P20807: Calpain-3
Protein names | - Calpain-3 - 3.4.22.54 - Calcium-activated neutral proteinase 3 - CANP 3 - Calpain L3 - Calpain p94 - Muscle-specific calcium-activated neutral protease 3 - New calpain 1 - nCL-1 |
---|---|
Gene names | CAPN3 |
Organism | Homo sapiens |
Protease Family | C02.004 |
Protease ID | C02.004 |
Chromosome location | |
UniProt ID | P20807 |
3
N-termini
1
C-termini
0
Cleavages
1
Substrates
Sequence
10 20 30 40 50 60
MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN FPIIGVKEKT
70 80 90 100 110 120
FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIIDGANRTD
130 140 150 160 170 180
ICQGELGDCW FLAAIACLTL NQHLLFRVIP HDQSFIENYA GIFHFQFWRY GEWVDVVIDD
190 200 210 220 230 240
CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE
250 260 270 280 290 300
IRDAPSDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ
310 320 330 340 350 360
DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK VKLVRLRNPW
370 380 390 400 410 420
GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS YEDFIYHFTK LEICNLTADA
430 440 450 460 470 480
LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD PDDSEVICSF
490 500 510 520 530 540
LVALMQKNRR KDRKLGASLF TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM
550 560 570 580 590 600
REVSQRFRLP PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK
610 620 630 640 650 660
PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE QQQFRNIFKQ
670 680 690 700 710 720
IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM IALMDTDGSG KLNLQEFHHL
730 740 750 760 770 780
WNKIKAWQKI FKHYDTDQSG TINSYEMRNA VNDAGFHLNN QLYDIITMRY ADKHMNIDFD
790 800 810 820
SFICCFVRLE GMFRAFHAFD KDGDGIIKLN VLEWLQLTMY A
Isoforms
- Isoform II of Calpain-3 - Isoform III of Calpain-3 - Isoform IV of Calpain-3 - Isoform V of Calpain-3Sequence View
10 20 30 40 50 60
MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN FPIIGVKEKT
70 80 90 100 110 120
FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIIDGANRTD
130 140 150 160 170 180
ICQGELGDCW FLAAIACLTL NQHLLFRVIP HDQSFIENYA GIFHFQFWRY GEWVDVVIDD
190 200 210 220 230 240
CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE
250 260 270 280 290 300
IRDAPSDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ
310 320 330 340 350 360
DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK VKLVRLRNPW
370 380 390 400 410 420
GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS YEDFIYHFTK LEICNLTADA
430 440 450 460 470 480
LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD PDDSEVICSF
490 500 510 520 530 540
LVALMQKNRR KDRKLGASLF TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM
550 560 570 580 590 600
REVSQRFRLP PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK
610 620 630 640 650 660
PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE QQQFRNIFKQ
670 680 690 700 710 720
IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM IALMDTDGSG KLNLQEFHHL
730 740 750 760 770 780
WNKIKAWQKI FKHYDTDQSG TINSYEMRNA VNDAGFHLNN QLYDIITMRY ADKHMNIDFD
790 800 810 820
SFICCFVRLE GMFRAFHAFD KDGDGIIKLN VLEWLQLTMY A
10 20 30 40 50 60
MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN FPIIGVKEKT
70 80 90 100 110 120
FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIIDGANRTD
130 140 150 160 170 180
ICQGELGDCW FLAAIACLTL NQHLLFRVIP HDQSFIENYA GIFHFQFWRY GEWVDVVIDD
190 200 210 220 230 240
CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE
250 260 270 280 290 300
IRDAPSDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ
310 320 330 340 350 360
DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK VKLVRLRNPW
370 380 390 400 410 420
GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS YEDFIYHFTK LEICNLTADA
430 440 450 460 470 480
LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD PDDSEVICSF
490 500 510 520 530 540
LVALMQKNRR KDRKLGASLF TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM
550 560 570 580 590 600
REVSQRFRLP PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK
610 620 630 640 650 660
PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE QQQFRNIFKQ
670 680 690 700 710 720
IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM IALMDTDGSG KLNLQEFHHL
730 740 750 760 770 780
WNKIKAWQKI FKHYDTDQSG TINSYEMRNA VNDAGFHLNN QLYDIITMRY ADKHMNIDFD
790 800 810 820
SFICCFVRLE GMFRAFHAFD KDGDGIIKLN VLEWLQLTMY A
