Q00839: Heterogeneous nuclear ribonucleoprotein U {ECO:0000303|PubMed:1628625}

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein U {ECO:0000303\|PubMed:1628625} - hnRNP U {ECO:0000303\|PubMed:1628625} - GRIP120 {ECO:0000303\|PubMed:9353307} - Nuclear p120 ribonucleoprotein {ECO:0000303\|PubMed:7753047} - Scaffold-attachment factor A {ECO:0000303\|PubMed:1324173, ECO:0000303\|Ref.3} - SAF-A {ECO:0000303\|PubMed:1324173, ECO:0000303\|Ref.3} - p120 {ECO:0000303\|PubMed:7993898} - pp120 {ECO:0000303\|PubMed:7993898}
Gene names	HNRNPU
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q00839

55 N-termini

18 C-termini

20 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Short of Heterogeneous nuclear ribonucleoprotein U - Isoform 2 of Heterogeneous nuclear ribonucleoprotein U

Sequence View

        10         20         30         40         50         60
MSSSPVNVKK LKVSELKEEL KKRRLSDKGL KAELMERLQA ALDDEEAGGR PAMEPGNGSL
        70         80         90        100        110        120
DLGGDSAGRS GAGLEQEAAA GGDEEEEEEE EEEEGISALD GDQMELGEEN GAAGAADSGP
       130        140        150        160        170        180
MEEEEAASED ENGDDQGFQE GEDELGDEEE GAGDENGHGE QQPQPPATQQ QQPQQQRGAA
       190        200        210        220        230        240
KEAAGKSSGP TSLFAVTVAP PGARQGQQQA GGKKKAEGGG GGGRPGAPAA GDGKTEQKGG
       250        260        270        280        290        300
DKKRGVKRPR EDHGRGYFEY IEENKYSRAK SPQPPVEEED EHFDDTVVCL DTYNCDLHFK
       310        320        330        340        350        360
ISRDRLSASS LTMESFAFLW AGGRASYGVS KGKVCFEMKV TEKIPVRHLY TKDIDIHEVR
       370        380        390        400        410        420
IGWSLTTSGM LLGEEEFSYG YSLKGIKTCN CETEDYGEKF DENDVITCFA NFESDEVELS
       430        440        450        460        470        480
YAKNGQDLGV AFKISKEVLA GRPLFPHVLC HNCAVEFNFG QKEKPYFPIP EEYTFIQNVP
       490        500        510        520        530        540
LEDRVRGPKG PEEKKDCEVV MMIGLPGAGK TTWVTKHAAE NPGKYNILGT NTIMDKMMVA
       550        560        570        580        590        600
GFKKQMADTG KLNTLLQRAP QCLGKFIEIA ARKKRNFILD QTNVSAAAQR RKMCLFAGFQ
       610        620        630        640        650        660
RKAVVVCPKD EDYKQRTQKK AEVEGKDLPE HAVLKMKGNF TLPEVAECFD EITYVELQKE
       670        680        690        700        710        720
EAQKLLEQYK EESKKALPPE KKQNTGSKKS NKNKSGKNQF NRGGGHRGRG GFNMRGGNFR
       730        740        750        760        770        780
GGAPGNRGGY NRRGNMPQRG GGGGGSGGIG YPYPRAPVFP GRGSYSNRGN YNRGGMPNRG
       790        800        810        820
NYNQNFRGRG NNRGYKNQSQ GYNQWQQGQF WGQKPWSQHY HQGYY         10         20         30         40         50         60
MSSSPVNVKK LKVSELKEEL KKRRLSDKGL KAELMERLQA ALDDEEAGGR PAMEPGNGSL
        70         80         90        100        110        120
DLGGDSAGRS GAGLEQEAAA GGDEEEEEEE EEEEGISALD GDQMELGEEN GAAGAADSGP
       130        140        150        160        170        180
MEEEEAASED ENGDDQGFQE GEDELGDEEE GAGDENGHGE QQPQPPATQQ QQPQQQRGAA
       190        200        210        220        230        240
KEAAGKSSGP TSLFAVTVAP PGARQGQQQA GGKKKAEGGG GGGRPGAPAA GDGKTEQKGG
       250        260        270        280        290        300
DKKRGVKRPR EDHGRGYFEY IEENKYSRAK SPQPPVEEED EHFDDTVVCL DTYNCDLHFK
       310        320        330        340        350        360
ISRDRLSASS LTMESFAFLW AGGRASYGVS KGKVCFEMKV TEKIPVRHLY TKDIDIHEVR
       370        380        390        400        410        420
IGWSLTTSGM LLGEEEFSYG YSLKGIKTCN CETEDYGEKF DENDVITCFA NFESDEVELS
       430        440        450        460        470        480
YAKNGQDLGV AFKISKEVLA GRPLFPHVLC HNCAVEFNFG QKEKPYFPIP EEYTFIQNVP
       490        500        510        520        530        540
LEDRVRGPKG PEEKKDCEVV MMIGLPGAGK TTWVTKHAAE NPGKYNILGT NTIMDKMMVA
       550        560        570        580        590        600
GFKKQMADTG KLNTLLQRAP QCLGKFIEIA ARKKRNFILD QTNVSAAAQR RKMCLFAGFQ
       610        620        630        640        650        660
RKAVVVCPKD EDYKQRTQKK AEVEGKDLPE HAVLKMKGNF TLPEVAECFD EITYVELQKE
       670        680        690        700        710        720
EAQKLLEQYK EESKKALPPE KKQNTGSKKS NKNKSGKNQF NRGGGHRGRG GFNMRGGNFR
       730        740        750        760        770        780
GGAPGNRGGY NRRGNMPQRG GGGGGSGGIG YPYPRAPVFP GRGSYSNRGN YNRGGMPNRG
       790        800        810        820
NYNQNFRGRG NNRGYKNQSQ GYNQWQQGQF WGQKPWSQHY HQGYY

