O43390: Heterogeneous nuclear ribonucleoprotein R

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein R - hnRNP R
Gene names	HNRNPR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43390

20 N-termini

13 C-termini

15 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Heterogeneous nuclear ribonucleoprotein R - Isoform 3 of Heterogeneous nuclear ribonucleoprotein R - Isoform 4 of Heterogeneous nuclear ribonucleoprotein R

Sequence View

        10         20         30         40         50         60
MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF QTGLVAYVDL
        70         80         90        100        110        120
DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG VMKTYRQREK QGSKVQESTK
       130        140        150        160        170        180
GPDEAKIKAL LERTGYTLDV TTGQRKYGGP PPDSVYSGVQ PGIGTEVFVG KIPRDLYEDE
       190        200        210        220        230        240
LVPLFEKAGP IWDLRLMMDP LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC
       250        260        270        280        290        300
ISVANNRLFV GSIPKNKTKE NILEEFSKVT EGLVDVILYH QPDDKKKNRG FCFLEYEDHK
       310        320        330        340        350        360
SAAQARRRLM SGKVKVWGNV VTVEWADPVE EPDPEVMAKV KVLFVRNLAT TVTEEILEKS
       370        380        390        400        410        420
FSEFGKLERV KKLKDYAFVH FEDRGAAVKA MDEMNGKEIE GEEIEIVLAK PPDKKRKERQ
       430        440        450        460        470        480
AARQASRSTA YEDYYYHPPP RMPPPIRGRG RGGGRGGYGY PPDYYGYEDY YDDYYGYDYH
       490        500        510        520        530        540
DYRGGYEDPY YGYDDGYAVR GRGGGRGGRG APPPPRGRGA PPPRGRAGYS QRGAPLGPPR
       550        560        570        580        590        600
GSRGGRGGPA QQQRGRGSRG SRGNRGGNVG GKRKADGYNQ PDSKRRQTNN QQNWGSQPIA
       610        620        630
QQPLQQGGDY SGNYGYNNDN QEFYQDTYGQ QWK         10         20         30         40         50         60
MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF QTGLVAYVDL
        70         80         90        100        110        120
DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG VMKTYRQREK QGSKVQESTK
       130        140        150        160        170        180
GPDEAKIKAL LERTGYTLDV TTGQRKYGGP PPDSVYSGVQ PGIGTEVFVG KIPRDLYEDE
       190        200        210        220        230        240
LVPLFEKAGP IWDLRLMMDP LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC
       250        260        270        280        290        300
ISVANNRLFV GSIPKNKTKE NILEEFSKVT EGLVDVILYH QPDDKKKNRG FCFLEYEDHK
       310        320        330        340        350        360
SAAQARRRLM SGKVKVWGNV VTVEWADPVE EPDPEVMAKV KVLFVRNLAT TVTEEILEKS
       370        380        390        400        410        420
FSEFGKLERV KKLKDYAFVH FEDRGAAVKA MDEMNGKEIE GEEIEIVLAK PPDKKRKERQ
       430        440        450        460        470        480
AARQASRSTA YEDYYYHPPP RMPPPIRGRG RGGGRGGYGY PPDYYGYEDY YDDYYGYDYH
       490        500        510        520        530        540
DYRGGYEDPY YGYDDGYAVR GRGGGRGGRG APPPPRGRGA PPPRGRAGYS QRGAPLGPPR
       550        560        570        580        590        600
GSRGGRGGPA QQQRGRGSRG SRGNRGGNVG GKRKADGYNQ PDSKRRQTNN QQNWGSQPIA
       610        620        630
QQPLQQGGDY SGNYGYNNDN QEFYQDTYGQ QWK         10         20         30         40         50         60
MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF QTGLVAYVDL
        70         80         90        100        110        120
DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG VMKTYRQREK QGSKVQESTK
       130        140        150        160        170        180
GPDEAKIKAL LERTGYTLDV TTGQRKYGGP PPDSVYSGVQ PGIGTEVFVG KIPRDLYEDE
       190        200        210        220        230        240
LVPLFEKAGP IWDLRLMMDP LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC
       250        260        270        280        290        300
ISVANNRLFV GSIPKNKTKE NILEEFSKVT EGLVDVILYH QPDDKKKNRG FCFLEYEDHK
       310        320        330        340        350        360
SAAQARRRLM SGKVKVWGNV VTVEWADPVE EPDPEVMAKV KVLFVRNLAT TVTEEILEKS
       370        380        390        400        410        420
FSEFGKLERV KKLKDYAFVH FEDRGAAVKA MDEMNGKEIE GEEIEIVLAK PPDKKRKERQ
       430        440        450        460        470        480
AARQASRSTA YEDYYYHPPP RMPPPIRGRG RGGGRGGYGY PPDYYGYEDY YDDYYGYDYH
       490        500        510        520        530        540
DYRGGYEDPY YGYDDGYAVR GRGGGRGGRG APPPPRGRGA PPPRGRAGYS QRGAPLGPPR
       550        560        570        580        590        600
GSRGGRGGPA QQQRGRGSRG SRGNRGGNVG GKRKADGYNQ PDSKRRQTNN QQNWGSQPIA
       610        620        630
QQPLQQGGDY SGNYGYNNDN QEFYQDTYGQ QWK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

