P54727: UV excision repair protein RAD23 homolog B

General Information

Protein names	- UV excision repair protein RAD23 homolog B - HR23B - hHR23B - XP-C repair-complementing complex 58 kDa protein - p58
Gene names	RAD23B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P54727

19 N-termini

7 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQVTLKTLQQ QTFKIDIDPE ETVKALKEKI ESEKGKDAFP VAGQKLIYAG KILNDDTALK
        70         80         90        100        110        120
EYKIDEKNFV VVMVTKPKAV STPAPATTQQ SAPASTTAVT SSTTTTVAQA PTPVPALAPT
       130        140        150        160        170        180
STPASITPAS ATASSEPAPA SAAKQEKPAE KPAETPVATS PTATDSTSGD SSRSNLFEDA
       190        200        210        220        230        240
TSALVTGQSY ENMVTEIMSM GYEREQVIAA LRASFNNPDR AVEYLLMGIP GDRESQAVVD
       250        260        270        280        290        300
PPQAASTGAP QSSAVAAAAA TTTATTTTTS SGGHPLEFLR NQPQFQQMRQ IIQQNPSLLP
       310        320        330        340        350        360
ALLQQIGREN PQLLQQISQH QEHFIQMLNE PVQEAGGQGG GGGGGSGGIA EAGSGHMNYI
       370        380        390        400
QVTPQEKEAI ERLKALGFPE GLVIQAYFAC EKNENLAANF LLQQNFDED

Isoforms

- Isoform 2 of UV excision repair protein RAD23 homolog B

Sequence View

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Protein Neighborhood

Domains & Features

19 N-termini - 7 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P54727-1-unknown	MQVTLK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P54727-5-unknown	LKTLQQ...	5	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P54727-49-unknown	AGKILN...	49	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6035
P54727-49-unknown	AGKILN...	49	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7571
P54727-50-unknown	GKILND...	50	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6036
P54727-73-unknown	MVTKPK...	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87223
P54727-125-unknown	SITPAS...	125	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172460
P54727-125-	SITPAS...	125		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P54727-155-	TPVATS...	155		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54727-155-unknown	TPVATS...	155	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182822
P54727-159-unknown	TSPTAT...	159	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7572
P54727-159-unknown	TSPTAT...	159	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6037
P54727-159-unknown	TSPTAT...	159	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141668
P54727-166-	STSGDS...	166		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P54727-166-	STSGDS...	166		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P54727-166-unknown	STSGDS...	166		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P54727-166-unknown	STSGDS...	166	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161982
P54727-260-unknown	ATTTAT...	260	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165779
P54727-260-	ATTTAT...	260		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P54727-260-	ATTTAT...	260		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P54727-261-unknown	TTTATT...	261	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17730
P54727-261-unknown	TTTATT...	261	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146209
P54727-264-unknown	ATTTTT...	264	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172458
P54727-264-	ATTTTT...	264		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P54727-264-	ATTTTT...	264		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P54727-264-	ATTTTT...	264		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P54727-271-unknown	SGGHPL...	271	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19205
P54727-271-unknown	SGGHPL...	271	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17732
P54727-271-unknown	SGGHPL...	271	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146539
P54727-273-unknown	GHPLEF...	273	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17734
P54727-273-unknown	GHPLEF...	273	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146597

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QKLIYA	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6035
...QKLIYA	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7571
...KLIYAG	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6036
...ETPVAT	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7572
...ETPVAT	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6037
...ETPVAT	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124850
...AAAAAT	260	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17730
...AAAAAT	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129512
...TTTTSS	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19205
...TTTTSS	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17732
...TTTTSS	270	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129847
...TTSSGG	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17734
...TTSSGG	272	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129904
...NFDED	409	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NFDED	409	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82841

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	48	LIYA.\|.AGKI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	48	LIYA.\|.AGKI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	49	IYAG.\|.GKIL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	158	PVAT.\|.TSPT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	158	PVAT.\|.TSPT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	260	AAAT.\|.TTTA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	270	TTSS.\|.SGGH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	270	TTSS.\|.SGGH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	272	SSGG.\|.GHPL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)