P16401: Histone H1.5

General Information

Protein names	- Histone H1.5 - Histone H1a - Histone H1b - Histone H1s-3
Gene names	HIST1H1B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P16401

25 N-termini

12 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSETAPAETA TPAPVEKSPA KKKATKKAAG AGAAKRKATG PPVSELITKA VAASKERNGL
        70         80         90        100        110        120
SLAALKKALA AGGYDVEKNN SRIKLGLKSL VSKGTLVQTK GTGASGSFKL NKKAASGEAK
       130        140        150        160        170        180
PKAKKAGAAK AKKPAGATPK KAKKAAGAKK AVKKTPKKAK KPAAAGVKKV AKSPKKAKAA
       190        200        210        220
AKPKKATKSP AKPKAVKPKA AKPKAAKPKA AKPKAAKAKK AAAKKK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

25 N-termini - 12 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P16401-2-unknown	MSETAP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P16401-2-unknown	MSETAP...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P16401-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P16401-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16401-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P16401-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P16401-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P16401-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P16401-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P16401-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P16401-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P16401-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P16401-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P16401-2-Acetylation	SETAPA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P16401-2-Acetylation	SETAPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P16401-2-Acetylation	SETAPA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P16401-4-	TAPAET...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P16401-21-unknown	KKKATK...	21		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13981
P16401-26-unknown	KKAAGA...	26		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13982
P16401-28-	AAGAGA...	28			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P16401-37-unknown	KATGPP...	37			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P16401-37-	KATGPP...	37			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16401-37-	KATGPP...	37			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P16401-37-	KATGPP...	37			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P16401-37-	KATGPP...	37			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P16401-37-	KATGPP...	37			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P16401-37-	KATGPP...	37			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P16401-38-	ATGPPV...	38			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P16401-40-unknown	GPPVSE...	40		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18798
P16401-40-unknown	GPPVSE...	40		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17393
P16401-47-unknown	ITKAVA...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13983
P16401-48-unknown	TKAVAA...	48		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13984
P16401-59-	GLSLAA...	59			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P16401-61-unknown	SLAALK...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13985
P16401-68-	ALAAGG...	68			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P16401-68-	ALAAGG...	68			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P16401-68-	ALAAGG...	68			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P16401-70-unknown	AAGGYD...	70		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13986
P16401-71-unknown	AGGYDV...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9998
P16401-72-	GGYDVE...	72			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P16401-72-unknown	GGYDVE...	72		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13987
P16401-73-	GYDVEK...	73			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P16401-74-unknown	YDVEKN...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13988
P16401-89-unknown	SLVSKG...	89		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9999
P16401-113-	KAASGE...	113			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16401-131-	AKKPAG...	131			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKSPAK	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13981
...KKKATK	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13982
...KRKATG	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18798
...KRKATG	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17393
...PVSELI	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13983
...VSELIT	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13984
...ERNGLS	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13985
...LKKALA	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13986
...KKALAA	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9998
...KALAAG	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13987
...LAAGGY	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13988
...KLGLKS	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9999
...AAKKK	226	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	20	SPAK.\|.KKKA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	25	KATK.\|.KKAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1B_HUMAN	39	KATG.\|.GPPV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	39	KATG.\|.GPPV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	46	SELI.\|.ITKA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	47	ELIT.\|.TKAV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	60	NGLS.\|.SLAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	69	KALA.\|.AAGG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	70	ALAA.\|.AGGY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	71	LAAG.\|.GGYD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	73	AGGY.\|.YDVE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	88	GLKS.\|.SLVS	inferred from experiment	unknown	MEROPS		Merops GRAA_HUMAN -> H15_HUMAN @88

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)