Filter Information:

(REFRESH)

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Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

55 N-termini - 18 C-termini - 20 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q00839-1-unknown	MSSSPV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77190
Q00839-2-unknown	MSSSPV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00839-2-Acetylation	SSSPVN...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00839-2-Acetylation	SSSPVN...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q00839-2-Acetylation	SSSPVN...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q00839-2-Acetylation	SSSPVN...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q00839-2-Acetylation	SSSPVN...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110823
Q00839-29-unknown	GLKAEL...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10177
Q00839-29-unknown	GLKAEL...	29		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137493
Q00839-58-unknown	GSLDLG...	58			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q00839-58-unknown	GSLDLG...	58		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159749
Q00839-58-	GSLDLG...	58			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q00839-58-	GSLDLG...	58			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q00839-58-	GSLDLG...	58			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-58-	GSLDLG...	58			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q00839-58-	GSLDLG...	58			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q00839-58-	GSLDLG...	58			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00839-58-	GSLDLG...	58			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q00839-59-	SLDLGG...	59			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-59-unknown	SLDLGG...	59		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173092
Q00839-66-unknown	SAGRSG...	66		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11861
Q00839-66-unknown	SAGRSG...	66		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140357
Q00839-80-unknown	AGGDEE...	80		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14344
Q00839-80-unknown	AGGDEE...	80		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141279
Q00839-101-unknown	GDQMEL...	101		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1989
Q00839-101-unknown	GDQMEL...	101		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142464
Q00839-157-unknown	GHGEQQ...	157		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166748
Q00839-157-	GHGEQQ...	157			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q00839-157-	GHGEQQ...	157			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-157-	GHGEQQ...	157			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q00839-157-	GHGEQQ...	157			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q00839-157-	GHGEQQ...	157			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00839-157-	GHGEQQ...	157			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q00839-182-	EAAGKS...	182			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q00839-182-	EAAGKS...	182			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q00839-182-	EAAGKS...	182			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q00839-182-	EAAGKS...	182			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q00839-182-unknown	EAAGKS...	182			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q00839-182-unknown	EAAGKS...	182		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161672
Q00839-187-	SSGPTS...	187			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-187-	SSGPTS...	187			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q00839-187-	SSGPTS...	187			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00839-187-unknown	SSGPTS...	187		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170248
Q00839-187-unknown	SSGPTS...	187		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00839-187-unknown	SSGPTS...	187		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q00839-194-unknown	FAVTVA...	194		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14346
Q00839-195-unknown	AVTVAP...	195			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q00839-195-unknown	AVTVAP...	195			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q00839-195-	AVTVAP...	195			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q00839-195-	AVTVAP...	195			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
Q00839-195-	AVTVAP...	195			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q00839-195-	AVTVAP...	195			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q00839-195-	AVTVAP...	195			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q00839-195-	AVTVAP...	195			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-195-	AVTVAP...	195			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q00839-195-	AVTVAP...	195			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q00839-195-	AVTVAP...	195			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00839-195-	AVTVAP...	195			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q00839-195-	AVTVAP...	195			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q00839-215-	KAEGGG...	215			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q00839-218-unknown	GGGGGG...	218		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3945
Q00839-219-unknown	GGGGGR...	219		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6198
Q00839-233-unknown	GKTEQK...	233		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11863
Q00839-233-unknown	GKTEQK...	233		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198339
Q00839-235-unknown	TEQKGG...	235		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10179
Q00839-235-unknown	TEQKGG...	235		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198350
Q00839-256-	GYFEYI...	256			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-256-	GYFEYI...	256			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q00839-256-	GYFEYI...	256			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00839-256-unknown	GYFEYI...	256		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170246
Q00839-256-unknown	GYFEYI...	256		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00839-256-unknown	GYFEYI...	256		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q00839-258-	FEYIEE...	258			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q00839-258-unknown	FEYIEE...	258		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177368
Q00839-259-unknown	EYIEEN...	259		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6199
Q00839-259-unknown	EYIEEN...	259		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19309
Q00839-259-unknown	EYIEEN...	259		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17824
Q00839-259-unknown	EYIEEN...	259		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148075
Q00839-265-unknown	KYSRAK...	265		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14348
Q00839-265-unknown	KYSRAK...	265		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11864
Q00839-265-unknown	KYSRAK...	265		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148280
Q00839-409-	FANFES...	409			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-409-unknown	FANFES...	409		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170244
Q00839-410-	ANFESD...	410			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-410-	ANFESD...	410			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00839-410-unknown	ANFESD...	410		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170250
Q00839-411-	NFESDE...	411			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-411-unknown	NFESDE...	411		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172150
Q00839-441-unknown	GRPLFP...	441		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6201
Q00839-441-unknown	GRPLFP...	441		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152362
Q00839-487-unknown	GPKGPE...	487		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6203
Q00839-487-unknown	GPKGPE...	487		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153048
Q00839-502-	MIGLPG...	502			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00839-502-	MIGLPG...	502			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q00839-502-unknown	MIGLPG...	502		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176646
Q00839-517-	HAAENP...	517			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-517-unknown	HAAENP...	517		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170252
Q00839-544-unknown	KQMADT...	544		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10180
Q00839-544-unknown	KQMADT...	544		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153686
Q00839-549-unknown	TGKLNT...	549		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11866
Q00839-549-unknown	TGKLNT...	549		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153753
Q00839-576-	NFILDQ...	576			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q00839-576-	NFILDQ...	576			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-576-	NFILDQ...	576			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q00839-576-	NFILDQ...	576			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q00839-576-	NFILDQ...	576			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q00839-576-	NFILDQ...	576			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q00839-576-unknown	NFILDQ...	576		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166746
Q00839-602-unknown	KAVVVC...	602		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14350
Q00839-602-unknown	KAVVVC...	602		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154361
Q00839-620-unknown	KAEVEG...	620		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166752
Q00839-620-	KAEVEG...	620			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q00839-620-	KAEVEG...	620			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q00839-625-unknown	GKDLPE...	625		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172152
Q00839-625-	GKDLPE...	625			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q00839-676-unknown	ALPPEK...	676		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177595
Q00839-676-	ALPPEK...	676			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q00839-748-unknown	GIGYPY...	748		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3946
Q00839-748-unknown	GIGYPY...	748		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156124

