P55060: Exportin-2

General Information

Protein names	- Exportin-2 - Exp2 - Cellular apoptosis susceptibility protein {ECO:0000303\|PubMed:7479798} - Chromosome segregation 1-like protein - Importin-alpha re-exporter
Gene names	CSE1L
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P55060

4 N-termini

2 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Exportin-2 - Isoform 3 of Exportin-2 - Isoform 4 of Exportin-2

Sequence View

        10         20         30         40         50         60
MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL EKSQDNVIKV
        70         80         90        100        110        120
CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM LSSPEQIQKQ LSDAISIIGR
       130        140        150        160        170        180
EDFPQKWPDL LTEMVNRFQS GDFHVINGVL RTAHSLFKRY RHEFKSNELW TEIKLVLDAF
       190        200        210        220        230        240
ALPLTNLFKA TIELCSTHAN DASALRILFS SLILISKLFY SLNFQDLPEF FEDNMETWMN
       250        260        270        280        290        300
NFHTLLTLDN KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQRYL PRFVTAIWNL
       310        320        330        340        350        360
LVTTGQEVKY DLLVSNAIQF LASVCERPHY KNLFEDQNTL TSICEKVIVP NMEFRAADEE
       370        380        390        400        410        420
AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP VTGIFSGYVN SMLQEYAKNP
       430        440        450        460        470        480
SVNWKHKDAA IYLVTSLASK AQTQKHGITQ ANELVNLTEF FVNHILPDLK SANVNEFPVL
       490        500        510        520        530        540
KADGIKYIMI FRNQVPKEHL LVSIPLLINH LQAESIVVHT YAAHALERLF TMRGPNNATL
       550        560        570        580        590        600
FTAAEIAPFV EILLTNLFKA LTLPGSSENE YIMKAIMRSF SLLQEAIIPY IPTLITQLTQ
       610        620        630        640        650        660
KLLAVSKNPS KPHFNHYMFE AICLSIRITC KANPAAVVNF EEALFLVFTE ILQNDVQEFI
       670        680        690        700        710        720
PYVFQVMSLL LETHKNDIPS SYMALFPHLL QPVLWERTGN IPALVRLLQA FLERGSNTIA
       730        740        750        760        770        780
SAAADKIPGL LGVFQKLIAS KANDHQGFYL LNSIIEHMPP ESVDQYRKQI FILLFQRLQN
       790        800        810        820        830        840
SKTTKFIKSF LVFINLYCIK YGALALQEIF DGIQPKMFGM VLEKIIIPEI QKVSGNVEKK
       850        860        870        880        890        900
ICAVGITKLL TECPPMMDTE YTKLWTPLLQ SLIGLFELPE DDTIPDEEHF IDIEDTPGYQ
       910        920        930        940        950        960
TAFSQLAFAG KKEHDPVGQM VNNPKIHLAQ SLHKLSTACP GRVPSMVSTS LNAEALQYLQ
       970
GYLQAASVTL L         10         20         30         40         50         60
MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL EKSQDNVIKV
        70         80         90        100        110        120
CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM LSSPEQIQKQ LSDAISIIGR
       130        140        150        160        170        180
EDFPQKWPDL LTEMVNRFQS GDFHVINGVL RTAHSLFKRY RHEFKSNELW TEIKLVLDAF
       190        200        210        220        230        240
ALPLTNLFKA TIELCSTHAN DASALRILFS SLILISKLFY SLNFQDLPEF FEDNMETWMN
       250        260        270        280        290        300
NFHTLLTLDN KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQRYL PRFVTAIWNL
       310        320        330        340        350        360
LVTTGQEVKY DLLVSNAIQF LASVCERPHY KNLFEDQNTL TSICEKVIVP NMEFRAADEE
       370        380        390        400        410        420
AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP VTGIFSGYVN SMLQEYAKNP
       430        440        450        460        470        480
SVNWKHKDAA IYLVTSLASK AQTQKHGITQ ANELVNLTEF FVNHILPDLK SANVNEFPVL
       490        500        510        520        530        540
KADGIKYIMI FRNQVPKEHL LVSIPLLINH LQAESIVVHT YAAHALERLF TMRGPNNATL
       550        560        570        580        590        600
FTAAEIAPFV EILLTNLFKA LTLPGSSENE YIMKAIMRSF SLLQEAIIPY IPTLITQLTQ
       610        620        630        640        650        660
KLLAVSKNPS KPHFNHYMFE AICLSIRITC KANPAAVVNF EEALFLVFTE ILQNDVQEFI
       670        680        690        700        710        720
PYVFQVMSLL LETHKNDIPS SYMALFPHLL QPVLWERTGN IPALVRLLQA FLERGSNTIA
       730        740        750        760        770        780
SAAADKIPGL LGVFQKLIAS KANDHQGFYL LNSIIEHMPP ESVDQYRKQI FILLFQRLQN
       790        800        810        820        830        840
SKTTKFIKSF LVFINLYCIK YGALALQEIF DGIQPKMFGM VLEKIIIPEI QKVSGNVEKK
       850        860        870        880        890        900
ICAVGITKLL TECPPMMDTE YTKLWTPLLQ SLIGLFELPE DDTIPDEEHF IDIEDTPGYQ
