Q9UHB9: Signal recognition particle subunit SRP68

General Information

Protein names	- Signal recognition particle subunit SRP68 - SRP68 - Signal recognition particle 68 kDa protein
Gene names	SRP68
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UHB9

15 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Signal recognition particle subunit SRP68 - Isoform 3 of Signal recognition particle subunit SRP68 - Isoform 4 of Signal recognition particle subunit SRP68

Sequence View

        10         20         30         40         50         60
MAAEKQVPGG GGGGGSGGGG GSGGGGSGGG RGAGGEENKE NERPSAGSKA NKEFGDSLSL
        70         80         90        100        110        120
EILQIIKESQ QQHGLRHGDF QRYRGYCSRR QRRLRKTLNF KMGNRHKFTG KKVTEELLTD
       130        140        150        160        170        180
NRYLLLVLMD AERAWSYAMQ LKQEANTEPR KRFHLLSRLR KAVKHAEELE RLCESNRVDA
       190        200        210        220        230        240
KTKLEAQAYT AYLSGMLRFE HQEWKAAIEA FNKCKTIYEK LASAFTEEQA VLYNQRVEEI
       250        260        270        280        290        300
SPNIRYCAYN IGDQSAINEL MQMRLRSGGT EGLLAEKLEA LITQTRAKQA ATMSEVEWRG
       310        320        330        340        350        360
RTVPVKIDKV RIFLLGLADN EAAIVQAESE ETKERLFESM LSECRDAIQV VREELKPDQK
       370        380        390        400        410        420
QRDYILEGEP GKVSNLQYLH SYLTYIKLST AIKRNENMAK GLQRALLQQQ PEDDSKRSPR
       430        440        450        460        470        480
PQDLIRLYDI ILQNLVELLQ LPGLEEDKAF QKEIGLKTLV FKAYRCFFIA QSYVLVKKWS
       490        500        510        520        530        540
EALVLYDRVL KYANEVNSDA GAFKNSLKDL PDVQELITQV RSEKCSLQAA AILDANDAHQ
       550        560        570        580        590        600
TETSSSQVKD NKPLVERFET FCLDPSLVTK QANLVHFPPG FQPIPCKPLF FDLALNHVAF
       610        620
PPLEDKLEQK TKSGLTGYIK GIFGFRS         10         20         30         40         50         60
MAAEKQVPGG GGGGGSGGGG GSGGGGSGGG RGAGGEENKE NERPSAGSKA NKEFGDSLSL
        70         80         90        100        110        120
EILQIIKESQ QQHGLRHGDF QRYRGYCSRR QRRLRKTLNF KMGNRHKFTG KKVTEELLTD
       130        140        150        160        170        180
NRYLLLVLMD AERAWSYAMQ LKQEANTEPR KRFHLLSRLR KAVKHAEELE RLCESNRVDA
       190        200        210        220        230        240
KTKLEAQAYT AYLSGMLRFE HQEWKAAIEA FNKCKTIYEK LASAFTEEQA VLYNQRVEEI
       250        260        270        280        290        300
SPNIRYCAYN IGDQSAINEL MQMRLRSGGT EGLLAEKLEA LITQTRAKQA ATMSEVEWRG
       310        320        330        340        350        360
RTVPVKIDKV RIFLLGLADN EAAIVQAESE ETKERLFESM LSECRDAIQV VREELKPDQK
       370        380        390        400        410        420
QRDYILEGEP GKVSNLQYLH SYLTYIKLST AIKRNENMAK GLQRALLQQQ PEDDSKRSPR
       430        440        450        460        470        480
PQDLIRLYDI ILQNLVELLQ LPGLEEDKAF QKEIGLKTLV FKAYRCFFIA QSYVLVKKWS
       490        500        510        520        530        540
EALVLYDRVL KYANEVNSDA GAFKNSLKDL PDVQELITQV RSEKCSLQAA AILDANDAHQ
       550        560        570        580        590        600
TETSSSQVKD NKPLVERFET FCLDPSLVTK QANLVHFPPG FQPIPCKPLF FDLALNHVAF
       610        620
PPLEDKLEQK TKSGLTGYIK GIFGFRS         10         20         30         40         50         60
MAAEKQVPGG GGGGGSGGGG GSGGGGSGGG RGAGGEENKE NERPSAGSKA NKEFGDSLSL
        70         80         90        100        110        120
EILQIIKESQ QQHGLRHGDF QRYRGYCSRR QRRLRKTLNF KMGNRHKFTG KKVTEELLTD
       130        140        150        160        170        180
NRYLLLVLMD AERAWSYAMQ LKQEANTEPR KRFHLLSRLR KAVKHAEELE RLCESNRVDA
       190        200        210        220        230        240
KTKLEAQAYT AYLSGMLRFE HQEWKAAIEA FNKCKTIYEK LASAFTEEQA VLYNQRVEEI
       250        260        270        280        290        300
SPNIRYCAYN IGDQSAINEL MQMRLRSGGT EGLLAEKLEA LITQTRAKQA ATMSEVEWRG
       310        320        330        340        350        360
RTVPVKIDKV RIFLLGLADN EAAIVQAESE ETKERLFESM LSECRDAIQV VREELKPDQK
       370        380        390        400        410        420
QRDYILEGEP GKVSNLQYLH SYLTYIKLST AIKRNENMAK GLQRALLQQQ PEDDSKRSPR
       430        440        450        460        470        480
PQDLIRLYDI ILQNLVELLQ LPGLEEDKAF QKEIGLKTLV FKAYRCFFIA QSYVLVKKWS
       490        500        510        520        530        540
EALVLYDRVL KYANEVNSDA GAFKNSLKDL PDVQELITQV RSEKCSLQAA AILDANDAHQ
       550        560        570        580        590        600
TETSSSQVKD NKPLVERFET FCLDPSLVTK QANLVHFPPG FQPIPCKPLF FDLALNHVAF
       610        620
PPLEDKLEQK TKSGLTGYIK GIFGFRS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

