IGNAQKLPMC DKCGTGIVGV FVKLRDRHRH PECYVCTDCG TNLKQKGHFF
       310        320
VEDQIYCEKH ARERVTPPEG YEVVTVFPK

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

22 N-termini - 11 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00151-2-unknown	MTTQQI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00151-2-Acetylation	TTQQID...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00151-2-Acetylation	TTQQID...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O00151-55-	GENTSN...	55			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00151-55-	GENTSN...	55			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00151-55-	GENTSN...	55			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00151-90-unknown	SPLVTE...	90		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18195
O00151-90-unknown	SPLVTE...	90		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16851
O00151-108-	SEPQEV...	108			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00151-109-unknown	EPQEVL...	109		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18196
O00151-123-	SAMPFT...	123			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O00151-123-	SAMPFT...	123			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00151-124-	AMPFTA...	124			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O00151-124-	AMPFTA...	124			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O00151-124-	AMPFTA...	124			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00151-152-	SSENIS...	152			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00151-182-	AQPPSS...	182			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O00151-182-	AQPPSS...	182			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00151-182-	AQPPSS...	182			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O00151-182-	AQPPSS...	182			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O00151-182-	AQPPSS...	182			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00151-188-unknown	LVIDKE...	188		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18197
O00151-213-unknown	STSFLV...	213		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18198
O00151-213-unknown	STSFLV...	213		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16852
O00151-214-unknown	TSFLVL...	214		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16853
O00151-218-unknown	VLQEIL...	218		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16854
O00151-221-unknown	EILESE...	221		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16855
O00151-239-	SVKAPV...	239			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00151-242-	APVTKV...	242			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O00151-247-unknown	VAASIG...	247			unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
O00151-247-	VAASIG...	247			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00151-249-unknown	ASIGNA...	249			unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
O00151-272-unknown	VKLRDR...	272		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1079
O00151-303-unknown	DQIYCE...	303		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18199
O00151-303-unknown	DQIYCE...	303		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16856

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EHKVWS	89	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18195
...EHKVWS	89	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16851
...MNLASE	108	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18196
...QPPSSL	187	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18197
...EPPKQS	212	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18198
...EPPKQS	212	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16852
...PPKQST	213	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16853
...STSFLV	217	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16854
...FLVLQE	220	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16855
...IVGVFV	271	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1079
...HFFVED	302	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18199
...HFFVED	302	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16856
...TVFPK	329		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TVFPK	329		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...TVFPK	329	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...TVFPK	329		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TVFPK	329		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	89	KVWS.\|.SPLV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	89	KVWS.\|.SPLV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	108	LASE.\|.EPQE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	187	PSSL.\|.LVID	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	212	PKQS.\|.STSF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	212	PKQS.\|.STSF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	213	KQST.\|.TSFL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	217	SFLV.\|.VLQE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	220	VLQE.\|.EILE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CAN3_HUMAN	271	GVFV.\|.VKLR	inferred from experiment	unknown	MEROPS	Carafoli E	Bertipaglia I et al.:A proteomic study of calpain-3 ... (C02.004)	19926129,
MEP1B_HUMAN	302	FVED.\|.DQIY	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	302	FVED.\|.DQIY	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)