Q9Y4L1: Hypoxia up-regulated protein 1

General Information

Protein names	- Hypoxia up-regulated protein 1 - 150 kDa oxygen-regulated protein - ORP-150 - 170 kDa glucose-regulated protein - GRP-170
Gene names	HYOU1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y4L1

11 N-termini

13 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADKVRRQRP RRRVCWALVA VLLADLLALS DTLAVMSVDL GSESMKVAIV KPGVPMEIVL
        70         80         90        100        110        120
NKESRRKTPV IVTLKENERF FGDSAASMAI KNPKATLRYF QHLLGKQADN PHVALYQARF
       130        140        150        160        170        180
PEHELTFDPQ RQTVHFQISS QLQFSPEEVL GMVLNYSRSL AEDFAEQPIK DAVITVPVFF
       190        200        210        220        230        240
NQAERRAVLQ AARMAGLKVL QLINDNTATA LSYGVFRRKD INTTAQNIMF YDMGSGSTVC
       250        260        270        280        290        300
TIVTYQMVKT KEAGMQPQLQ IRGVGFDRTL GGLEMELRLR ERLAGLFNEQ RKGQRAKDVR
       310        320        330        340        350        360
ENPRAMAKLL REANRLKTVL SANADHMAQI EGLMDDVDFK AKVTRVEFEE LCADLFERVP
       370        380        390        400        410        420
GPVQQALQSA EMSLDEIEQV ILVGGATRVP RVQEVLLKAV GKEELGKNIN ADEAAAMGAV
       430        440        450        460        470        480
YQAAALSKAF KVKPFVVRDA VVYPILVEFT REVEEEPGIH SLKHNKRVLF SRMGPYPQRK
       490        500        510        520        530        540
VITFNRYSHD FNFHINYGDL GFLGPEDLRV FGSQNLTTVK LKGVGDSFKK YPDYESKGIK
       550        560        570        580        590        600
AHFNLDESGV LSLDRVESVF ETLVEDSAEE ESTLTKLGNT ISSLFGGGTT PDAKENGTDT
       610        620        630        640        650        660
VQEEEESPAE GSKDEPGEQV ELKEEAEAPV EDGSQPPPPE PKGDATPEGE KATEKENGDK
       670        680        690        700        710        720
SEAQKPSEKA EAGPEGVAPA PEGEKKQKPA RKRRMVEEIG VELVVLDLPD LPEDKLAQSV
       730        740        750        760        770        780
QKLQDLTLRD LEKQEREKAA NSLEAFIFET QDKLYQPEYQ EVSTEEQREE ISGKLSAAST
       790        800        810        820        830        840
WLEDEGVGAT TVMLKEKLAE LRKLCQGLFF RVEERKKWPE RLSALDNLLN HSSMFLKGAR
       850        860        870        880        890        900
LIPEMDQIFT EVEMTTLEKV INETWAWKNA TLAEQAKLPA TEKPVLLSKD IEAKMMALDR
       910        920        930        940        950        960
EVQYLLNKAK FTKPRPRPKD KNGTRAEPPL NASASDQGEK VIPPAGQTED AEPISEPEKV
       970        980        990
ETGSEPGDTE PLELGGPGAE PEQKEQSTGQ KRPLKNDEL

Isoforms

- Isoform 2 of Hypoxia up-regulated protein 1

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Evidence Names:

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Protein Neighborhood

Domains & Features

11 N-termini - 13 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y4L1-33-unknown	LAVMSV...	33	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y4L1-33-unknown	LAVMSV...	33	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q9Y4L1-33-	LAVMSV...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y4L1-33-	LAVMSV...	33		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9Y4L1-33-	LAVMSV...	33		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y4L1-34-	AVMSVD...	34		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y4L1-37-	SVDLGS...	37		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y4L1-88-unknown	MAIKNP...	88	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442727
Q9Y4L1-339-unknown	FKAKVT...	339	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2361
Q9Y4L1-399-	AVGKEE...	399		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y4L1-558-	SVFETL...	558		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y4L1-558-	SVFETL...	558		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y4L1-567-	SAEEES...	567		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y4L1-663-	AQKPSE...	663		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y4L1-707-unknown	DLPDLP...	707	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18186
Q9Y4L1-707-unknown	DLPDLP...	707	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19882

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MAIKNP	92	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000462510
...MAIKNP	92	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463547
...RYFQHL	102	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000462771
...RYFQHL	102	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463563
...SPEEVL	149	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463742
...SPEEVL	149	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000462893
...LGMVLN	154	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463515
...LNYSRS	158	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464115
...TATALS	211	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463318
...DINTTA	224	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000462951
...DINTTA	224	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000462844
...MDDVDF	338	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2361
...GEKATE	653	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000459093
...ATEKEN	656	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431874
...ELVVLD	706	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18186
...ELVVLD	706	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19882
...KNDEL	999	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KNDEL	999		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KNDEL	999		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	338	DVDF.\|.FKAK	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> HYOU1_HUMAN @338
MEP1A_HUMAN	706	VVLD.\|.DLPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	706	VVLD.\|.DLPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)