P42167: Lamina-associated polypeptide 2, isoforms beta/gamma

General Information

Protein names	- Lamina-associated polypeptide 2, isoforms beta/gamma - Thymopoietin, isoforms beta/gamma - TP beta/gamma - Thymopoietin-related peptide isoforms beta/gamma - TPRP isoforms beta/gamma - Thymopoietin - TP - Splenin - Thymopentin - TP5
Gene names	TMPO
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P42167

14 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Gamma of Lamina-associated polypeptide 2, isoforms beta/gamma - Isoform Zeta of Lamina-associated polypeptide 2, isoforms beta/gamma

Sequence View

        10         20         30         40         50         60
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR PPLPAGTNSK
        70         80         90        100        110        120
GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD KPRQEDKDDL DVTELTNEDL
       130        140        150        160        170        180
LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR EQGTESRSST PLPTISSSAE NTRQNGSNDS
       190        200        210        220        230        240
DRYSDNEEDS KIELKLEKRE PLKGRAKTPV TLKQRRVEHN QSYSQAGITE TEWTSGSSKG
       250        260        270        280        290        300
GPLQALTRES TRGSRRTPRK RVETSEHFRI DGPVISESTP IAETIMASSN ESLVVNRVTG
       310        320        330        340        350        360
NFKHASPILP ITEFSDIPRR APKKPLTRAE VGEKTEERRV ERDILKEMFP YEASTPTGIS
       370        380        390        400        410        420
ASCRRPIKGA AGRPLELSDF RMEESFSSKY VPKYVPLADV KSEKTKKGRS IPVWIKILLF
       430        440        450
VVVAVFLFLV YQAMETNQVN PFSNFLHVDP RKSN         10         20         30         40         50         60
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR PPLPAGTNSK
        70         80         90        100        110        120
GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD KPRQEDKDDL DVTELTNEDL
       130        140        150        160        170        180
LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR EQGTESRSST PLPTISSSAE NTRQNGSNDS
       190        200        210        220        230        240
DRYSDNEEDS KIELKLEKRE PLKGRAKTPV TLKQRRVEHN QSYSQAGITE TEWTSGSSKG
       250        260        270        280        290        300
GPLQALTRES TRGSRRTPRK RVETSEHFRI DGPVISESTP IAETIMASSN ESLVVNRVTG
       310        320        330        340        350        360
NFKHASPILP ITEFSDIPRR APKKPLTRAE VGEKTEERRV ERDILKEMFP YEASTPTGIS
       370        380        390        400        410        420
ASCRRPIKGA AGRPLELSDF RMEESFSSKY VPKYVPLADV KSEKTKKGRS IPVWIKILLF
       430        440        450
VVVAVFLFLV YQAMETNQVN PFSNFLHVDP RKSN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

14 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P42167-1-unknown	MPEFLE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P42167-1-unknown	MPEFLE...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79350
P42167-59-	SKGPPD...	59		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P42167-59-	SKGPPD...	59		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P42167-59-unknown	SKGPPD...	59	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166450
P42167-68-unknown	DEEREP...	68	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19101
P42167-68-unknown	DEEREP...	68	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140507
P42167-94-unknown	KATKKT...	94	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10073
P42167-94-unknown	KATKKT...	94	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142077
P42167-158-unknown	SSTPLP...	158	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10075
P42167-158-unknown	SSTPLP...	158	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145067
P42167-185-unknown	DNEEDS...	185	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17645
P42167-185-unknown	DNEEDS...	185	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146088
P42167-222-	SYSQAG...	222		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P42167-222-	SYSQAG...	222		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P42167-222-	SYSQAG...	222		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P42167-222-	SYSQAG...	222		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P42167-274-	VISEST...	274		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P42167-274-	VISEST...	274		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P42167-274-	VISEST...	274		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P42167-274-	VISEST...	274		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P42167-274-unknown	VISEST...	274		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P42167-369-	GAAGRP...	369		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P42167-369-	GAAGRP...	369		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P42167-369-unknown	GAAGRP...	369	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166452
P42167-372-	GRPLEL...	372		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P42167-372-unknown	GRPLEL...	372	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166454

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PDFSSD	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19101
...PDFSSD	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123635
...AAVGRK	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10073
...AAVGRK	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125261
...GTESRS	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10075
...GTESRS	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128348
...SDRYSD	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17645
...SDRYSD	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129388
...PRKSN	454	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PRKSN	454	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74968

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	67	FSSD.\|.DEER	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAA_HUMAN	93	VGRK.\|.KATK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	157	ESRS.\|.SSTP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1A_HUMAN	184	RYSD.\|.DNEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)