10 20 30 40 50 60
MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN FPIIGVKEKT
70 80 90 100 110 120
FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIIDGANRTD
130 140 150 160 170 180
ICQGELGDCW FLAAIACLTL NQHLLFRVIP HDQSFIENYA GIFHFQFWRY GEWVDVVIDD
190 200 210 220 230 240
CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE
250 260 270 280 290 300
IRDAPSDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ
310 320 330 340 350 360
DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK VKLVRLRNPW
370 380 390 400 410 420
GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS YEDFIYHFTK LEICNLTADA
430 440 450 460 470 480
LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD PDDSEVICSF
490 500 510 520 530 540
LVALMQKNRR KDRKLGASLF TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM
550 560 570 580 590 600
REVSQRFRLP PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK
610 620 630 640 650 660
PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE QQQFRNIFKQ
670 680 690 700 710 720
IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM IALMDTDGSG KLNLQEFHHL
730 740 750 760 770 780
WNKIKAWQKI FKHYDTDQSG TINSYEMRNA VNDAGFHLNN QLYDIITMRY ADKHMNIDFD
790 800 810 820
SFICCFVRLE GMFRAFHAFD KDGDGIIKLN VLEWLQLTMY A
10 20 30 40 50 60
MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN FPIIGVKEKT
70 80 90 100 110 120
FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIIDGANRTD
130 140 150 160 170 180
ICQGELGDCW FLAAIACLTL NQHLLFRVIP HDQSFIENYA GIFHFQFWRY GEWVDVVIDD
190 200 210 220 230 240
CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE
250 260 270 280 290 300
IRDAPSDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ
310 320 330 340 350 360
DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK VKLVRLRNPW
370 380 390 400 410 420
GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS YEDFIYHFTK LEICNLTADA
430 440 450 460 470 480
LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD PDDSEVICSF
490 500 510 520 530 540
LVALMQKNRR KDRKLGASLF TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM
550 560 570 580 590 600
REVSQRFRLP PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK
610 620 630 640 650 660
PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE QQQFRNIFKQ
670 680 690 700 710 720
IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM IALMDTDGSG KLNLQEFHHL
730 740 750 760 770 780
WNKIKAWQKI FKHYDTDQSG TINSYEMRNA VNDAGFHLNN QLYDIITMRY ADKHMNIDFD
790 800 810 820
SFICCFVRLE GMFRAFHAFD KDGDGIIKLN VLEWLQLTMY A
Protein Neighborhood
Domains & Features
3 N-termini - 1 C-termini - 0 Cleavages - 1 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P20807-1-unknown | MPTVIS... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P20807-1-unknown | MPTVIS... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt69245 | |||
P20807-1-unknown | MPTVIS... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt69246 | |||
P20807-513-unknown | MHGNKQ... | 513 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt69247 | |||
P20807-513-unknown | MHGNKQ... | 513 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt103088 | |||
P20807-513-unknown | MHGNKQ... | 513 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt103087 | |||
P20807-666-unknown | MEICAD... | 666 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt69248 | |||
P20807-666-unknown | MEICAD... | 666 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt103144 | |||
P20807-666-unknown | MEICAD... | 666 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt103146 | |||
P20807-666-unknown | MEICAD... | 666 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt103145 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LTMYA | 821 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...LTMYA | 821 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt64866 | |||
...LTMYA | 821 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt64865 | |||
...LTMYA | 821 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt64863 | |||
...LTMYA | 821 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt64864 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
PDLI1_HUMAN | 271 | GVFV.|.VKLR | inferred from experiment | unknown | MEROPS | Carafoli E | Bertipaglia I et al.:A proteomic study of calpain-3 ... (C02.004) | 19926129, |