P30520: Adenylosuccinate synthetase isozyme 2 {ECO:0000255|HAMAP-Rule:MF_03127}
Protein names | - Adenylosuccinate synthetase isozyme 2 {ECO:0000255|HAMAP-Rule:MF_03127} - AMPSase 2 {ECO:0000255|HAMAP-Rule:MF_03127} - AdSS 2 {ECO:0000255|HAMAP-Rule:MF_03127} - 6.3.4.4 {ECO:0000255|HAMAP-Rule:MF_03127} - Adenylosuccinate synthetase, acidic isozyme {ECO:0000255|HAMAP-Rule:MF_03127} - Adenylosuccinate synthetase, liver isozyme {ECO:0000255|HAMAP-Rule:MF_03127} - L-type adenylosuccinate synthetase {ECO:0000255|HAMAP-Rule:MF_03127} - IMP--aspartate ligase 2 {ECO:0000255|HAMAP-Rule:MF_03127} |
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Gene names | ADSS |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P30520 |
4
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAFAETYPAA SSLPNGDCGR PRARPGGNRV TVVLGAQWGD EGKGKVVDLL AQDADIVCRC
70 80 90 100 110 120
QGGNNAGHTV VVDSVEYDFH LLPSGIINPN VTAFIGNGVV IHLPGLFEEA EKNVQKGKGL
130 140 150 160 170 180
EGWEKRLIIS DRAHIVFDFH QAADGIQEQQ RQEQAGKNLG TTKKGIGPVY SSKAARSGLR
190 200 210 220 230 240
MCDLVSDFDG FSERFKVLAN QYKSIYPTLE IDIEGELQKL KGYMEKIKPM VRDGVYFLYE
250 260 270 280 290 300
ALHGPPKKIL VEGANAALLD IDFGTYPFVT SSNCTVGGVC TGLGMPPQNV GEVYGVVKAY
310 320 330 340 350 360
TTRVGIGAFP TEQDNEIGEL LQTRGREFGV TTGRKRRCGW LDLVLLKYAH MINGFTALAL
370 380 390 400 410 420
TKLDILDMFT EIKVGVAYKL DGEIIPHIPA NQEVLNKVEV QYKTLPGWNT DISNARAFKE
430 440 450
LPVNAQNYVR FIEDELQIPV KWIGVGKSRE SMIQLF
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P30520-1-unknown | MAFAET... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P30520-2-acetylation | AFAETY... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
P30520-2-acetylation | AFAETY... | 2 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
P30520-2-acetylation | AFAETY... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
P30520-141-unknown | QAADGI... | 141 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5779 | |||
P30520-434-unknown | DELQIP... | 434 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19028 | |||
P30520-434-unknown | DELQIP... | 434 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17566 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...VFDFHQ | 140 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5779 | |||
...VRFIED | 433 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19028 | |||
...VRFIED | 433 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17566 | |||
...MIQLF | 456 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...MIQLF | 456 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...MIQLF | 456 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
...MIQLF | 456 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...MIQLF | 456 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 140 | DFHQ.|.QAAD | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
MEP1B_HUMAN | 433 | FIED.|.DELQ | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
MEP1A_HUMAN | 433 | FIED.|.DELQ | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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