20 N-termini - 13 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43390-2-unknown	MANQVN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43390-1-unknown	MANQVN...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77187
O43390-1-unknown	MANQVN...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77188
O43390-2-Acetylation	ANQVNG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43390-2-Acetylation	ANQVNG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O43390-2-Acetylation	ANQVNG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110812
O43390-2-Acetylation	ANQVNG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110813
O43390-7-	GNAVQL...	7			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43390-7-unknown	GNAVQL...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176226
O43390-7-unknown	GNAVQL...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176227
O43390-67-unknown	ALREFN...	67		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1403
O43390-67-unknown	ALREFN...	67		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140434
O43390-67-unknown	ALREFN...	67		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140435
O43390-88-unknown	LSHVQN...	88		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1406
O43390-88-unknown	LSHVQN...	88		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141719
O43390-88-unknown	LSHVQN...	88		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141720
O43390-102-unknown	MKTYRQ...	102		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77189
O43390-102-unknown	MKTYRQ...	102		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000474437
O43390-102-unknown	MKTYRQ...	102		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000475760
O43390-102-unknown	MKTYRQ...	102		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000415042
O43390-102-unknown	MKTYRQ...	102		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103434
O43390-102-unknown	MKTYRQ...	102		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103435
O43390-118-unknown	STKGPD...	118		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18230
O43390-118-unknown	STKGPD...	118		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16879
O43390-118-unknown	STKGPD...	118		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136622
O43390-118-unknown	STKGPD...	118		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143356
O43390-124-unknown	EAKIKA...	124		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10741
O43390-124-unknown	EAKIKA...	124		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137096
O43390-124-unknown	EAKIKA...	124		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143682
O43390-167-unknown	VFVGKI...	167		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10744
O43390-167-unknown	VFVGKI...	167		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140401
O43390-167-unknown	VFVGKI...	167		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145434
O43390-167-unknown	VFVGKI...	167		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196425
O43390-293-unknown	FLEYED...	293		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3269
O43390-293-unknown	FLEYED...	293		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146440
O43390-293-unknown	FLEYED...	293		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148657
O43390-293-unknown	FLEYED...	293		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149774
O43390-350-unknown	TTVTEE...	350		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5155
O43390-350-unknown	TTVTEE...	350		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16883
O43390-350-unknown	TTVTEE...	350		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148468
O43390-350-unknown	TTVTEE...	350		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150148
O43390-350-unknown	TTVTEE...	350		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151003
O43390-378-unknown	FVHFED...	378		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5159
O43390-378-unknown	FVHFED...	378		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3273
O43390-378-unknown	FVHFED...	378		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149337
O43390-378-unknown	FVHFED...	378		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150723
O43390-378-unknown	FVHFED...	378		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151635
O43390-396-	GKEIEG...	396			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43390-396-unknown	GKEIEG...	396		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174410
O43390-396-unknown	GKEIEG...	396		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174411
O43390-396-unknown	GKEIEG...	396		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174412
O43390-402-unknown	EEIEIV...	402		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18234
O43390-402-unknown	EEIEIV...	402		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149970
O43390-402-unknown	EEIEIV...	402		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151270
O43390-402-unknown	EEIEIV...	402		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152065
O43390-403-unknown	EIEIVL...	403		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10747
O43390-403-unknown	EIEIVL...	403		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150014
O43390-403-unknown	EIEIVL...	403		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151315
O43390-403-unknown	EIEIVL...	403		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152092
O43390-473-unknown	DYYGYD...	473		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1409
O43390-473-unknown	DYYGYD...	473		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151509
O43390-473-unknown	DYYGYD...	473		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152554
O43390-473-unknown	DYYGYD...	473		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153147
O43390-482-unknown	YRGGYE...	482		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1413
O43390-482-unknown	YRGGYE...	482		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151717
O43390-482-unknown	YRGGYE...	482		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152699
O43390-482-unknown	YRGGYE...	482		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153250

