P53999: Activated RNA polymerase II transcriptional coactivator p15

General Information

Protein names	- Activated RNA polymerase II transcriptional coactivator p15 - Positive cofactor 4 - PC4 - SUB1 homolog - p14
Gene names	SUB1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P53999

15 N-termini

9 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKSKELVSS SSSGSDSDSE VDKKLKRKKQ VAPEKPVKKQ KTGETSRALS SSKQSSSSRD
        70         80         90        100        110        120
DNMFQIGKMR YVSVRDFKGK VLIDIREYWM DPEGEMKPGR KGISLNPEQW SQLKEQISDI

DDAVRKL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

15 N-termini - 9 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P53999-2-unknown	PKSKEL...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53999-2-unknown	PKSKEL...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P53999-2-unknown	PKSKEL...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P53999-4-	SKELVS...	4		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P53999-4-	SKELVS...	4		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P53999-10-unknown	SSSSGS...	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19201
P53999-10-unknown	SSSSGS...	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3863
P53999-10-unknown	SSSSGS...	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6024
P53999-10-unknown	SSSSGS...	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7567
P53999-11-unknown	SSSGSD...	11	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19202
P53999-11-unknown	SSSGSD...	11	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17726
P53999-30-unknown	QVAPEK...	30		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P53999-30-	QVAPEK...	30		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P53999-31-	VAPEKP...	31		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P53999-39-unknown	KQKTGE...	39	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14205
P53999-48-	ALSSSK...	48		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P53999-48-	ALSSSK...	48		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P53999-48-unknown	ALSSSK...	48	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10098
P53999-50-	SSSKQS...	50		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P53999-51-	SSKQSS...	51		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P53999-55-unknown	SSSSRD...	55	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17727
P53999-60-unknown	DDNMFQ...	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19203
P53999-60-unknown	DDNMFQ...	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17728
P53999-105-unknown	LNPEQW...	105	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19204

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KELVSS	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19201
...KELVSS	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3863
...KELVSS	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6024
...KELVSS	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7567
...ELVSSS	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19202
...ELVSSS	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17726
...EKPVKK	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14205
...GETSRA	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10098
...SSSKQS	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17727
...SSSSRD	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19203
...SSSSRD	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17728
...DNMFQI	65	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423893
...RKGISL	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19204
...AVRKL	127	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	9	LVSS.\|.SSSS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	9	LVSS.\|.SSSS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	9	LVSS.\|.SSSS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	9	LVSS.\|.SSSS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	10	VSSS.\|.SSSG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	10	VSSS.\|.SSSG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	38	PVKK.\|.KQKT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	47	TSRA.\|.ALSS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1A_HUMAN	54	SKQS.\|.SSSS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	59	SSRD.\|.DDNM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	59	SSRD.\|.DDNM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	104	GISL.\|.LNPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)