Q9Y3I0: tRNA-splicing ligase RtcB homolog {ECO:0000255|HAMAP-Rule:MF_03144}

General Information

Protein names	- tRNA-splicing ligase RtcB homolog {ECO:0000255\|HAMAP-Rule:MF_03144} - 6.5.1.3 {ECO:0000255\|HAMAP-Rule:MF_03144, ECO:0000269\|PubMed:21311021}
Gene names	RTCB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y3I0

8 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSRSYNDELQ FLEKINKNCW RIKKGFVPNM QVEGVFYVND ALEKLMFEEL RNACRGGGVG
        70         80         90        100        110        120
GFLPAMKQIG NVAALPGIVH RSIGLPDVHS GYGFAIGNMA AFDMNDPEAV VSPGGVGFDI
       130        140        150        160        170        180
NCGVRLLRTN LDESDVQPVK EQLAQAMFDH IPVGVGSKGV IPMNAKDLEE ALEMGVDWSL
       190        200        210        220        230        240
REGYAWAEDK EHCEEYGRML QADPNKVSAR AKKRGLPQLG TLGAGNHYAE IQVVDEIFNE
       250        260        270        280        290        300
YAAKKMGIDH KGQVCVMIHS GSRGLGHQVA TDALVAMEKA MKRDKIIVND RQLACARIAS
       310        320        330        340        350        360
PEGQDYLKGM AAAGNYAWVN RSSMTFLTRQ AFAKVFNTTP DDLDLHVIYD VSHNIAKVEQ
       370        380        390        400        410        420
HVVDGKERTL LVHRKGSTRA FPPHHPLIAV DYQLTGQPVL IGGTMGTCSY VLTGTEQGMT
       430        440        450        460        470        480
ETFGTTCHGA GRALSRAKSR RNLDFQDVLD KLADMGIAIR VASPKLVMEE APESYKNVTD
       490        500
VVNTCHDAGI SKKAIKLRPI AVIKG

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y3I0-1-unknown	MSRSYN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y3I0-4-	SYNDEL...	4		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y3I0-4-	SYNDEL...	4		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y3I0-4-	SYNDEL...	4		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y3I0-74-unknown	ALPGIV...	74	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6941
Q9Y3I0-74-unknown	ALPGIV...	74	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8158
Q9Y3I0-149-unknown	DHIPVG...	149	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19880
Q9Y3I0-227-	HYAEIQ...	227		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y3I0-273-unknown	ALVAME...	273	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13632
Q9Y3I0-335-	VFNTTP...	335		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y3I0-484-unknown	TCHDAG...	484	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6942

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IGNVAA	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6941
...IGNVAA	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8158
...AQAMFD	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19880
...QVATDA	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13632
...TDVVNT	483	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6942
...AVIKG	505	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	73	NVAA.\|.ALPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	73	NVAA.\|.ALPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	148	AMFD.\|.DHIP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	272	ATDA.\|.ALVA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	483	VVNT.\|.TCHD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)