P14866: Heterogeneous nuclear ribonucleoprotein L

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein L - hnRNP L
Gene names	HNRNPL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P14866

36 N-termini

8 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSRRLLPRAE KRRRRLEQRQ QPDEQRRRSG AMVKMAAAGG GGGGGRYYGG GSEGGRAPKR
        70         80         90        100        110        120
LKTDNAGDQH GGGGGGGGGA GAAGGGGGGE NYDDPHKTPA SPVVHIRGLI DGVVEADLVE
       130        140        150        160        170        180
ALQEFGPISY VVVMPKKRQA LVEFEDVLGA CNAVNYAADN QIYIAGHPAF VNYSTSQKIS
       190        200        210        220        230        240
RPGDSDDSRS VNSVLLFTIL NPIYSITTDV LYTICNPCGP VQRIVIFRKN GVQAMVEFDS
       250        260        270        280        290        300
VQSAQRAKAS LNGADIYSGC CTLKIEYAKP TRLNVFKNDQ DTWDYTNPNL SGQGDPGSNP
       310        320        330        340        350        360
NKRQRQPPLL GDHPAEYGGP HGGYHSHYHD EGYGPPPPHY EGRRMGPPVG GHRRGPSRYG
       370        380        390        400        410        420
PQYGHPPPPP PPPEYGPHAD SPVLMVYGLD QSKMNCDRVF NVFCLYGNVE KVKFMKSKPG
       430        440        450        460        470        480
AAMVEMADGY AVDRAITHLN NNFMFGQKLN VCVSKQPAIM PGQSYGLEDG SCSYKDFSES
       490        500        510        520        530        540
RNNRFSTPEQ AAKNRIQHPS NVLHFFNAPL EVTEENFFEI CDELGVKRPS SVKVFSGKSE
       550        560        570        580
RSSSGLLEWE SKSDALETLG FLNHYQMKNP NGPYPYTLKL CFSTAQHAS

Isoforms

- Isoform 2 of Heterogeneous nuclear ribonucleoprotein L

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

36 N-termini - 8 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P14866-1-unknown	MSRRLL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P14866-2-unknown	SRRLLP...	2		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P14866-4-unknown	RLLPRA...	4		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P14866-5-unknown	LLPRAE...	5		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P14866-5-unknown	LLPRAE...	5		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P14866-6-unknown	LPRAEK...	6		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P14866-16-unknown	LEQRQQ...	16		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P14866-32-unknown	MVKMAA...	32	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P14866-33-	VKMAAA...	33		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P14866-33-	VKMAAA...	33		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P14866-33-	VKMAAA...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P14866-33-	VKMAAA...	33		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P14866-35-	MAAAGG...	35		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P14866-35-	MAAAGG...	35		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14866-35-	MAAAGG...	35		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14866-35-	MAAAGG...	35		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14866-36-	AAAGGG...	36		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P14866-36-	AAAGGG...	36		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P14866-36-	AAAGGG...	36		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P14866-36-	AAAGGG...	36		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P14866-36-	AAAGGG...	36		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P14866-36-	AAAGGG...	36		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P14866-36-	AAAGGG...	36		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14866-36-	AAAGGG...	36		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14866-36-	AAAGGG...	36		Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
P14866-36-	AAAGGG...	36		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P14866-36-	AAAGGG...	36		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14866-37-	AAGGGG...	37		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14866-47-	YYGGGS...	47		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P14866-47-	YYGGGS...	47		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P14866-47-	YYGGGS...	47		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14866-82-unknown	AAGGGG...	82	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3651
P14866-82-unknown	AAGGGG...	82	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7340
P14866-93-unknown	DDPHKT...	93	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18758
P14866-93-unknown	DDPHKT...	93	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17365
P14866-118-unknown	LVEALQ...	118	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11222
P14866-134-unknown	MPKKRQ...	134	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77179
P14866-210-unknown	VLYTIC...	210	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11223
P14866-210-unknown	VLYTIC...	210	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141139
P14866-275-	VFKNDQ...	275		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14866-275-unknown	VFKNDQ...	275	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172417
P14866-282-unknown	TWDYTN...	282	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11225
P14866-282-unknown	TWDYTN...	282	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144699
P14866-285-unknown	YTNPNL...	285	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165575
P14866-285-	YTNPNL...	285		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P14866-285-	YTNPNL...	285		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P14866-285-	YTNPNL...	285		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14866-285-	YTNPNL...	285		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14866-285-	YTNPNL...	285		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P14866-285-	YTNPNL...	285		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14866-287-unknown	NPNLSG...	287	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5613
P14866-287-unknown	NPNLSG...	287	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144924
P14866-332-	GYGPPP...	332		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14866-332-unknown	GYGPPP...	332	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175155
P14866-364-	GHPPPP...	364		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P14866-364-	GHPPPP...	364		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14866-364-	GHPPPP...	364		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14866-364-	GHPPPP...	364		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P14866-364-	GHPPPP...	364		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P14866-364-	GHPPPP...	364		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14866-364-unknown	GHPPPP...	364	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166739
P14866-365-unknown	HPPPPP...	365	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3652
P14866-365-unknown	HPPPPP...	365	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5615
P14866-365-unknown	HPPPPP...	365	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147798
P14866-385-	MVYGLD...	385		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14866-385-unknown	MVYGLD...	385	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175157
P14866-426-	MADGYA...	426		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14866-426-unknown	MADGYA...	426	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173176
P14866-473-	SYKDFS...	473		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14866-473-unknown	SYKDFS...	473	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170380
P14866-542-	SSSGLL...	542		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14866-542-unknown	SSSGLL...	542	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177586

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GGGAGA	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3651
...GGGAGA	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7340
...GGENYD	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18758
...GGENYD	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17365
...VVEADL	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11222
...SITTDV	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11223
...SITTDV	209	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124295
...KNDQDT	281	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11225
...KNDQDT	281	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127967
...TWDYTN	286	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5613
...TWDYTN	286	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128200
...GPQYGH	364	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3652
...GPQYGH	364	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5615
...GPQYGH	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131153
...AQHAS	589	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AQHAS	589	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72797

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	81	GAGA.\|.AAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	81	GAGA.\|.AAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	92	ENYD.\|.DDPH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	92	ENYD.\|.DDPH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	117	EADL.\|.LVEA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	209	TTDV.\|.VLYT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	281	DQDT.\|.TWDY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	286	DYTN.\|.NPNL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	364	QYGH.\|.HPPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	364	QYGH.\|.HPPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)