P20807: Calpain-3

General Information

Protein names	- Calpain-3 - 3.4.22.54 - Calcium-activated neutral proteinase 3 - CANP 3 - Calpain L3 - Calpain p94 - Muscle-specific calcium-activated neutral protease 3 - New calpain 1 - nCL-1
Gene names	CAPN3
Organism	Homo sapiens
Protease Family	C02.004
Protease ID	C02.004
Chromosome location
UniProt ID	P20807

3 N-termini

1 C-termini

0 Cleavages

1 Substrates

Sequence

Isoforms

- Isoform II of Calpain-3 - Isoform III of Calpain-3 - Isoform IV of Calpain-3 - Isoform V of Calpain-3

Sequence View

        10         20         30         40         50         60
MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN FPIIGVKEKT
        70         80         90        100        110        120
FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIIDGANRTD
       130        140        150        160        170        180
ICQGELGDCW FLAAIACLTL NQHLLFRVIP HDQSFIENYA GIFHFQFWRY GEWVDVVIDD
       190        200        210        220        230        240
CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE
       250        260        270        280        290        300
IRDAPSDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ
       310        320        330        340        350        360
DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK VKLVRLRNPW
       370        380        390        400        410        420
GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS YEDFIYHFTK LEICNLTADA
       430        440        450        460        470        480
LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD PDDSEVICSF
       490        500        510        520        530        540
LVALMQKNRR KDRKLGASLF TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM
       550        560        570        580        590        600
REVSQRFRLP PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK
       610        620        630        640        650        660
PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE QQQFRNIFKQ
       670        680        690        700        710        720
IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM IALMDTDGSG KLNLQEFHHL
       730        740        750        760        770        780
WNKIKAWQKI FKHYDTDQSG TINSYEMRNA VNDAGFHLNN QLYDIITMRY ADKHMNIDFD
       790        800        810        820
SFICCFVRLE GMFRAFHAFD KDGDGIIKLN VLEWLQLTMY A         10         20         30         40         50         60
MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN FPIIGVKEKT
        70         80         90        100        110        120
FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIIDGANRTD
       130        140        150        160        170        180
ICQGELGDCW FLAAIACLTL NQHLLFRVIP HDQSFIENYA GIFHFQFWRY GEWVDVVIDD
       190        200        210        220        230        240
CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE
       250        260        270        280        290        300
IRDAPSDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ
       310        320        330        340        350        360
DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK VKLVRLRNPW
       370        380        390        400        410        420
GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS YEDFIYHFTK LEICNLTADA
       430        440        450        460        470        480
LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD PDDSEVICSF
       490        500        510        520        530        540
LVALMQKNRR KDRKLGASLF TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM
       550        560        570        580        590        600
REVSQRFRLP PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK
       610        620        630        640        650        660
PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE QQQFRNIFKQ
       670        680        690        700        710        720
IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM IALMDTDGSG KLNLQEFHHL
       730        740        750        760        770        780
WNKIKAWQKI FKHYDTDQSG TINSYEMRNA VNDAGFHLNN QLYDIITMRY ADKHMNIDFD
       790        800        810        820
SFICCFVRLE GMFRAFHAFD KDGDGIIKLN VLEWLQLTMY A         10         20         30         40         50         60
MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN FPIIGVKEKT
        70         80         90        100        110        120
FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIIDGANRTD
       130        140        150        160        170        180
ICQGELGDCW FLAAIACLTL NQHLLFRVIP HDQSFIENYA GIFHFQFWRY GEWVDVVIDD
       190        200        210        220        230        240
CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE
       250        260        270        280        290        300
IRDAPSDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ
       310        320        330        340        350        360
DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK VKLVRLRNPW
       370        380        390        400        410        420
GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS YEDFIYHFTK LEICNLTADA
       430        440        450        460        470        480
LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD PDDSEVICSF
       490        500        510        520        530        540
LVALMQKNRR KDRKLGASLF TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM
       550        560        570        580        590        600
REVSQRFRLP PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK
       610        620        630        640        650        660
PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE QQQFRNIFKQ
       670        680        690        700        710        720
IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM IALMDTDGSG KLNLQEFHHL
       730        740        750        760        770        780
WNKIKAWQKI FKHYDTDQSG TINSYEMRNA VNDAGFHLNN QLYDIITMRY ADKHMNIDFD
       790        800        810        820
SFICCFVRLE GMFRAFHAFD KDGDGIIKLN VLEWLQLTMY A         10         20         30         40         50         60
MPTVISASVA PRTAAEPRSP GPVPHPAQSK ATEAGGGNPS GIYSAIISRN FPIIGVKEKT
        70         80         90        100        110        120
FEQLHKKCLE KKVLYVDPEF PPDETSLFYS QKFPIQFVWK RPPEICENPR FIIDGANRTD
       130        140        150        160        170        180
ICQGELGDCW FLAAIACLTL NQHLLFRVIP HDQSFIENYA GIFHFQFWRY GEWVDVVIDD
       190        200        210        220        230        240
CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK GGNTTEAMED FTGGVAEFFE
       250        260        270        280        290        300
IRDAPSDMYK IMKKAIERGS LMGCSIDDGT NMTYGTSPSG LNMGELIARM VRNMDNSLLQ
       310        320        330        340        350        360
DSDLDPRGSD ERPTRTIIPV QYETRMACGL VRGHAYSVTG LDEVPFKGEK VKLVRLRNPW
       370        380        390        400        410        420
GQVEWNGSWS DRWKDWSFVD KDEKARLQHQ VTEDGEFWMS YEDFIYHFTK LEICNLTADA
       430        440        450        460        470        480
LQSDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD PDDSEVICSF
       490        500        510        520        530        540
LVALMQKNRR KDRKLGASLF TIGFAIYEVP KEMHGNKQHL QKDFFLYNAS KARSKTYINM
       550        560        570        580        590        600
REVSQRFRLP PSEYVIVPST YEPHQEGEFI LRVFSEKRNL SEEVENTISV DRPVKKKKTK
       610        620        630        640        650        660
PIIFVSDRAN SNKELGVDQE SEEGKGKTSP DKQKQSPQPQ PGSSDQESEE QQQFRNIFKQ
       670        680        690        700        710        720
IAGDDMEICA DELKKVLNTV VNKHKDLKTH GFTLESCRSM IALMDTDGSG KLNLQEFHHL
       730        740        750        760        770        780
WNKIKAWQKI FKHYDTDQSG TINSYEMRNA VNDAGFHLNN QLYDIITMRY ADKHMNIDFD
       790        800        810        820
SFICCFVRLE GMFRAFHAFD KDGDGIIKLN VLEWLQLTMY A

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P20807-1-unknown	MPTVIS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20807-1-unknown	MPTVIS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69245
P20807-1-unknown	MPTVIS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69246
P20807-513-unknown	MHGNKQ...	513	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69247
P20807-513-unknown	MHGNKQ...	513	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103088
P20807-513-unknown	MHGNKQ...	513	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103087
P20807-666-unknown	MEICAD...	666	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69248
P20807-666-unknown	MEICAD...	666	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103144
P20807-666-unknown	MEICAD...	666	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103146
P20807-666-unknown	MEICAD...	666	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103145

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LTMYA	821	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LTMYA	821	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64866
...LTMYA	821	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64865
...LTMYA	821	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64863
...LTMYA	821	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64864

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PDLI1_HUMAN	271	GVFV.\|.VKLR	inferred from experiment	unknown	MEROPS	Carafoli E	Bertipaglia I et al.:A proteomic study of calpain-3 ... (C02.004)	19926129,