P43490: Nicotinamide phosphoribosyltransferase

General Information

Protein names	- Nicotinamide phosphoribosyltransferase - NAmPRTase - Nampt - 2.4.2.12 - Pre-B-cell colony-enhancing factor 1 - Pre-B cell-enhancing factor - Visfatin
Gene names	NAMPT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P43490

3 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNPAAEAEFN ILLATDSYKV THYKQYPPNT SKVYSYFECR EKKTENSKLR KVKYEETVFY
        70         80         90        100        110        120
GLQYILNKYL KGKVVTKEKI QEAKDVYKEH FQDDVFNEKG WNYILEKYDG HLPIEIKAVP
       130        140        150        160        170        180
EGFVIPRGNV LFTVENTDPE CYWLTNWIET ILVQSWYPIT VATNSREQKK ILAKYLLETS
       190        200        210        220        230        240
GNLDGLEYKL HDFGYRGVSS QETAGIGASA HLVNFKGTDT VAGLALIKKY YGTKDPVPGY
       250        260        270        280        290        300
SVPAAEHSTI TAWGKDHEKD AFEHIVTQFS SVPVSVVSDS YDIYNACEKI WGEDLRHLIV
       310        320        330        340        350        360
SRSTQAPLII RPDSGNPLDT VLKVLEILGK KFPVTENSKG YKLLPPYLRV IQGDGVDINT
       370        380        390        400        410        420
LQEIVEGMKQ KMWSIENIAF GSGGGLLQKL TRDLLNCSFK CSYVVTNGLG INVFKDPVAD
       430        440        450        460        470        480
PNKRSKKGRL SLHRTPAGNF VTLEEGKGDL EEYGQDLLHT VFKNGKVTKS YSFDEIRKNA
       490
QLNIELEAAH H

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P43490-1-Acetylation	MNPAAE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P43490-1-Acetylation	MNPAAE...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P43490-210-unknown	AHLVNF...	210		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11520
P43490-279-unknown	DSYDIY...	279		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19108
P43490-279-unknown	DSYDIY...	279		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17650

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ETVFYG	60	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390896
...KDVYKE	88	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390591
...GIGASA	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11520
...VSVVSD	278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19108
...VSVVSD	278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17650
...EAAHH	491	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	209	GASA.\|.AHLV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1B_HUMAN	278	VVSD.\|.DSYD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	278	VVSD.\|.DSYD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)