P52907: F-actin-capping protein subunit alpha-1

General Information

Protein names	- F-actin-capping protein subunit alpha-1 - CapZ alpha-1
Gene names	CAPZA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52907

5 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADFDDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNMD
        70         80         90        100        110        120
QFTPVKIEGY EDQVLITEHG DLGNSRFLDP RNKISFKFDH LRKEASDPQP EEADGGLKSW
       130        140        150        160        170        180
RESCDSALRA YVKDHYSNGF CTVYAKTIDG QQTIIACIES HQFQPKNFWN GRWRSEWKFT
       190        200        210        220        230        240
ITPPTAQVVG VLKIQVHYYE DGNVQLVSHK DVQDSLTVSN EAQTAKEFIK IIENAENEYQ
       250        260        270        280
TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P52907-2-unknown	MADFDD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52907-2-Acetylation	ADFDDR...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52907-2-Acetylation	ADFDDR...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P52907-36-unknown	VRLLLN...	36		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2576
P52907-107-unknown	DPQPEE...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17718
P52907-107-unknown	DPQPEE...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19191
P52907-115-unknown	GGLKSW...	115		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2577

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EVFNDV	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2576
...RKEASD	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17718
...RKEASD	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19191
...PEEADG	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2577
...EMQNA	286	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	35	FNDV.\|.VRLL	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
MEP1A_HUMAN	106	EASD.\|.DPQP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	106	EASD.\|.DPQP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP6_HUMAN	114	EADG.\|.GGLK	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)