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ERAIDA	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1403
...ERAIDA	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123560
...ERAIDA	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123561
...FKESDL	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1406
...FKESDL	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124901
...FKESDL	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124902
...SKVQES	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18230
...SKVQES	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16879
...SKVQES	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126587
...SKVQES	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126588
...TKGPDE	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10741
...TKGPDE	123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119962
...TKGPDE	123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126925
...TKGPDE	123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153687
...GIGTEV	166	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10744
...GIGTEV	166	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123524
...GIGTEV	166	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128727
...NRGFCF	292	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3269
...NRGFCF	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129745
...NRGFCF	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132032
...NRGFCF	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133165
...VRNLAT	349	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5155
...VRNLAT	349	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16883
...VRNLAT	349	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131841
...VRNLAT	349	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133541
...VRNLAT	349	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134406
...LKDYAF	377	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5159
...LKDYAF	377	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3273
...LKDYAF	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132722
...LKDYAF	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134121
...LKDYAF	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135039
...KEIEGE	401	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18234
...KEIEGE	401	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133362
...KEIEGE	401	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134672
...KEIEGE	401	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135475
...EIEGEE	402	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10747
...EIEGEE	402	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133406
...EIEGEE	402	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134717
...EIEGEE	402	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135501
...EDYYDD	472	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1409
...EDYYDD	472	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134913
...EDYYDD	472	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135968
...EDYYDD	472	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136573
...YDYHDY	481	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1413
...YDYHDY	481	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135121
...YDYHDY	481	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136119
...YDYHDY	481	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136675
...GQQWK	633	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GQQWK	633	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72807
...GQQWK	633	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72806
...GQQWK	633	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72805

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	66	AIDA.\|.ALRE	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
CASP3_HUMAN	87	ESDL.\|.LSHV	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
MEP1B_HUMAN	117	VQES.\|.STKG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	117	VQES.\|.STKG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	123	GPDE.\|.EAKI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	166	GTEV.\|.VFVG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATB_HUMAN	292	GFCF.\|.FLEY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	349	NLAT.\|.TTVT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	349	NLAT.\|.TTVT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	377	DYAF.\|.FVHF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	377	DYAF.\|.FVHF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	401	IEGE.\|.EEIE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	402	EGEE.\|.EIEI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP3_HUMAN	472	YYDD.\|.DYYG	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
CASP3_HUMAN	481	YHDY.\|.YRGG	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)