P39060: Collagen alpha-1(XVIII) chain

General Information

Protein names	- Collagen alpha-1(XVIII) chain - Endostatin - Non-collagenous domain 1 - NC1
Gene names	COL18A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P39060

13 N-termini

9 C-termini

13 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Collagen alpha-1(XVIII) chain - Isoform 3 of Collagen alpha-1(XVIII) chain

Sequence View

        10         20         30         40         50         60
MAPYPCGCHI LLLLFCCLAA ARANLLNLNW LWFNNEDTSH AATTIPEPQG PLPVQPTADT
        70         80         90        100        110        120
TTHVTPRNGS TEPATAPGSP EPPSELLEDG QDTPTSAESP DAPEENIAGV GAEILNVAKG
       130        140        150        160        170        180
IRSFVQLWND TVPTESLARA ETLVLETPVG PLALAGPSST PQENGTTLWP SRGIPSSPGA
       190        200        210        220        230        240
HTTEAGTLPA PTPSPPSLGR PWAPLTGPSV PPPSSGRASL SSLLGGAPPW GSLQDPDSQG
       250        260        270        280        290        300
LSPAAAAPSQ QLQRPDVRLR TPLLHPLVMG SLGKHAAPSA FSSGLPGALS QVAVTTLTRD
       310        320        330        340        350        360
SGAWVSHVAN SVGPGLANNS ALLGADPEAP AGRCLPLPPS LPVCGHLGIS RFWLPNHLHH
       370        380        390        400        410        420
ESGEQVRAGA RAWGGLLQTH CHPFLAWFFC LLLVPPCGSV PPPAPPPCCQ FCEALQDACW
       430        440        450        460        470        480
SRLGGGRLPV ACASLPTQED GYCVLIGPAA ERISEEVGLL QLLGDPPPQQ VTQTDDPDVG
       490        500        510        520        530        540
LAYVFGPDAN SGQVARYHFP SLFFRDFSLL FHIRPATEGP GVLFAITDSA QAMVLLGVKL
       550        560        570        580        590        600
SGVQDGHQDI SLLYTEPGAG QTHTAASFRL PAFVGQWTHL ALSVAGGFVA LYVDCEEFQR
       610        620        630        640        650        660
MPLARSSRGL ELEPGAGLFV AQAGGADPDK FQGVIAELKV RRDPQVSPMH CLDEEGDDSD
       670        680        690        700        710        720
GASGDSGSGL GDARELLREE TGAALKPRLP APPPVTTPPL AGGSSTEDSR SEEVEEQTTV
       730        740        750        760        770        780
ASLGAQTLPG SDSVSTWDGS VRTPGGRVKE GGLKGQKGEP GVPGPPGRAG PPGSPCLPGP
       790        800        810        820        830        840
PGLPCPVSPL GPAGPALQTV PGPQGPPGPP GRDGTPGRDG EPGDPGEDGK PGDTGPQGFP
       850        860        870        880        890        900
GTPGDVGPKG DKGDPGVGER GPPGPQGPPG PPGPSFRHDK LTFIDMEGSG FGGDLEALRG
       910        920        930        940        950        960
PRGFPGPPGP PGVPGLPGEP GRFGVNSSDV PGPAGLPGVP GREGPPGFPG LPGPPGPPGR
       970        980        990       1000       1010       1020
EGPPGRTGQK GSLGEAGAPG HKGSKGAPGP AGARGESGLA GAPGPAGPPG PPGPPGPPGP
      1030       1040       1050       1060       1070       1080
GLPAGFDDME GSGGPFWSTA RSADGPQGPP GLPGLKGDPG VPGLPGAKGE VGADGVPGFP
      1090       1100       1110       1120       1130       1140
GLPGREGIAG PQGPKGDRGS RGEKGDPGKD GVGQPGLPGP PGPPGPVVYV SEQDGSVLSV
      1150       1160       1170       1180       1190       1200
PGPEGRPGFA GFPGPAGPKG NLGSKGERGS PGPKGEKGEP GSIFSPDGGA LGPAQKGAKG
      1210       1220       1230       1240       1250       1260
EPGFRGPPGP YGRPGYKGEI GFPGRPGRPG MNGLKGEKGE PGDASLGFGM RGMPGPPGPP
      1270       1280       1290       1300       1310       1320
GPPGPPGTPV YDSNVFAESS RPGPPGLPGN QGPPGPKGAK GEVGPPGPPG QFPFDFLQLE
      1330       1340       1350       1360       1370       1380
AEMKGEKGDR GDAGQKGERG EPGGGGFFGS SLPGPPGPPG PPGPRGYPGI PGPKGESIRG
      1390       1400       1410       1420       1430       1440
QPGPPGPQGP PGIGYEGRQG PPGPPGPPGP PSFPGPHRQT ISVPGPPGPP GPPGPPGTMG
      1450       1460       1470       1480       1490       1500
ASSGVRLWAT RQAMLGQVHE VPEGWLIFVA EQEELYVRVQ NGFRKVQLEA RTPLPRGTDN
      1510       1520       1530       1540       1550       1560
EVAALQPPVV QLHDSNPYPR REHPHPTARP WRADDILASP PRLPEPQPYP GAPHHSSYVH
      1570       1580       1590       1600       1610       1620
LRPARPTSPP AHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF
      1630       1640       1650       1660       1670       1680
LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL
      1690       1700       1710       1720       1730       1740
RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY
      1750
IVLCIENSFM TASK         10         20         30         40         50         60
MAPYPCGCHI LLLLFCCLAA ARANLLNLNW LWFNNEDTSH AATTIPEPQG PLPVQPTADT
        70         80         90        100        110        120
TTHVTPRNGS TEPATAPGSP EPPSELLEDG QDTPTSAESP DAPEENIAGV GAEILNVAKG
       130        140        150        160        170        180
IRSFVQLWND TVPTESLARA ETLVLETPVG PLALAGPSST PQENGTTLWP SRGIPSSPGA
       190        200        210        220        230        240
HTTEAGTLPA PTPSPPSLGR PWAPLTGPSV PPPSSGRASL SSLLGGAPPW GSLQDPDSQG
       250        260        270        280        290        300
LSPAAAAPSQ QLQRPDVRLR TPLLHPLVMG SLGKHAAPSA FSSGLPGALS QVAVTTLTRD
       310        320        330        340        350        360
SGAWVSHVAN SVGPGLANNS ALLGADPEAP AGRCLPLPPS LPVCGHLGIS RFWLPNHLHH
       370        380        390        400        410        420
ESGEQVRAGA RAWGGLLQTH CHPFLAWFFC LLLVPPCGSV PPPAPPPCCQ FCEALQDACW
       430        440        450        460        470        480
SRLGGGRLPV ACASLPTQED GYCVLIGPAA ERISEEVGLL QLLGDPPPQQ VTQTDDPDVG
       490        500        510        520        530        540
LAYVFGPDAN SGQVARYHFP SLFFRDFSLL FHIRPATEGP GVLFAITDSA QAMVLLGVKL
       550        560        570        580        590        600
SGVQDGHQDI SLLYTEPGAG QTHTAASFRL PAFVGQWTHL ALSVAGGFVA LYVDCEEFQR
       610        620        630        640        650        660
MPLARSSRGL ELEPGAGLFV AQAGGADPDK FQGVIAELKV RRDPQVSPMH CLDEEGDDSD
       670        680        690        700        710        720
GASGDSGSGL GDARELLREE TGAALKPRLP APPPVTTPPL AGGSSTEDSR SEEVEEQTTV
       730        740        750        760        770        780
ASLGAQTLPG SDSVSTWDGS VRTPGGRVKE GGLKGQKGEP GVPGPPGRAG PPGSPCLPGP
       790        800        810        820        830        840
PGLPCPVSPL GPAGPALQTV PGPQGPPGPP GRDGTPGRDG EPGDPGEDGK PGDTGPQGFP
       850        860        870        880        890        900
GTPGDVGPKG DKGDPGVGER GPPGPQGPPG PPGPSFRHDK LTFIDMEGSG FGGDLEALRG
       910        920        930        940        950        960
PRGFPGPPGP PGVPGLPGEP GRFGVNSSDV PGPAGLPGVP GREGPPGFPG LPGPPGPPGR
       970        980        990       1000       1010       1020
EGPPGRTGQK GSLGEAGAPG HKGSKGAPGP AGARGESGLA GAPGPAGPPG PPGPPGPPGP
      1030       1040       1050       1060       1070       1080
GLPAGFDDME GSGGPFWSTA RSADGPQGPP GLPGLKGDPG VPGLPGAKGE VGADGVPGFP
      1090       1100       1110       1120       1130       1140
GLPGREGIAG PQGPKGDRGS RGEKGDPGKD GVGQPGLPGP PGPPGPVVYV SEQDGSVLSV
      1150       1160       1170       1180       1190       1200
PGPEGRPGFA GFPGPAGPKG NLGSKGERGS PGPKGEKGEP GSIFSPDGGA LGPAQKGAKG
      1210       1220       1230       1240       1250       1260
EPGFRGPPGP YGRPGYKGEI GFPGRPGRPG MNGLKGEKGE PGDASLGFGM RGMPGPPGPP
      1270       1280       1290       1300       1310       1320
GPPGPPGTPV YDSNVFAESS RPGPPGLPGN QGPPGPKGAK GEVGPPGPPG QFPFDFLQLE
      1330       1340       1350       1360       1370       1380
AEMKGEKGDR GDAGQKGERG EPGGGGFFGS SLPGPPGPPG PPGPRGYPGI PGPKGESIRG
      1390       1400       1410       1420       1430       1440
QPGPPGPQGP PGIGYEGRQG PPGPPGPPGP PSFPGPHRQT ISVPGPPGPP GPPGPPGTMG
      1450       1460       1470       1480       1490       1500
ASSGVRLWAT RQAMLGQVHE VPEGWLIFVA EQEELYVRVQ NGFRKVQLEA RTPLPRGTDN
      1510       1520       1530       1540       1550       1560
EVAALQPPVV QLHDSNPYPR REHPHPTARP WRADDILASP PRLPEPQPYP GAPHHSSYVH
      1570       1580       1590       1600       1610       1620
LRPARPTSPP AHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF
      1630       1640       1650       1660       1670       1680
LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL
      1690       1700       1710       1720       1730       1740
RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY
      1750
IVLCIENSFM TASK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

