P18621: 60S ribosomal protein L17

General Information

Protein names	- 60S ribosomal protein L17 - 60S ribosomal protein L23 - Large ribosomal subunit protein uL22 {ECO:0000303\|PubMed:24524803} - PD-1
Gene names	RPL17
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P18621

14 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of 60S ribosomal protein L17 - Isoform 3 of 60S ribosomal protein L17

Sequence View

        10         20         30         40         50         60
MVRYSLDPEN PTKSCKSRGS NLRVHFKNTR ETAQAIKGMH IRKATKYLKD VTLQKQCVPF
        70         80         90        100        110        120
RRYNGGVGRC AQAKQWGWTQ GRWPKKSAEF LLHMLKNAES NAELKGLDVD SLVIEHIQVN
       130        140        150        160        170        180
KAPKMRRRTY RAHGRINPYM SSPCHIEMIL TEKEQIVPKP EEEVAQKKKI SQKKLKKQKL

MARE         10         20         30         40         50         60
MVRYSLDPEN PTKSCKSRGS NLRVHFKNTR ETAQAIKGMH IRKATKYLKD VTLQKQCVPF
        70         80         90        100        110        120
RRYNGGVGRC AQAKQWGWTQ GRWPKKSAEF LLHMLKNAES NAELKGLDVD SLVIEHIQVN
       130        140        150        160        170        180
KAPKMRRRTY RAHGRINPYM SSPCHIEMIL TEKEQIVPKP EEEVAQKKKI SQKKLKKQKL

MARE

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

14 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P18621-1-unknown	MVRYSL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87818
P18621-2-unknown	VRYSLD...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18621-2-unknown	VRYSLD...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110679
P18621-4-	YSLDPE...	4		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P18621-4-unknown	YSLDPE...	4	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171014
P18621-5-unknown	SLDPEN...	5	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169868
P18621-5-	SLDPEN...	5		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P18621-5-	SLDPEN...	5		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P18621-5-	SLDPEN...	5		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P18621-39-unknown	MHIRKA...	39	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87817
P18621-39-unknown	MHIRKA...	39	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96331
P18621-47-unknown	YLKDVT...	47		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P18621-47-unknown	YLKDVT...	47	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160130
P18621-47-unknown	YLKDVT...	47	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160129
P18621-57-unknown	CVPFRR...	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14024
P18621-57-unknown	CVPFRR...	57	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136800
P18621-57-unknown	CVPFRR...	57	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139699
P18621-109-unknown	VDSLVI...	109	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18819
P18621-109-unknown	VDSLVI...	109	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140733
P18621-109-unknown	VDSLVI...	109	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142882
P18621-111-unknown	SLVIEH...	111	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11303
P18621-111-unknown	SLVIEH...	111	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1148
P18621-111-unknown	SLVIEH...	111		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P18621-111-unknown	SLVIEH...	111	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140819
P18621-111-unknown	SLVIEH...	111	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142986
P18621-111-	SLVIEH...	111		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P18621-111-	SLVIEH...	111		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P18621-111-	SLVIEH...	111		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P18621-154-unknown	EQIVPK...	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164985
P18621-154-	EQIVPK...	154		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P18621-154-	EQIVPK...	154		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TLQKQC	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14024
...TLQKQC	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122798
...LKGLDV	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18819
...LKGLDV	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123868
...LKGLDV	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126090
...GLDVDS	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11303
...GLDVDS	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1148
...GLDVDS	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123958
...GLDVDS	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126194
...LMARE	184	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LMARE	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83435

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	56	QKQC.\|.CVPF	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1B_HUMAN	108	GLDV.\|.VDSL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	110	DVDS.\|.SLVI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP1_HUMAN	110	DVDS.\|.SLVI	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)