P29401: Transketolase

General Information

Protein names	- Transketolase - TK - 2.2.1.1 {ECO:0000269\|PubMed:27259054}
Gene names	TKT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P29401

17 N-termini

11 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MESYHKPDQQ KLQALKDTAN RLRISSIQAT TAAGSGHPTS CCSAAEIMAV LFFHTMRYKS
        70         80         90        100        110        120
QDPRNPHNDR FVLSKGHAAP ILYAVWAEAG FLAEAELLNL RKISSDLDGH PVPKQAFTDV
       130        140        150        160        170        180
ATGSLGQGLG AACGMAYTGK YFDKASYRVY CLLGDGELSE GSVWEAMAFA SIYKLDNLVA
       190        200        210        220        230        240
ILDINRLGQS DPAPLQHQMD IYQKRCEAFG WHAIIVDGHS VEELCKAFGQ AKHQPTAIIA
       250        260        270        280        290        300
KTFKGRGITG VEDKESWHGK PLPKNMAEQI IQEIYSQIQS KKKILATPPQ EDAPSVDIAN
       310        320        330        340        350        360
IRMPSLPSYK VGDKIATRKA YGQALAKLGH ASDRIIALDG DTKNSTFSEI FKKEHPDRFI
       370        380        390        400        410        420
ECYIAEQNMV SIAVGCATRN RTVPFCSTFA AFFTRAFDQI RMAAISESNI NLCGSHCGVS
       430        440        450        460        470        480
IGEDGPSQMA LEDLAMFRSV PTSTVFYPSD GVATEKAVEL AANTKGICFI RTSRPENAII
       490        500        510        520        530        540
YNNNEDFQVG QAKVVLKSKD DQVTVIGAGV TLHEALAAAE LLKKEKINIR VLDPFTIKPL
       550        560        570        580        590        600
DRKLILDSAR ATKGRILTVE DHYYEGGIGE AVSSAVVGEP GITVTHLAVN RVPRSGKPAE
       610        620
LLKMFGIDRD AIAQAVRGLI TKA

Isoforms

- Isoform 2 of Transketolase

Sequence View

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Protein Neighborhood

Domains & Features

17 N-termini - 11 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P29401-1-unknown	MESYHK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92227
P29401-1-Acetylation	MESYHK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P29401-1-Acetylation	MESYHK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P29401-1-Acetylation	MESYHK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P29401-1-Acetylation	MESYHK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107924
P29401-29-unknown	ATTAAG...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5757
P29401-29-unknown	ATTAAG...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7401
P29401-29-unknown	ATTAAG...	29		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137473
P29401-31-unknown	TAAGSG...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5759
P29401-31-unknown	TAAGSG...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137629
P29401-32-unknown	AAGSGH...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7403
P29401-32-unknown	AAGSGH...	32		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137752
P29401-105-unknown	SDLDGH...	105		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5761
P29401-105-unknown	SDLDGH...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142647
P29401-197-unknown	HQMDIY...	197		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5763
P29401-197-unknown	HQMDIY...	197		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146719
P29401-213-unknown	AIIVDG...	213		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5765
P29401-213-unknown	AIIVDG...	213		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147388
P29401-214-unknown	IIVDGH...	214		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3752
P29401-214-unknown	IIVDGH...	214		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147446
P29401-414-unknown	GSHCGV...	414		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166861
P29401-414-	GSHCGV...	414			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P29401-414-	GSHCGV...	414			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P29401-439-unknown	SVPTST...	439		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166863
P29401-439-	SVPTST...	439			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P29401-439-	SVPTST...	439			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P29401-439-	SVPTST...	439			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P29401-450-unknown	DGVATE...	450		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18998
P29401-450-unknown	DGVATE...	450		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17543
P29401-450-unknown	DGVATE...	450		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152881
P29401-457-unknown	AVELAA...	457		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166865
P29401-457-	AVELAA...	457			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P29401-457-	AVELAA...	457			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P29401-457-	AVELAA...	457			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P29401-514-unknown	EALAAA...	514		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19000
P29401-514-unknown	EALAAA...	514		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153637

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...ISSIQA	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5757
...ISSIQA	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7401
...ISSIQA	28	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120439
...SIQATT	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5759
...SIQATT	30	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120624
...IQATTA	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7403
...IQATTA	31	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120751
...LRKISS	104	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5761
...LRKISS	104	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt125845
...PAPLQH	196	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5763
...PAPLQH	196	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt130031
...AFGWHA	212	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5765
...AFGWHA	212	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt130735
...FGWHAI	213	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3752
...FGWHAI	213	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt130796
...VFYPSD	449	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18998
...VFYPSD	449	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17543
...VFYPSD	449	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136306
...GVTLHE	513	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19000
...GVTLHE	513	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137061
...LITKA	623		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LITKA	623	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LITKA	623	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt87845
...LITKA	623		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LITKA	623		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	28	SIQA.\|.ATTA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	28	SIQA.\|.ATTA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	30	QATT.\|.TAAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	31	ATTA.\|.AAGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	104	KISS.\|.SDLD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	196	PLQH.\|.HQMD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	212	GWHA.\|.AIIV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	213	WHAI.\|.IIVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	449	YPSD.\|.DGVA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	449	YPSD.\|.DGVA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	513	TLHE.\|.EALA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)