Q92945: Far upstream element-binding protein 2

General Information

Protein names	- Far upstream element-binding protein 2 - FUSE-binding protein 2 - KH type-splicing regulatory protein - KSRP - p75
Gene names	KHSRP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92945

43 N-termini

30 C-termini

33 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSDYSTGGPP PGPPPPAGGG GGAGGAGGGP PPGPPGAGDR GGGGPGGGGP GGGSAGGPSQ
        70         80         90        100        110        120
PPGGGGPGIR KDAFADAVQR ARQIAAKIGG DAATTVNNST PDFGFGGQKR QLEDGDQPES
       130        140        150        160        170        180
KKLASQGDSI SSQLGPIHPP PRTSMTEEYR VPDGMVGLII GRGGEQINKI QQDSGCKVQI
       190        200        210        220        230        240
SPDSGGLPER SVSLTGAPES VQKAKMMLDD IVSRGRGGPP GQFHDNANGG QNGTVQEIMI
       250        260        270        280        290        300
PAGKAGLVIG KGGETIKQLQ ERAGVKMILI QDGSQNTNVD KPLRIIGDPY KVQQACEMVM
       310        320        330        340        350        360
DILRERDQGG FGDRNEYGSR IGGGIDVPVP RHSVGVVIGR SGEMIKKIQN DAGVRIQFKQ
       370        380        390        400        410        420
DDGTGPEKIA HIMGPPDRCE HAARIINDLL QSLRSGPPGP PGGPGMPPGG RGRGRGQGNW
       430        440        450        460        470        480
GPPGGEMTFS IPTHKCGLVI GRGGENVKAI NQQTGAFVEI SRQLPPNGDP NFKLFIIRGS
       490        500        510        520        530        540
PQQIDHAKQL IEEKIEGPLC PVGPGPGGPG PAGPMGPFNP GPFNQGPPGA PPHAGGPPPH
       550        560        570        580        590        600
QYPPQGWGNT YPQWQPPAPH DPSKAAAAAA DPNAAWAAYY SHYYQQPPGP VPGPAPAPAA
       610        620        630        640        650        660
PPAQGEPPQP PPTGQSDYTK AWEEYYKKIG QQPQQPGAPP QQDYTKAWEE YYKKQAQVAT
       670        680        690        700        710
GGGPGAPPGS QPDYSAAWAE YYRQQAAYYG QTPGPGGPQP PPTQQGQQQA Q

Isoforms

Sequence View

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Physiological Relevance:

