Q07666: KH domain-containing, RNA-binding, signal transduction-associated protein 1

General Information

Protein names	- KH domain-containing, RNA-binding, signal transduction-associated protein 1 - GAP-associated tyrosine phosphoprotein p62 - Src-associated in mitosis 68 kDa protein - Sam68 - p21 Ras GTPase-activating protein-associated p62 - p68
Gene names	KHDRBS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q07666

15 N-termini

6 C-termini

7 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of KH domain-containing, RNA-binding, signal transduction-associated protein 1 - Isoform 3 of KH domain-containing, RNA-binding, signal transduction-associated protein 1

Sequence View

        10         20         30         40         50         60
MQRRDDPAAR MSRSSGRSGS MDPSGAHPSV RQTPSRQPPL PHRSRGGGGG SRGGARASPA
        70         80         90        100        110        120
TQPPPLLPPS ATGPDATVGG PAPTPLLPPS ATASVKMEPE NKYLPELMAE KDSLDPSFTH
       130        140        150        160        170        180
AMQLLTAEIE KIQKGDSKKD DEENYLDLFS HKNMKLKERV LIPVKQYPKF NFVGKILGPQ
       190        200        210        220        230        240
GNTIKRLQEE TGAKISVLGK GSMRDKAKEE ELRKGGDPKY AHLNMDLHVF IEVFGPPCEA
       250        260        270        280        290        300
YALMAHAMEE VKKFLVPDMM DDICQEQFLE LSYLNGVPEP SRGRGVPVRG RGAAPPPPPV
       310        320        330        340        350        360
PRGRGVGPPR GALVRGTPVR GAITRGATVT RGVPPPPTVR GAPAPRARTA GIQRIPLPPP
       370        380        390        400        410        420
PAPETYEEYG YDDTYAEQSY EGYEGYYSQS QGDSEYYDYG HGEVQDSYEA YGQDDWNGTR
       430        440
PSLKAPPARP VKGAYREHPY GRY         10         20         30         40         50         60
MQRRDDPAAR MSRSSGRSGS MDPSGAHPSV RQTPSRQPPL PHRSRGGGGG SRGGARASPA
        70         80         90        100        110        120
TQPPPLLPPS ATGPDATVGG PAPTPLLPPS ATASVKMEPE NKYLPELMAE KDSLDPSFTH
       130        140        150        160        170        180
AMQLLTAEIE KIQKGDSKKD DEENYLDLFS HKNMKLKERV LIPVKQYPKF NFVGKILGPQ
       190        200        210        220        230        240
GNTIKRLQEE TGAKISVLGK GSMRDKAKEE ELRKGGDPKY AHLNMDLHVF IEVFGPPCEA
       250        260        270        280        290        300
YALMAHAMEE VKKFLVPDMM DDICQEQFLE LSYLNGVPEP SRGRGVPVRG RGAAPPPPPV
       310        320        330        340        350        360
PRGRGVGPPR GALVRGTPVR GAITRGATVT RGVPPPPTVR GAPAPRARTA GIQRIPLPPP
       370        380        390        400        410        420
PAPETYEEYG YDDTYAEQSY EGYEGYYSQS QGDSEYYDYG HGEVQDSYEA YGQDDWNGTR
       430        440
PSLKAPPARP VKGAYREHPY GRY

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

15 N-termini - 6 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q07666-1-unknown	MQRRDD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q07666-1-unknown	MQRRDD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78911
Q07666-1-unknown	MQRRDD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78912
Q07666-18-unknown	SGSMDP...	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10213
Q07666-18-unknown	SGSMDP...	18		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q07666-18-unknown	SGSMDP...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136744
Q07666-18-unknown	SGSMDP...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136746
Q07666-18-	SGSMDP...	18		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q07666-18-	SGSMDP...	18		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q07666-18-	SGSMDP...	18		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q07666-18-	SGSMDP...	18		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q07666-20-	SMDPSG...	20		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q07666-20-	SMDPSG...	20		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q07666-20-	SMDPSG...	20		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q07666-20-	SMDPSG...	20		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q07666-20-	SMDPSG...	20		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q07666-20-unknown	SMDPSG...	20	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167020
Q07666-22-unknown	DPSGAH...	22	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19363
Q07666-22-unknown	DPSGAH...	22	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137017
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
Q07666-76-	ATVGGP...	76		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q07666-76-unknown	ATVGGP...	76		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q07666-76-unknown	ATVGGP...	76	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161736
Q07666-76-unknown	ATVGGP...	76	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161735
Q07666-141-unknown	DEENYL...	141	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19366
Q07666-141-unknown	DEENYL...	141	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17859
Q07666-141-unknown	DEENYL...	141	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143285
Q07666-141-unknown	DEENYL...	141	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144367
Q07666-166-	QYPKFN...	166		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q07666-166-	QYPKFN...	166		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q07666-166-unknown	QYPKFN...	166	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165546
Q07666-178-unknown	GPQGNT...	178	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6243
Q07666-178-unknown	GPQGNT...	178	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144851
Q07666-332-unknown	GVPPPP...	332	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170684
Q07666-332-unknown	GVPPPP...	332	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170685
Q07666-332-	GVPPPP...	332		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q07666-415-unknown	DWNGTR...	415	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19369
Q07666-415-unknown	DWNGTR...	415	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17862
Q07666-415-unknown	DWNGTR...	415	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151542
Q07666-415-unknown	DWNGTR...	415	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151844

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RSSGRS	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10213
...RSGSMD	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19363
...RSGSMD	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119860
...RSGSMD	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119861
...DSKKDD	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19366
...DSKKDD	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17859
...DSKKDD	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126515
...DSKKDD	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127629
...VGKILG	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6243
...VGKILG	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128127
...AYGQDD	414	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19369
...AYGQDD	414	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17862
...AYGQDD	414	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134947
...AYGQDD	414	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135250
...PYGRY	443	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PYGRY	443	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74530
...PYGRY	443	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74529

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	17	SGRS.\|.SGSM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1B_HUMAN	21	GSMD.\|.DPSG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	140	KKDD.\|.DEEN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	140	KKDD.\|.DEEN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	177	KILG.\|.GPQG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	414	GQDD.\|.DWNG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	414	GQDD.\|.DWNG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)