P68366: Tubulin alpha-4A chain

General Information

Protein names	- Tubulin alpha-4A chain - Alpha-tubulin 1 - Testis-specific alpha-tubulin - Tubulin H2-alpha - Tubulin alpha-1 chain
Gene names	TUBA4A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P68366

35 N-termini

37 C-termini

37 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRECISVHVG QAGVQMGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFT TFFCETGAGK
        70         80         90        100        110        120
HVPRAVFVDL EPTVIDEIRN GPYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDPVLD
       130        140        150        160        170        180
RIRKLSDQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA
       190        200        210        220        230        240
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA
       250        260        270        280        290        300
SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN
       310        320        330        340        350        360
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIAAIKTKRS IQFVDWCPTG FKVGINYQPP
       370        380        390        400        410        420
TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE
       430        440
AREDMAALEK DYEEVGIDSY EDEDEGEE

Isoforms

- Isoform 2 of Tubulin alpha-4A chain

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P68366-1-unknown	MRECIS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P68366-16-unknown	MGNACW...	16	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000375938
P68366-16-unknown	MGNACW...	16	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000408194
P68366-16-unknown	MGNACW...	16	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000396061
P68366-28-unknown	HGIQPD...	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6160
P68366-28-unknown	HGIQPD...	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7676
P68366-57-unknown	GAGKHV...	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15367
P68366-70-unknown	LEPTVI...	70	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11814
P68366-85-unknown	QLFHPE...	85	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10161
P68366-88-unknown	HPEQLI...	88	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6161
P68366-88-unknown	HPEQLI...	88	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7677
P68366-91-unknown	QLITGK...	91	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11815
P68366-93-unknown	ITGKED...	93	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15368
P68366-95-unknown	GKEDAA...	95	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6162
P68366-138-unknown	FHSFGG...	138	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15369
P68366-154-unknown	MERLSV...	154	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000396212
P68366-191-unknown	THTTLE...	191	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6163
P68366-201-unknown	AFMVDN...	201	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15370
P68366-201-unknown	AFMVDN...	201	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14304
P68366-205-unknown	DNEAIY...	205	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15371
P68366-206-unknown	NEAIYD...	206	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11816
P68366-208-unknown	AIYDIC...	208	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11817
P68366-252-unknown	LTEFQT...	252	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11818
P68366-254-unknown	EFQTNL...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15372
P68366-270-unknown	ATYAPV...	270	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14305
P68366-271-unknown	TYAPVI...	271	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6164
P68366-271-unknown	TYAPVI...	271	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3913
P68366-271-unknown	TYAPVI...	271	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19291
P68366-271-unknown	TYAPVI...	271	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7678
P68366-272-unknown	YAPVIS...	272	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3914
P68366-287-unknown	SVAEIT...	287	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14306
P68366-292-unknown	TNACFE...	292	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15373
P68366-321-	GDVVPK...	321		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P68366-353-unknown	VGINYQ...	353	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10162
P68366-354-unknown	GINYQP...	354	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15374
P68366-356-unknown	NYQPPT...	356	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14307
P68366-357-unknown	YQPPTV...	357	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7679
P68366-368-unknown	LAKVQR...	368	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11819
P68366-408-unknown	YVGEGM...	408	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15375
P68366-414-unknown	EEGEFS...	414	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15376
P68366-431-unknown	DYEEVG...	431	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11820
P68366-432-unknown	YEEVGI...	432	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11821
P68366-439-unknown	SYEDED...	439	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11822

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LYCLEH	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6160
...LYCLEH	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7676
...FFCETG	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15367
...AVFVDL	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11814
...NGPYRQ	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10161
...YRQLFH	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6161
...YRQLFH	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7677
...LFHPEQ	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11815
...HPEQLI	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15368
...EQLITG	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6162
...EIIDPV	117	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404740
...QGFLVF	137	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15369
...KSKLEF	168	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396061
...IYPAPQ	175	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000416992
...NSILTT	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6163
...THTTLE	195	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408194
...EHSDCA	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15370
...EHSDCA	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14304
...CAFMVD	204	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15371
...AFMVDN	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11816
...MVDNEA	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11817
...ALNVDL	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11818
...NVDLTE	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15372
...IHFPLA	269	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14305
...HFPLAT	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6164
...HFPLAT	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3913
...HFPLAT	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19291
...HFPLAT	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7678
...FPLATY	271	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3914
...YHEQLS	286	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14306
...SVAEIT	291	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15373
...CDPRHG	309	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396212
...PTGFKV	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10162
...TGFKVG	353	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15374
...FKVGIN	355	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14307
...KVGINY	356	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7679
...VPGGDL	367	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11819
...AFVHWY	407	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15375
...VGEGME	413	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15376
...AALEKD	430	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11820
...ALEKDY	431	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11821
...EVGIDS	438	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11822
...DEGEE	448	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	27	CLEH.\|.HGIQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	27	CLEH.\|.HGIQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
HTRA2_HUMAN	56	CETG.\|.GAGK	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	69	FVDL.\|.LEPT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	84	PYRQ.\|.QLFH	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATL1_HUMAN	87	QLFH.\|.HPEQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	87	QLFH.\|.HPEQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	90	HPEQ.\|.QLIT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	92	EQLI.\|.ITGK	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
CATL1_HUMAN	94	LITG.\|.GKED	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
HTRA2_HUMAN	137	FLVF.\|.FHSF	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
CATL1_HUMAN	190	ILTT.\|.THTT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
HTRA2_HUMAN	200	SDCA.\|.AFMV	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	200	SDCA.\|.AFMV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
HTRA2_HUMAN	204	FMVD.\|.DNEA	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	205	MVDN.\|.NEAI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	207	DNEA.\|.AIYD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	251	NVDL.\|.LTEF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	253	DLTE.\|.EFQT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	269	FPLA.\|.ATYA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	270	PLAT.\|.TYAP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	270	PLAT.\|.TYAP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	270	PLAT.\|.TYAP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	270	PLAT.\|.TYAP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	271	LATY.\|.YAPV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	286	EQLS.\|.SVAE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
HTRA2_HUMAN	291	AEIT.\|.TNAC	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	352	GFKV.\|.VGIN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
HTRA2_HUMAN	353	FKVG.\|.GINY	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	355	VGIN.\|.NYQP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	356	GINY.\|.YQPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	367	GGDL.\|.LAKV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	407	VHWY.\|.YVGE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	413	EGME.\|.EEGE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	430	LEKD.\|.DYEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	431	EKDY.\|.YEEV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	438	GIDS.\|.SYED	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

TopFIND

P68366: Tubulin alpha-4A chain

General Information

35

N-termini

37

C-termini

37

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

35 N-termini - 37 C-termini - 37 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates