P17174: Aspartate aminotransferase, cytoplasmic

General Information

Protein names	- Aspartate aminotransferase, cytoplasmic - cAspAT - 2.6.1.1 - 2.6.1.3 - Cysteine aminotransferase, cytoplasmic - Cysteine transaminase, cytoplasmic - cCAT - Glutamate oxaloacetate transaminase 1 - Transaminase A
Gene names	GOT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P17174

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPPSVFAEV PQAQPVLVFK LTADFREDPD PRKVNLGVGA YRTDDCHPWV LPVVKKVEQK
        70         80         90        100        110        120
IANDNSLNHE YLPILGLAEF RSCASRLALG DDSPALKEKR VGGVQSLGGT GALRIGADFL
       130        140        150        160        170        180
ARWYNGTNNK NTPVYVSSPT WENHNAVFSA AGFKDIRSYR YWDAEKRGLD LQGFLNDLEN
       190        200        210        220        230        240
APEFSIVVLH ACAHNPTGID PTPEQWKQIA SVMKHRFLFP FFDSAYQGFA SGNLERDAWA
       250        260        270        280        290        300
IRYFVSEGFE FFCAQSFSKN FGLYNERVGN LTVVGKEPES ILQVLSQMEK IVRITWSNPP
       310        320        330        340        350        360
AQGARIVAST LSNPELFEEW TGNVKTMADR ILTMRSELRA RLEALKTPGT WNHITDQIGM
       370        380        390        400        410
FSFTGLNPKQ VEYLVNEKHI YLLPSGRINV SGLTTKNLDY VATSIHEAVT KIQ

Isoforms

- Isoform 2 of Aspartate aminotransferase, cytoplasmic

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P17174-2-unmodified	APPSVF...	2		other		CNRS/ISV	Large_scale_NTA_Human
P17174-2-	APPSVF...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P17174-2-unknown	APPSVF...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P17174-5-	SVFAEV...	5		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P17174-5-	SVFAEV...	5		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P17174-5-	SVFAEV...	5		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P17174-5-	SVFAEV...	5		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P17174-5-	SVFAEV...	5		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P17174-5-	SVFAEV...	5		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P17174-45-unknown	DCHPWV...	45	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18808
P17174-119-unknown	FLARWY...	119	inferred from electronic annotation	unknown	TISdb		inferred from TISdb

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...AYRTDD	44	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18808
	...VTKIQ	413	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	44	RTDD.\|.DCHP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)