Q15459: Splicing factor 3A subunit 1

General Information

Protein names	- Splicing factor 3A subunit 1 - SF3a120 {ECO:0000303\|PubMed:11533230, ECO:0000303\|PubMed:21349847, ECO:0000303\|PubMed:7489498} - Spliceosome-associated protein 114 - SAP 114
Gene names	SF3A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15459

27 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPAGPVQAVP PPPPVPTEPK QPTEEEASSK EDSAPSKPVV GIIYPPPEVR NIVDKTASFV
        70         80         90        100        110        120
ARNGPEFEAR IRQNEINNPK FNFLNPNDPY HAYYRHKVSE FKEGKAQEPS AAIPKVMQQQ
       130        140        150        160        170        180
QQTTQQQLPQ KVQAQVIQET IVPKEPPPEF EFIADPPSIS AFDLDVVKLT AQFVARNGRQ
       190        200        210        220        230        240
FLTQLMQKEQ RNYQFDFLRP QHSLFNYFTK LVEQYTKILI PPKGLFSKLK KEAENPREVL
       250        260        270        280        290        300
DQVCYRVEWA KFQERERKKE EEEKEKERVA YAQIDWHDFV VVETVDFQPN EQGNFPPPTT
       310        320        330        340        350        360
PEELGARILI QERYEKFGES EEVEMEVESD EEDDKQEKAE EPPSQLDQDT QVQDMDEGSD
       370        380        390        400        410        420
DEEEGQKVPP PPETPMPPPL PPTPDQVIVR KDYDPKASKP LPPAPAPDEY LVSPITGEKI
       430        440        450        460        470        480
PASKMQEHMR IGLLDPRWLE QRDRSIREKQ SDDEVYAPGL DIESSLKQLA ERRTDIFGVE
       490        500        510        520        530        540
ETAIGKKIGE EEIQKPEEKV TWDGHSGSMA RTQQAAQANI TLQEQIEAIH KAKGLVPEDD
       550        560        570        580        590        600
TKEKIGPSKP NEIPQQPPPP SSATNIPSSA PPITSVPRPP TMPPPVRTTV VSAVPVMPRP
       610        620        630        640        650        660
PMASVVRLPP GSVIAPMPPI IHAPRINVVP MPPSAPPIMA PRPPPMIVPT AFVPAPPVAP
       670        680        690        700        710        720
VPAPAPMPPV HPPPPMEDEP TSKKLKTEDS LMPEEEFLRR NKGPVSIKVQ VPNMQDKTEW
       730        740        750        760        770        780
KLNGQVLVFT LPLTDQVSVI KVKIHEATGM PAGKQKLQYE GIFIKDSNSL AYYNMANGAV
       790
IHLALKERGG RKK

Isoforms

- Isoform 2 of Splicing factor 3A subunit 1

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

27 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15459-1-unknown	MPAGPV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15459-1-unknown	MPAGPV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89388
Q15459-2-unmodified	PAGPVQ...	2		other		CNRS/ISV	Large_scale_NTA_Human
Q15459-2-unknown	PAGPVQ...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163329
Q15459-2-unknown	PAGPVQ...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15459-3-unknown	AGPVQA...	3		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15459-3-unknown	AGPVQA...	3	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162089
Q15459-3-	AGPVQA...	3		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15459-3-	AGPVQA...	3		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15459-3-	AGPVQA...	3		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q15459-3-	AGPVQA...	3		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15459-3-	AGPVQA...	3		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15459-3-	AGPVQA...	3		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15459-4-unknown	GPVQAV...	4		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15459-4-unknown	GPVQAV...	4	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162095
Q15459-4-	GPVQAV...	4		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15459-6-unknown	VQAVPP...	6		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15459-6-unknown	VQAVPP...	6	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162097
Q15459-6-	VQAVPP...	6		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15459-6-	VQAVPP...	6		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15459-6-	VQAVPP...	6		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q15459-6-	VQAVPP...	6		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15459-6-	VQAVPP...	6		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15459-6-	VQAVPP...	6		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q15459-8-unknown	AVPPPP...	8		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15459-8-unknown	AVPPPP...	8	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162091
Q15459-8-	AVPPPP...	8		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15459-8-	AVPPPP...	8		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q15459-8-	AVPPPP...	8		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15459-33-unknown	SAPSKP...	33	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165060
Q15459-33-	SAPSKP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15459-33-	SAPSKP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15459-33-	SAPSKP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q15459-224-unknown	GLFSKL...	224	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q15459-224-unknown	GLFSKL...	224	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198274
Q15459-305-unknown	GARILI...	305	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000400862
Q15459-305-unknown	GARILI...	305	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130815
Q15459-397-	ASKPLP...	397		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15459-397-unknown	ASKPLP...	397	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169574
Q15459-457-unknown	APGLDI...	457	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17983
Q15459-457-unknown	APGLDI...	457	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19580
Q15459-457-unknown	APGLDI...	457	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151870
Q15459-476-unknown	IFGVEE...	476	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17985
Q15459-476-unknown	IFGVEE...	476	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152169
Q15459-504-unknown	GHSGSM...	504		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15459-504-unknown	GHSGSM...	504	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162093
Q15459-504-	GHSGSM...	504		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15459-504-	GHSGSM...	504		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15459-504-	GHSGSM...	504		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q15459-504-	GHSGSM...	504		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15459-504-	GHSGSM...	504		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15459-524-unknown	EQIEAI...	524	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6478
Q15459-524-unknown	EQIEAI...	524	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152895
Q15459-532-	AKGLVP...	532		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15459-532-unknown	AKGLVP...	532	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169576
Q15459-678-unknown	DEPTSK...	678	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17987
Q15459-678-unknown	DEPTSK...	678	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19582
Q15459-678-unknown	DEPTSK...	678	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154792
Q15459-690-	SLMPEE...	690		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15459-690-unknown	SLMPEE...	690	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DDEVYA	456	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17983
...DDEVYA	456	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19580
...DDEVYA	456	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135275
...ERRTDI	475	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17985
...ERRTDI	475	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135579
...NITLQE	523	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6478
...NITLQE	523	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136320
...SVVRLP	608	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400862
...SVVRLP	608	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110503
...PPPMED	677	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17987
...PPPMED	677	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19582
...PPPMED	677	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138218
...GGRKK	793	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GGRKK	793	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85006

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	456	EVYA.\|.APGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	456	EVYA.\|.APGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	475	RTDI.\|.IFGV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	523	TLQE.\|.EQIE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	677	PMED.\|.DEPT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	677	PMED.\|.DEPT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)