O76021: Ribosomal L1 domain-containing protein 1

General Information

Protein names	- Ribosomal L1 domain-containing protein 1 - CATX-11 - Cellular senescence-inhibited gene protein {ECO:0000303\|PubMed:18678645} - Protein PBK1
Gene names	RSL1D1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O76021

19 N-termini

11 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEDSASASLS SAAATGTSTS TPAAPTARKQ LDKEQVRKAV DALLTHCKSR KNNYGLLLNE
        70         80         90        100        110        120
NESLFLMVVL WKIPSKELRV RLTLPHSIRS DSEDICLFTK DEPNSTPEKT EQFYRKLLNK
       130        140        150        160        170        180
HGIKTVSQII SLQTLKKEYK SYEAKLRLLS SFDFFLTDAR IRRLLPSLIG RHFYQRKKVP
       190        200        210        220        230        240
VSVNLLSKNL SREINDCIGG TVLNISKSGS CSAIRIGHVG MQIEHIIENI VAVTKGLSEK
       250        260        270        280        290        300
LPEKWESVKL LFVKTEKSAA LPIFSSFVSN WDEATKRSLL NKKKKEARRK RRERNFEKQK
       310        320        330        340        350        360
ERKKKRQQAR KTASVLSKDD VAPESGDTTV KKPESKKEQT PEHGKKKRGR GKAQVKATNE
       370        380        390        400        410        420
SEDEIPQLVP IGKKTPANEK VEIQKHATGK KSPAKSPNPS TPRGKKRKAL PASETPKAAE
       430        440        450        460        470        480
SETPGKSPEK KPKIKEEAVK EKSPSLGKKD ARQTPKKPEA KFFTTPSKSV RKASHTPKKW
       490
PKKPKVPQST

Isoforms

- Isoform 2 of Ribosomal L1 domain-containing protein 1

Sequence View

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Protein Neighborhood

Domains & Features

19 N-termini - 11 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O76021-1-Acetylation	MEDSAS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O76021-1-Acetylation	MEDSAS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O76021-1-Acetylation	MEDSAS...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O76021-1-Acetylation	MEDSAS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O76021-4-unknown	SASASL...	4		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10978
O76021-11-	SAAATG...	11			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O76021-11-	SAAATG...	11			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O76021-11-	SAAATG...	11			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O76021-12-	AAATGT...	12			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O76021-12-	AAATGT...	12			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O76021-12-	AAATGT...	12			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O76021-12-	AAATGT...	12			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O76021-13-	AATGTS...	13			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O76021-13-	AATGTS...	13			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O76021-14-	ATGTST...	14			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O76021-16-	GTSTST...	16			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O76021-20-	STPAAP...	20			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O76021-67-unknown	MVVLWK...	67		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000459331
O76021-221-unknown	MQIEHI...	221		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442089
O76021-269-unknown	SNWDEA...	269		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5273
O76021-280-unknown	LNKKKK...	280		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13852
O76021-314-	SVLSKD...	314			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O76021-320-unknown	DVAPES...	320		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10979
O76021-325-unknown	SGDTTV...	325		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10980
O76021-357-	ATNESE...	357			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O76021-422-unknown	ETPGKS...	422		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18323
O76021-438-unknown	AVKEKS...	438		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10981
O76021-462-	FFTTPS...	462			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RIRRLL	164	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000459331
...KNLSRE	192	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460343
...FSSFVS	268	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5273
...TKRSLL	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13852
...VLSKDD	319	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10979
...DVAPES	324	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10980
...GDTTVK	330	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460748
...KAAESE	421	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18323
...SPEKKP	431	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000347897
...KIKEEA	437	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10981
...VPQST	490	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	3	MEDS.\|.SASA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	268	SFVS.\|.SNWD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	279	RSLL.\|.LNKK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	319	SKDD.\|.DVAP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	324	APES.\|.SGDT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1B_HUMAN	421	AESE.\|.ETPG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	437	KEEA.\|.AVKE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)