13 N-termini - 9 C-termini - 13 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P39060-24-unknown	NLLNLN...	24	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P39060-679-unknown	EETGAA...	679	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19091
P39060-679-unknown	EETGAA...	679	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17632
P39060-679-unknown	EETGAA...	679	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148956
P39060-725-unknown	AQTLPG...	725	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178413
P39060-725-	AQTLPG...	725		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P39060-1512-unknown	LHDSNP...	1512	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC24764
P39060-1512-unknown	LHDSNP...	1512	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157363
P39060-1531-unknown	WRADDI...	1531	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26435
P39060-1531-unknown	WRADDI...	1531	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21406
P39060-1531-unknown	WRADDI...	1531	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157431
P39060-1533-unknown	ADDILA...	1533		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P39060-1533-unknown	ADDILA...	1533	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180245
P39060-1536-unknown	ILASPP...	1536	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC24767
P39060-1536-unknown	ILASPP...	1536	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157448
P39060-1549-unknown	YPGAPH...	1549	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26438
P39060-1549-unknown	YPGAPH...	1549	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157479
P39060-1556-unknown	SSYVHL...	1556	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21409
P39060-1556-unknown	SSYVHL...	1556	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157489
P39060-1558-unknown	YVHLRP...	1558	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21802
P39060-1558-unknown	YVHLRP...	1558	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23929
P39060-1558-unknown	YVHLRP...	1558	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21412
P39060-1558-unknown	YVHLRP...	1558	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC24770
P39060-1558-unknown	YVHLRP...	1558	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157492
P39060-1572-unknown	HSHRDF...	1572	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P39060-1572-unknown	HSHRDF...	1572	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116500
P39060-1573-unknown	SHRDFQ...	1573	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23932
P39060-1573-unknown	SHRDFQ...	1573	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157512