       910        920        930        940        950        960
TAFSQLAFAG KKEHDPVGQM VNNPKIHLAQ SLHKLSTACP GRVPSMVSTS LNAEALQYLQ
       970
GYLQAASVTL L         10         20         30         40         50         60
MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL EKSQDNVIKV
        70         80         90        100        110        120
CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM LSSPEQIQKQ LSDAISIIGR
       130        140        150        160        170        180
EDFPQKWPDL LTEMVNRFQS GDFHVINGVL RTAHSLFKRY RHEFKSNELW TEIKLVLDAF
       190        200        210        220        230        240
ALPLTNLFKA TIELCSTHAN DASALRILFS SLILISKLFY SLNFQDLPEF FEDNMETWMN
       250        260        270        280        290        300
NFHTLLTLDN KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQRYL PRFVTAIWNL
       310        320        330        340        350        360
LVTTGQEVKY DLLVSNAIQF LASVCERPHY KNLFEDQNTL TSICEKVIVP NMEFRAADEE
       370        380        390        400        410        420
AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP VTGIFSGYVN SMLQEYAKNP
       430        440        450        460        470        480
SVNWKHKDAA IYLVTSLASK AQTQKHGITQ ANELVNLTEF FVNHILPDLK SANVNEFPVL
       490        500        510        520        530        540
KADGIKYIMI FRNQVPKEHL LVSIPLLINH LQAESIVVHT YAAHALERLF TMRGPNNATL
       550        560        570        580        590        600
FTAAEIAPFV EILLTNLFKA LTLPGSSENE YIMKAIMRSF SLLQEAIIPY IPTLITQLTQ
       610        620        630        640        650        660
KLLAVSKNPS KPHFNHYMFE AICLSIRITC KANPAAVVNF EEALFLVFTE ILQNDVQEFI
       670        680        690        700        710        720
PYVFQVMSLL LETHKNDIPS SYMALFPHLL QPVLWERTGN IPALVRLLQA FLERGSNTIA
       730        740        750        760        770        780
SAAADKIPGL LGVFQKLIAS KANDHQGFYL LNSIIEHMPP ESVDQYRKQI FILLFQRLQN
       790        800        810        820        830        840
SKTTKFIKSF LVFINLYCIK YGALALQEIF DGIQPKMFGM VLEKIIIPEI QKVSGNVEKK
       850        860        870        880        890        900
ICAVGITKLL TECPPMMDTE YTKLWTPLLQ SLIGLFELPE DDTIPDEEHF IDIEDTPGYQ
       910        920        930        940        950        960
TAFSQLAFAG KKEHDPVGQM VNNPKIHLAQ SLHKLSTACP GRVPSMVSTS LNAEALQYLQ
       970
GYLQAASVTL L

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P55060-1-unknown	MELSDA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94726
P55060-1-unknown	MELSDA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94727
P55060-1-unknown	MELSDA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94728
P55060-1-Acetylation	MELSDA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55060-1-Acetylation	MELSDA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P55060-1-Acetylation	MELSDA...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P55060-1-Acetylation	MELSDA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P55060-1-Acetylation	MELSDA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107925
P55060-1-Acetylation	MELSDA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107926
P55060-1-Acetylation	MELSDA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107927
P55060-5-unknown	DANLQT...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19210
P55060-5-unknown	DANLQT...	5		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194650
P55060-5-unknown	DANLQT...	5		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194651
P55060-5-unknown	DANLQT...	5		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194652
P55060-196-unknown	STHAND...	196		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6043
P55060-196-unknown	STHAND...	196		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7579
P55060-196-unknown	STHAND...	196		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146470
P55060-196-unknown	STHAND...	196		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146471

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TIELCS	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6043
...TIELCS	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7579
...TIELCS	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129778
...TIELCS	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129779
...SVTLL	971	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SVTLL	971	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90346

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	4	ELSD.\|.DANL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	195	ELCS.\|.STHA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	195	ELCS.\|.STHA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)