P13010: X-ray repair cross-complementing protein 5

General Information

Protein names	- X-ray repair cross-complementing protein 5 - 3.6.4.- - 86 kDa subunit of Ku antigen - ATP-dependent DNA helicase 2 subunit 2 - ATP-dependent DNA helicase II 80 kDa subunit - CTC box-binding factor 85 kDa subunit - CTC85 - CTCBF - DNA repair protein XRCC5 - Ku80 - Ku86 - Lupus Ku autoantigen protein p86 - Nuclear factor IV - Thyroid-lupus autoantigen - TLAA - X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Gene names	XRCC5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P13010

20 N-termini

10 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVRSGNKAAV VLCMDVGFTM SNSIPGIESP FEQAKKVITM FVQRQVFAEN KDEIALVLFG
        70         80         90        100        110        120
TDGTDNPLSG GDQYQNITVH RHLMLPDFDL LEDIESKIQP GSQQADFLDA LIVSMDVIQH
       130        140        150        160        170        180
ETIGKKFEKR HIEIFTDLSS RFSKSQLDII IHSLKKCDIS LQFFLPFSLG KEDGSGDRGD
       190        200        210        220        230        240
GPFRLGGHGP SFPLKGITEQ QKEGLEIVKM VMISLEGEDG LDEIYSFSES LRKLCVFKKI
       250        260        270        280        290        300
ERHSIHWPCR LTIGSNLSIR IAAYKSILQE RVKKTWTVVD AKTLKKEDIQ KETVYCLNDD
       310        320        330        340        350        360
DETEVLKEDI IQGFRYGSDI VPFSKVDEEQ MKYKSEGKCF SVLGFCKSSQ VQRRFFMGNQ
       370        380        390        400        410        420
VLKVFAARDD EAAAVALSSL IHALDDLDMV AIVRYAYDKR ANPQVGVAFP HIKHNYECLV
       430        440        450        460        470        480
YVQLPFMEDL RQYMFSSLKN SKKYAPTEAQ LNAVDALIDS MSLAKKDEKT DTLEDLFPTT
       490        500        510        520        530        540
KIPNPRFQRL FQCLLHRALH PREPLPPIQQ HIWNMLNPPA EVTTKSQIPL SKIKTLFPLI
       550        560        570        580        590        600
EAKKKDQVTA QEIFQDNHED GPTAKKLKTE QGGAHFSVSS LAEGSVTSVG SVNPAENFRV
       610        620        630        640        650        660
LVKQKKASFE EASNQLINHI EQFLDTNETP YFMKSIDCIR AFREEAIKFS EEQRFNNFLK
       670        680        690        700        710        720
ALQEKVEIKQ LNHFWEIVVQ DGITLITKEE ASGSSVTAEE AKKFLAPKDK PSGDTAAVFE
       730
EGGDVDDLLD MI

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

20 N-termini - 10 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P13010-2-unknown	VRSGNK...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P13010-14-unknown	MDVGFT...	14	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000401318
P13010-23-	SIPGIE...	23		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P13010-23-	SIPGIE...	23		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P13010-70-unknown	GGDQYQ...	70	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7304
P13010-82-	HLMLPD...	82		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P13010-84-	MLPDFD...	84		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P13010-187-unknown	GHGPSF...	187	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5582
P13010-303-unknown	TEVLKE...	303	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17324
P13010-407-unknown	VAFPHI...	407	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3639
P13010-407-unknown	VAFPHI...	407	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7305
P13010-407-unknown	VAFPHI...	407	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5583
P13010-453-	AVDALI...	453		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P13010-453-	AVDALI...	453		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P13010-453-	AVDALI...	453		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P13010-453-	AVDALI...	453		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P13010-456-unknown	ALIDSM...	456	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18714
P13010-456-unknown	ALIDSM...	456		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P13010-456-	ALIDSM...	456		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P13010-456-	ALIDSM...	456		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P13010-456-	ALIDSM...	456		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P13010-550-unknown	AQEIFQ...	550	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7306
P13010-550-unknown	AQEIFQ...	550	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5584
P13010-557-	NHEDGP...	557		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P13010-557-unknown	NHEDGP...	557		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P13010-580-	SLAEGS...	580		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P13010-580-	SLAEGS...	580		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P13010-585-	SVTSVG...	585		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P13010-585-	SVTSVG...	585		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P13010-588-	SVGSVN...	588		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P13010-588-	SVGSVN...	588		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P13010-588-	SVGSVN...	588		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P13010-588-unknown	SVGSVN...	588	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3640
P13010-591-unknown	SVNPAE...	591	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7307
P13010-591-unknown	SVNPAE...	591	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5585

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DNPLSG	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7304
...SRFSKS	144	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401318
...PFRLGG	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5582
...NDDDET	302	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17324
...NPQVGV	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3639
...NPQVGV	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7305
...NPQVGV	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5583
...LNAVDA	455	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18714
...KDQVTA	549	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7306
...KDQVTA	549	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5584
...EGSVTS	587	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3640
...VTSVGS	590	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7307
...VTSVGS	590	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5585
...LLDMI	732	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	69	PLSG.\|.GGDQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	186	RLGG.\|.GHGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	302	DDET.\|.TEVL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	406	QVGV.\|.VAFP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	406	QVGV.\|.VAFP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	406	QVGV.\|.VAFP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	455	AVDA.\|.ALID	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	549	QVTA.\|.AQEI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	549	QVTA.\|.AQEI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	587	SVTS.\|.SVGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	590	SVGS.\|.SVNP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	590	SVGS.\|.SVNP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)