15 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UHB9-1-unknown	MAAEKQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UHB9-1-unknown	MAAEKQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90688
Q9UHB9-1-unknown	MAAEKQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90690
Q9UHB9-2-unknown	AAEKQV...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UHB9-2-unknown	AAEKQV...	2		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173293
Q9UHB9-2-unknown	AAEKQV...	2		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173294
Q9UHB9-2-acetylation	AAEKQV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UHB9-2-acetylation	AAEKQV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162984
Q9UHB9-2-acetylation	AAEKQV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162985
Q9UHB9-2-	AAEKQV...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UHB9-2-	AAEKQV...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UHB9-35-unknown	GEENKE...	35		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19845
Q9UHB9-35-unknown	GEENKE...	35		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137973
Q9UHB9-35-unknown	GEENKE...	35		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137975
Q9UHB9-155-unknown	LLSRLR...	155		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q9UHB9-155-unknown	LLSRLR...	155		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197668
Q9UHB9-155-unknown	LLSRLR...	155		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197669
Q9UHB9-316-unknown	GLADNE...	316		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173296
Q9UHB9-316-unknown	GLADNE...	316		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173297
Q9UHB9-316-	GLADNE...	316			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UHB9-340-unknown	MLSECR...	340		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90689
Q9UHB9-340-unknown	MLSECR...	340		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99517
Q9UHB9-340-unknown	MLSECR...	340		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99518
Q9UHB9-500-unknown	AGAFKN...	500		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13517
Q9UHB9-500-unknown	AGAFKN...	500		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145192
Q9UHB9-500-unknown	AGAFKN...	500		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152937
Q9UHB9-500-unknown	AGAFKN...	500		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153072
Q9UHB9-531-	AILDAN...	531			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UHB9-531-unknown	AILDAN...	531		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170778
Q9UHB9-531-unknown	AILDAN...	531		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170777
Q9UHB9-531-unknown	AILDAN...	531		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170779
Q9UHB9-535-unknown	ANDAHQ...	535		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8132
Q9UHB9-535-unknown	ANDAHQ...	535		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146477
Q9UHB9-535-unknown	ANDAHQ...	535		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153386
Q9UHB9-535-unknown	ANDAHQ...	535		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153465
Q9UHB9-538-unknown	AHQTET...	538		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165798
Q9UHB9-538-unknown	AHQTET...	538		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165797
Q9UHB9-538-unknown	AHQTET...	538		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165799
Q9UHB9-538-	AHQTET...	538			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9UHB9-538-	AHQTET...	538			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9UHB9-538-	AHQTET...	538			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UHB9-538-	AHQTET...	538			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UHB9-538-	AHQTET...	538			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UHB9-538-	AHQTET...	538			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
Q9UHB9-538-	AHQTET...	538			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GRGAGG	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19845
...GRGAGG	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120982
...GRGAGG	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120984
...EVNSDA	499	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13517
...EVNSDA	499	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128480
...EVNSDA	499	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136363
...EVNSDA	499	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136497
...AAILDA	534	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8132
...AAILDA	534	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129785
...AAILDA	534	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136811
...AAILDA	534	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136888
...FGFRS	627	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FGFRS	627	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86307
...FGFRS	627	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86308
...FGFRS	627	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86306

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	34	GAGG.\|.GEEN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	499	NSDA.\|.AGAF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	534	ILDA.\|.ANDA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)