Q13435: Splicing factor 3B subunit 2

General Information

Protein names	- Splicing factor 3B subunit 2 - Pre-mRNA-splicing factor SF3b 145 kDa subunit - SF3b145 - Spliceosome-associated protein 145 - SAP 145
Gene names	SF3B2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13435

35 N-termini

21 C-termini

18 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATEHPEPPK AELQLPPPPP PGHYGAWAAQ ELQAKLAEIG APIQGNREEL VERLQSYTRQ
        70         80         90        100        110        120
TGIVLNRPVL RGEDGDKAAP PPMSAQLPGI PMPPPPLGLP PLQPPPPPPP PPPGLGLGFP
       130        140        150        160        170        180
MAHPPNLGPP PPLRVGEPVA LSEEERLKLA QQQAALLMQQ EERAKQQGDH SLKEHELLEQ
       190        200        210        220        230        240
QKRAAVLLEQ ERQQEIAKMG TPVPRPPQDM GQIGVRTPLG PRVAAPVGPV GPTPTVLPMG
       250        260        270        280        290        300
APVPRPRGPP PPPGDENREM DDPSVGPKIP QALEKILQLK ESRQEEMNSQ QEEEEMETDA
       310        320        330        340        350        360
RSSLGQSASE TEEDTVSVSK KEKNRKRRNR KKKKKPQRVR GVSSESSGDR EKDSTRSRGS
       370        380        390        400        410        420
DSPAADVEIE YVTEEPEIYE PNFIFFKRIF EAFKLTDDVK KEKEKEPEKL DKLENSAAPK
       430        440        450        460        470        480
KKGFEEEHKD SDDDSSDDEQ EKKPEAPKLS KKKLRRMNRF TVAELKQLVA RPDVVEMHDV
       490        500        510        520        530        540
TAQDPKLLVH LKATRNSVPV PRHWCFKRKY LQGKRGIEKP PFELPDFIKR TGIQEMREAL
       550        560        570        580        590        600
QEKEEQKTMK SKMREKVRPK MGKIDIDYQK LHDAFFKWQT KPKLTIHGDL YYEGKEFETR
       610        620        630        640        650        660
LKEKKPGDLS DELRISLGMP VGPNAHKVPP PWLIAMQRYG PPPSYPNLKI PGLNSPIPES
       670        680        690        700        710        720
CSFGYHAGGW GKPPVDETGK PLYGDVFGTN AAEFQTKTEE EEIDRTPWGE LEPSDEESSE
       730        740        750        760        770        780
EEEEEESDED KPDETGFITP ADSGLITPGG FSSVPAGMET PELIELRKKK IEEAMDGSET
       790        800        810        820        830        840
PQLFTVLPEK RTATVGGAMM GSTHIYDMST VMSRKGPAPE LQGVEVALAP EELELDPMAM
       850        860        870        880        890
TQKYEEHVRE QQAQVEKEDF SDMVAEHAAK QKQKKRKAQP QDSRGGSKKY KEFKF

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

35 N-termini - 21 C-termini - 18 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13435-1-unknown	MATEHP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13435-6-unknown	PEPPKA...	6	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431520
Q13435-83-unknown	MSAQLP...	83	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000435765
Q13435-122-unknown	AHPPNL...	122	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6340
Q13435-155-	ALLMQQ...	155		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13435-155-	ALLMQQ...	155		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13435-171-	SLKEHE...	171		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13435-261-unknown	DDPSVG...	261	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17901
Q13435-261-unknown	DDPSVG...	261	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19440
Q13435-269-	IPQALE...	269		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13435-288-unknown	NSQQEE...	288	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14431
Q13435-302-	SSLGQS...	302		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13435-315-	TVSVSK...	315		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13435-315-	TVSVSK...	315		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13435-341-	GVSSES...	341		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13435-375-unknown	EPEIYE...	375	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17902
Q13435-375-unknown	EPEIYE...	375	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19441
Q13435-474-	VVEMHD...	474		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13435-538-	EALQEK...	538		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13435-541-unknown	QEKEEQ...	541	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14432
Q13435-547-unknown	KTMKSK...	547	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14433
Q13435-590-unknown	LYYEGK...	590	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12079
Q13435-619-unknown	MPVGPN...	619	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6341
Q13435-667-unknown	AGGWGK...	667	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3989
Q13435-668-unknown	GGWGKP...	668	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3990
Q13435-669-unknown	GWGKPP...	669	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3991
Q13435-672-unknown	KPPVDE...	672	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6342
Q13435-713-unknown	PSDEES...	713		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13435-736-	GFITPA...	736		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13435-736-	GFITPA...	736		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13435-736-	GFITPA...	736		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13435-743-unknown	SGLITP...	743	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12080
Q13435-754-unknown	VPAGME...	754		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13435-760-unknown	TPELIE...	760		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13435-777-	GSETPQ...	777		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13435-777-	GSETPQ...	777		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13435-777-	GSETPQ...	777		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13435-777-	GSETPQ...	777		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q13435-777-	GSETPQ...	777		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13435-777-	GSETPQ...	777		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13435-777-	GSETPQ...	777		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13435-777-	GSETPQ...	777		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q13435-777-	GSETPQ...	777		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13435-783-	LFTVLP...	783		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13435-783-	LFTVLP...	783		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13435-797-	GAMMGS...	797		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13435-797-	GAMMGS...	797		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13435-797-	GAMMGS...	797		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13435-802-	STHIYD...	802		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13435-827-	ALAPEE...	827		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13435-827-	ALAPEE...	827		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q13435-832-unknown	ELELDP...	832	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12081
Q13435-859-unknown	DFSDMV...	859	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12082

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LGFPMA	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6340
...MQQEER	162	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435765
...ENREMD	260	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17901
...ENREMD	260	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19440
...PQALEK	274	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435495
...RQEEMN	287	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14431
...EKDSTR	355	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431908
...EYVTEE	374	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17902
...EYVTEE	374	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19441
...IFEAFK	393	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431520
...MREALQ	540	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14432
...EKEEQK	546	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14433
...TIHGDL	589	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12079
...RISLGM	618	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6341
...SFGYHA	666	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3989
...FGYHAG	667	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3990
...GYHAGG	668	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3991
...AGGWGK	671	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6342
...ITPADS	742	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12080
...ALAPEE	831	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12081
...QVEKED	858	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12082
...YKEFKF	894	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8234
...KEFKF	895	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	121	FPMA.\|.AHPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	260	REMD.\|.DDPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	260	REMD.\|.DDPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	287	EEMN.\|.NSQQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	374	VTEE.\|.EPEI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	374	VTEE.\|.EPEI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	540	EALQ.\|.QEKE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	546	EEQK.\|.KTMK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	589	HGDL.\|.LYYE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	618	SLGM.\|.MPVG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	666	GYHA.\|.AGGW	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	667	YHAG.\|.GGWG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	668	HAGG.\|.GWGK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	671	GWGK.\|.KPPV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	742	PADS.\|.SGLI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	831	APEE.\|.ELEL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	858	EKED.\|.DFSD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CBPA4_HUMAN	894	EFKF.\|.F	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)