Q13444: Disintegrin and metalloproteinase domain-containing protein 15

General Information

Protein names	- Disintegrin and metalloproteinase domain-containing protein 15 - ADAM 15 - 3.4.24.- - Metalloprotease RGD disintegrin protein - Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15 - MDC-15 - Metargidin
Gene names	ADAM15
Organism	Homo sapiens
Protease Family
Protease ID	M12.215
Chromosome location
UniProt ID	Q13444

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 3 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 4 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 5 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 6 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 7 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 8 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 9 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 10 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 11 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 12 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 13 of Disintegrin and metalloproteinase domain-containing protein 15

Sequence View

        10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV
        70         80         90        100        110        120
LQTSLPEPLR IKLELDGDSH ILELLQNREL VPGRPTLVWY QPDGTRVVSE GHTLENCCYQ
       130        140        150        160        170        180
GRVRGYAGSW VSICTCSGLR GLVVLTPERS YTLEQGPGDL QGPPIISRIQ DLHLPGHTCA
       190        200        210        220        230        240
LSWRESVHTQ KPPEHPLGQR HIRRRRDVVT ETKTVELVIV ADHSEAQKYR DFQHLLNRTL
       250        260        270        280        290        300
EVALLLDTFF RPLNVRVALV GLEAWTQRDL VEISPNPAVT LENFLHWRRA HLLPRLPHDS
       310        320        330        340        350        360
AQLVTGTSFS GPTVGMAIQN SICSPDFSGG VNMDHSTSIL GVASSIAHEL GHSLGLDHDL
       370        380        390        400        410        420
PGNSCPCPGP APAKTCIMEA STDFLPGLNF SNCSRRALEK ALLDGMGSCL FERLPSLPPM
       430        440        450        460        470        480
AAFCGNMFVE PGEQCDCGFL DDCVDPCCDS LTCQLRPGAQ CASDGPCCQN CQLRPSGWQC
       490        500        510        520        530        540
RPTRGDCDLP EFCPGDSSQC PPDVSLGDGE PCAGGQAVCM HGRCASYAQQ CQSLWGPGAQ
       550        560        570        580        590        600
PAAPLCLQTA NTRGNAFGSC GRNPSGSYVS CTPRDAICGQ LQCQTGRTQP LLGSIRDLLW
       610        620        630        640        650        660
ETIDVNGTEL NCSWVHLDLG SDVAQPLLTL PGTACGPGLV CIDHRCQRVD LLGAQECRSK
       670        680        690        700        710        720
CHGHGVCDSN RHCYCEEGWA PPDCTTQLKA TSSLTTGLLL SLLVLLVLVM LGASYWYRAR
       730        740        750        760        770        780
LHQRLCQLKG PTCQYRAAQS GPSERPGPPQ RALLARGTKQ ASALSFPAPP SRPLPPDPVS
       790        800        810        820        830        840
KRLQAELADR PNPPTRPLPA DPVVRSPKSQ GPAKPPPPRK PLPADPQGRC PSGDLPGPGA
       850        860
GIPPLVVPSR PAPPPPTVSS LYL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13444-1-unknown	MRLALL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66254
Q13444-1-unknown	MRLALL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66255
Q13444-1-unknown	MRLALL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66256
Q13444-1-unknown	MRLALL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66257
Q13444-1-unknown	MRLALL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66258
Q13444-1-unknown	MRLALL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66259
Q13444-1-unknown	MRLALL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66260
Q13444-1-unknown	MRLALL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66261
Q13444-18-unknown	LPSWPL...	18	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13444-18-unknown	LPSWPL...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112033
Q13444-18-unknown	LPSWPL...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112034
Q13444-18-unknown	LPSWPL...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112035
Q13444-18-unknown	LPSWPL...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112036
Q13444-18-unknown	LPSWPL...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112037
Q13444-18-unknown	LPSWPL...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112038
Q13444-18-unknown	LPSWPL...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112039
Q13444-18-unknown	LPSWPL...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112040
Q13444-51-unknown	DDLPIS...	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19452
Q13444-51-unknown	DDLPIS...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139301
Q13444-51-unknown	DDLPIS...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139302
Q13444-51-unknown	DDLPIS...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139303
Q13444-51-unknown	DDLPIS...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139219
Q13444-51-unknown	DDLPIS...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139220
Q13444-51-unknown	DDLPIS...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139221
Q13444-51-unknown	DDLPIS...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139222
Q13444-51-unknown	DDLPIS...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139224
Q13444-207-unknown	DVVTET...	207	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13444-207-unknown	DVVTET...	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9788
Q13444-207-unknown	DVVTET...	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116026
Q13444-207-unknown	DVVTET...	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116027
Q13444-207-unknown	DVVTET...	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116028
Q13444-207-unknown	DVVTET...	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116029
Q13444-207-unknown	DVVTET...	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116030
Q13444-207-unknown	DVVTET...	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116031
Q13444-207-unknown	DVVTET...	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116032
Q13444-207-unknown	DVVTET...	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116033
Q13444-207-unknown	DVVTET...	207	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PQVLQD	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19452
...PQVLQD	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122376
...PQVLQD	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122377
...PQVLQD	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122378
...PQVLQD	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122294
...PQVLQD	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122295
...PQVLQD	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122296
...PQVLQD	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122297
...PQVLQD	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122299
...IRRRRD	206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9788
...IRRRRD	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130099
...IRRRRD	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130100
...IRRRRD	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130101
...IRRRRD	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130102
...IRRRRD	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130103
...IRRRRD	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130104
...IRRRRD	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130105
...IRRRRD	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130107
...SSLYL	863	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SSLYL	863	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61872
...SSLYL	863	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61875
...SSLYL	863	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61874
...SSLYL	863	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61873

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	50	VLQD.\|.DDLP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
FURIN_HUMAN	206	RRRD.\|.DVVT	inferred from experiment	unknown	MEROPS	Blobel CP	Lum L et al.:Intracellular maturation of the... (S08.071)	9748307,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)