Q15008: 26S proteasome non-ATPase regulatory subunit 6

General Information

Protein names	- 26S proteasome non-ATPase regulatory subunit 6 - 26S proteasome regulatory subunit RPN7 - 26S proteasome regulatory subunit S10 - Breast cancer-associated protein SGA-113M - Phosphonoformate immuno-associated protein 4 - Proteasome regulatory particle subunit p44S10 - p42A
Gene names	PSMD6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15008

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of 26S proteasome non-ATPase regulatory subunit 6 - Isoform 3 of 26S proteasome non-ATPase regulatory subunit 6 - Isoform 4 of 26S proteasome non-ATPase regulatory subunit 6

Sequence View

        10         20         30         40         50         60
MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS
        70         80         90        100        110        120
LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA
       130        140        150        160        170        180
LTAFRKTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL
       190        200        210        220        230        240
KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV
       250        260        270        280        290        300
IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR
       310        320        330        340        350        360
IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEIVETNRPD
       370        380
SKNWQYQETI KKGDLLLNRV QKLSRVINM         10         20         30         40         50         60
MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS
        70         80         90        100        110        120
LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA
       130        140        150        160        170        180
LTAFRKTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL
       190        200        210        220        230        240
KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV
       250        260        270        280        290        300
IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR
       310        320        330        340        350        360
IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEIVETNRPD
       370        380
SKNWQYQETI KKGDLLLNRV QKLSRVINM         10         20         30         40         50         60
MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS
        70         80         90        100        110        120
LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA
       130        140        150        160        170        180
LTAFRKTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL
       190        200        210        220        230        240
KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV
       250        260        270        280        290        300
IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR
       310        320        330        340        350        360
IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEIVETNRPD
       370        380
SKNWQYQETI KKGDLLLNRV QKLSRVINM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15008-1-unknown	MPLENL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15008-2-unknown	PLENLE...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q15008-2-unknown	PLENLE...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15008-2-unknown	PLENLE...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15008-2-unmodified	PLENLE...	2		other		CNRS/ISV	Large_scale_NTA_Human
Q15008-9-unknown	EGLPKN...	9	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19542

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ENLEEE	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19542
...RVINM	389	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RVINM	389	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82017

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	8	LEEE.\|.EGLP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)