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RLSDKG	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10177
...RLSDKG	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120463
...DLGGDS	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11861
...DLGGDS	65	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123479
...EQEAAA	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14344
...EQEAAA	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124442
...ISALDG	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1989
...ISALDG	100	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125659
...GPTSLF	193	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14346
...GPTSLF	193	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129677
...KKKAEG	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3945
...KKAEGG	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6198
...PAAGDG	232	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11863
...AGDGKT	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10179
...GRGYFE	258	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6199
...GRGYFE	258	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19309
...GRGYFE	258	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17824
...GRGYFE	258	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131439
...YIEENK	264	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14348
...YIEENK	264	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11864
...YIEENK	264	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131650
...KEVLAG	440	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6201
...KEVLAG	440	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135773
...EDRVRG	486	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6203
...EDRVRG	486	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136473
...VAGFKK	543	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10180
...VAGFKK	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137109
...KQMADT	548	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11866
...KQMADT	548	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137175
...AGFQRK	601	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14350
...AGFQRK	601	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137782
...GGGSGG	747	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3946
...GGGSGG	747	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139587
...HQGYY	825	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HQGYY	825	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72808

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	28	SDKG.\|.GLKA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	65	GGDS.\|.SAGR	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	79	EAAA.\|.AGGD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	100	ALDG.\|.GDQM	inferred from experiment	unknown	MEROPS	Fackelmayer FO	Kipp M et al.:Apoptotic cleavage of scaffold ... (C14.003)	10671544,
GRAM_HUMAN	193	TSLF.\|.FAVT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATB_HUMAN	217	KAEG.\|.GGGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	218	AEGG.\|.GGGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	232	AGDG.\|.GKTE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	234	DGKT.\|.TEQK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATL1_HUMAN	258	GYFE.\|.EYIE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	258	GYFE.\|.EYIE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	258	GYFE.\|.EYIE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	264	EENK.\|.KYSR	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	264	EENK.\|.KYSR	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	440	VLAG.\|.GRPL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	486	RVRG.\|.GPKG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAA_HUMAN	543	GFKK.\|.KQMA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	548	MADT.\|.TGKL	inferred from experiment	unknown	MEROPS		Merops GRAB_HUMAN -> HNRPU_HUMAN @548
GRAB_HUMAN	548	MADT.\|.TGKL	inferred from experiment	unknown	MEROPS	Gevaert K	Plasman K et al.:Probing the efficiency of prote... (S01.010)	21048194,
GRAM_HUMAN	601	FQRK.\|.KAVV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATB_HUMAN	747	GSGG.\|.GIGY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)