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RELLRE	678	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19091
...RELLRE	678	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17632
...RELLRE	678	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132337
...PPVVQL	1511	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24764
...PPVVQL	1511	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140862
...PTARPW	1530	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26435
...PTARPW	1530	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21406
...PTARPW	1530	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140929
...WRADDI	1535	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24767
...WRADDI	1535	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140946
...PEPQPY	1548	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26438
...PEPQPY	1548	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140977
...GAPHHS	1555	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21409
...GAPHHS	1555	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140987
...PHHSSY	1557	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21802
...PHHSSY	1557	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23929
...PHHSSY	1557	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21412
...PHHSSY	1557	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24770
...PHHSSY	1557	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140990
...SPPAHS	1572	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23932
...SPPAHS	1572	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141011
...MTASK	1754	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MTASK	1754	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66997

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	678	LLRE.\|.EETG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	678	LLRE.\|.EETG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MMP7_HUMAN	1511	VVQL.\|.LHDS	inferred from experiment	unknown	MEROPS	Pihlajaniemi T	Heljasvaara R et al.:Generation of biologically acti... (M10.013)	15950618,
MMP9_HUMAN	1530	ARPW.\|.WRAD	inferred from experiment	unknown	MEROPS	Pihlajaniemi T	Heljasvaara R et al.:Generation of biologically acti... (M10.013)	15950618,
MMP13_HUMAN	1530	ARPW.\|.WRAD	inferred from experiment	unknown	MEROPS	Pihlajaniemi T	Heljasvaara R et al.:Generation of biologically acti... (M10.013)	15950618,
MMP7_HUMAN	1535	ADDI.\|.ILAS	inferred from experiment	unknown	MEROPS	Pihlajaniemi T	Heljasvaara R et al.:Generation of biologically acti... (M10.013)	15950618,
MMP9_HUMAN	1548	PQPY.\|.YPGA	inferred from experiment	unknown	MEROPS	Pihlajaniemi T	Heljasvaara R et al.:Generation of biologically acti... (M10.013)	15950618,
MMP13_HUMAN	1555	PHHS.\|.SSYV	inferred from experiment	unknown	MEROPS	Pihlajaniemi T	Heljasvaara R et al.:Generation of biologically acti... (M10.013)	15950618,
MMP20_HUMAN	1557	HSSY.\|.YVHL	inferred from experiment	unknown	MEROPS	Pihlajaniemi T	Heljasvaara R et al.:Generation of biologically acti... (M10.013)	15950618,
MMP3_HUMAN	1557	HSSY.\|.YVHL	inferred from experiment	unknown	MEROPS	Pihlajaniemi T	Heljasvaara R et al.:Generation of biologically acti... (M10.013)	15950618,
MMP13_HUMAN	1557	HSSY.\|.YVHL	inferred from experiment	unknown	MEROPS	Pihlajaniemi T	Heljasvaara R et al.:Generation of biologically acti... (M10.013)	15950618,
MMP7_HUMAN	1557	HSSY.\|.YVHL	inferred from experiment	unknown	MEROPS	Pihlajaniemi T	Heljasvaara R et al.:Generation of biologically acti... (M10.013)	15950618,
MMP3_HUMAN	1572	PAHS.\|.SHRD	inferred from experiment	unknown	MEROPS	Pihlajaniemi T	Heljasvaara R et al.:Generation of biologically acti... (M10.013)	15950618,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)