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

43 N-termini - 30 C-termini - 33 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q92945-2-unknown	MSDYST...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92945-2-Acetylation	SDYSTG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92945-2-Acetylation	SDYSTG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q92945-2-Acetylation	SDYSTG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q92945-2-Acetylation	SDYSTG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q92945-25-unknown	GAGGGP...	25		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4175
Q92945-71-	KDAFAD...	71			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q92945-71-	KDAFAD...	71			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q92945-71-	KDAFAD...	71			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q92945-71-unknown	KDAFAD...	71			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92945-71-unknown	KDAFAD...	71			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92945-73-unknown	AFADAV...	73		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2283
Q92945-77-unknown	AVQRAR...	77		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2284
Q92945-92-unknown	AATTVN...	92		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13025
Q92945-92-unknown	AATTVN...	92		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2285
Q92945-99-	STPDFG...	99			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q92945-99-	STPDFG...	99			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92945-99-	STPDFG...	99			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q92945-99-	STPDFG...	99			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q92945-99-unknown	STPDFG...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19724
Q92945-100-unknown	TPDFGF...	100		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18064
Q92945-103-	FGFGGQ...	103			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q92945-103-unknown	FGFGGQ...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18065
Q92945-103-unknown	FGFGGQ...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2286
Q92945-115-unknown	GDQPES...	115		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2287
Q92945-117-unknown	QPESKK...	117		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2288
Q92945-122-	KLASQG...	122			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q92945-122-	KLASQG...	122			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q92945-128-unknown	DSISSQ...	128		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19725
Q92945-129-	SISSQL...	129			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q92945-129-	SISSQL...	129			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q92945-129-	SISSQL...	129			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q92945-129-	SISSQL...	129			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q92945-129-	SISSQL...	129			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q92945-129-	SISSQL...	129			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92945-129-	SISSQL...	129			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q92945-129-	SISSQL...	129			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q92945-129-	SISSQL...	129			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
Q92945-129-	SISSQL...	129			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q92945-129-unknown	SISSQL...	129		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1337
Q92945-129-unknown	SISSQL...	129		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2289
Q92945-129-unknown	SISSQL...	129			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92945-129-unknown	SISSQL...	129			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92945-132-unknown	SQLGPI...	132		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7991
Q92945-132-unknown	SQLGPI...	132		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6637
Q92945-134-unknown	LGPIHP...	134		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4176
Q92945-134-unknown	LGPIHP...	134		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18066
Q92945-145-unknown	MTEEYR...	145		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000469830
Q92945-145-unknown	MTEEYR...	145		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000469431
Q92945-147-unknown	EEYRVP...	147		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q92945-174-unknown	SGCKVQ...	174		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13026
Q92945-184-	SGGLPE...	184			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q92945-184-unknown	SGGLPE...	184		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13027
Q92945-194-unknown	LTGAPE...	194		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4177
Q92945-196-unknown	GAPESV...	196		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6638
Q92945-206-	MMLDDI...	206			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q92945-206-	MMLDDI...	206			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q92945-206-	MMLDDI...	206			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q92945-233-	GTVQEI...	233			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q92945-245-	AGLVIG...	245			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q92945-267-	MILIQD...	267			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92945-267-	MILIQD...	267			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q92945-267-	MILIQD...	267			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q92945-268-unknown	ILIQDG...	268		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4178
Q92945-270-unknown	IQDGSQ...	270		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6639
Q92945-271-unknown	QDGSQN...	271		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6640
Q92945-272-unknown	DGSQNT...	272		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7992
Q92945-272-unknown	DGSQNT...	272		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4179
Q92945-272-unknown	DGSQNT...	272		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6641
Q92945-273-unknown	GSQNTN...	273		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4180
Q92945-479-unknown	GSPQQI...	479		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6642
Q92945-549-unknown	NTYPQW...	549		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6643
Q92945-554-unknown	WQPPAP...	554		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6644
Q92945-580-unknown	YSHYYQ...	580		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000472347
Q92945-631-unknown	QQPQQP...	631		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7993
Q92945-659-	ATGGGP...	659			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GGGAGG	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4175
...GIRKDA	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2283
...DAFADA	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2284
...KIGGDA	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13025
...KIGGDA	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2285
...TTVNNS	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19724
...TVNNST	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18064
...NSTPDF	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18065
...NSTPDF	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2286
...RQLEDG	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2287
...LEDGDQ	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2288
...LASQGD	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19725
...ASQGDS	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1337
...ASQGDS	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2289
...GDSISS	131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7991
...GDSISS	131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6637
...SISSQL	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4176
...SISSQL	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18066
...KIQQDS	173	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13026
...QISPDS	183	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13027
...ERSVSL	193	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4177
...SVSLTG	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6638
...IKQLQE	260	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469431
...AGVKMI	267	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4178
...VKMILI	269	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6639
...KMILIQ	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6640
...MILIQD	271	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7992
...MILIQD	271	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4179
...MILIQD	271	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6641
...ILIQDG	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4180
...GGFGDR	313	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469830
...IQFKQD	360	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471262
...LFIIRG	478	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6642
...PQGWGN	548	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6643
...NTYPQW	553	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6644
...YKKIGQ	630	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7993
...QQQAQ	711	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	24	GAGG.\|.GAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP3_HUMAN	72	RKDA.\|.AFAD	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
CASP3_HUMAN	76	FADA.\|.AVQR	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
GRAB_HUMAN	91	GGDA.\|.AATT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP3_HUMAN	91	GGDA.\|.AATT	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
MEP1B_HUMAN	98	VNNS.\|.STPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	99	NNST.\|.TPDF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	102	TPDF.\|.FGFG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP3_HUMAN	102	TPDF.\|.FGFG	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
CASP3_HUMAN	114	LEDG.\|.GDQP	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
CASP3_HUMAN	116	DGDQ.\|.QPES	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
MEP1B_HUMAN	127	SQGD.\|.DSIS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP1_HUMAN	128	QGDS.\|.SISS	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CASP3_HUMAN	128	QGDS.\|.SISS	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
CATS_HUMAN	131	SISS.\|.SQLG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	131	SISS.\|.SQLG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	133	SSQL.\|.LGPI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	133	SSQL.\|.LGPI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	173	QQDS.\|.SGCK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	183	SPDS.\|.SGGL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATB_HUMAN	193	SVSL.\|.LTGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	195	SLTG.\|.GAPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	267	VKMI.\|.ILIQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	269	MILI.\|.IQDG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	270	ILIQ.\|.QDGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	271	LIQD.\|.DGSQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	271	LIQD.\|.DGSQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	271	LIQD.\|.DGSQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	272	IQDG.\|.GSQN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	478	IIRG.\|.GSPQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	548	GWGN.\|.NTYP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	553	YPQW.\|.WQPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	630	KIGQ.\|.QQPQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)