Q14847: LIM and SH3 domain protein 1
Protein names | - LIM and SH3 domain protein 1 - LASP-1 - Metastatic lymph node gene 50 protein - MLN 50 |
---|---|
Gene names | LASP1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q14847 |
33
N-termini
5
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ
70 80 90 100 110 120
SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI
130 140 150 160 170 180
KYHEEFEKSR MGPSGGEGME PERRDSQDGS SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA
190 200 210 220 230 240
QSYGGYKEPA APVSIQRSAP GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM
250 260
YGTVERTGDT GMLPANYVEA I
Isoforms
- Isoform 2 of LIM and SH3 domain protein 1 - Isoform 3 of LIM and SH3 domain protein 1Sequence View
10 20 30 40 50 60
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ
70 80 90 100 110 120
SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI
130 140 150 160 170 180
KYHEEFEKSR MGPSGGEGME PERRDSQDGS SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA
190 200 210 220 230 240
QSYGGYKEPA APVSIQRSAP GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM
250 260
YGTVERTGDT GMLPANYVEA I
10 20 30 40 50 60
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ
70 80 90 100 110 120
SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI
130 140 150 160 170 180
KYHEEFEKSR MGPSGGEGME PERRDSQDGS SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA
190 200 210 220 230 240
QSYGGYKEPA APVSIQRSAP GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM
250 260
YGTVERTGDT GMLPANYVEA I
Protein Neighborhood
Domains & Features
33 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q14847-1-Acetylation | MNPNCA... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q14847-1-Acetylation | MNPNCA... | 1 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
Q14847-1-Acetylation | MNPNCA... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt101381 | ||
Q14847-1-unknown | MNPNCA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt79398 | |||
Q14847-37-unknown | MTLNMK... | 37 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000391897 | |||
Q14847-37-unknown | MTLNMK... | 37 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164185 | |||
Q14847-37- | MTLNMK... | 37 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q14847-63-unknown | TMVADT... | 63 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q14847-63-unknown | TMVADT... | 63 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159874 | |||
Q14847-63- | TMVADT... | 63 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q14847-64-unknown | MVADTP... | 64 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175041 | |||
Q14847-64- | MVADTP... | 64 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q14847-64- | MVADTP... | 64 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q14847-74-unknown | LKQQSE... | 74 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q14847-74-unknown | LKQQSE... | 74 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159869 | |||
Q14847-74- | LKQQSE... | 74 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q14847-95- | GKGFSV... | 95 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q14847-95- | GKGFSV... | 95 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q14847-95- | GKGFSV... | 95 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q14847-95- | GKGFSV... | 95 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q14847-95-unknown | GKGFSV... | 95 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q14847-95-unknown | GKGFSV... | 95 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159866 | |||
Q14847-95-unknown | GKGFSV... | 95 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159867 | |||
Q14847-99-unknown | SVVADT... | 99 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q14847-99-unknown | SVVADT... | 99 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159871 | |||
Q14847-99-unknown | SVVADT... | 99 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159872 | |||
Q14847-99- | SVVADT... | 99 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q14847-99- | SVVADT... | 99 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q14847-115-unknown | DQISNI... | 115 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17944 | |||
Q14847-115-unknown | DQISNI... | 115 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19529 | |||
Q14847-115-unknown | DQISNI... | 115 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139792 | |||
Q14847-115-unknown | DQISNI... | 115 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143215 | |||
Q14847-119-unknown | NIKYHE... | 119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166345 | |||
Q14847-119-unknown | NIKYHE... | 119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166346 | |||
Q14847-119- | NIKYHE... | 119 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14847-119- | NIKYHE... | 119 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q14847-131-acetylation | MGPSGG... | 131 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
Q14847-131-acetylation | MGPSGG... | 131 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt183065 | ||
Q14847-131-acetylation | MGPSGG... | 131 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt183066 | ||
Q14847-144-unknown | RDSQDG... | 144 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000462564 | |||
Q14847-144-unknown | RDSQDG... | 144 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt197571 | |||
Q14847-144-unknown | RDSQDG... | 144 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt197572 | |||
Q14847-167-unknown | SAPVYQ... | 167 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14505 | |||
Q14847-167-unknown | SAPVYQ... | 167 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143013 | |||
Q14847-167-unknown | SAPVYQ... | 167 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145423 | |||
Q14847-167- | SAPVYQ... | 167 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14847-167- | SAPVYQ... | 167 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q14847-170-unknown | VYQQPQ... | 170 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166341 | |||
Q14847-170-unknown | VYQQPQ... | 170 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166342 | |||
Q14847-170- | VYQQPQ... | 170 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14847-170- | VYQQPQ... | 170 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q14847-170- | VYQQPQ... | 170 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q14847-179-unknown | VAQSYG... | 179 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166338 | |||
Q14847-179-unknown | VAQSYG... | 179 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166339 | |||
Q14847-179- | VAQSYG... | 179 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14847-179- | VAQSYG... | 179 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q14847-181- | QSYGGY... | 181 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14847-181-unknown | QSYGGY... | 181 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166348 | |||
Q14847-182- | SYGGYK... | 182 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q14847-182- | SYGGYK... | 182 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14847-182- | SYGGYK... | 182 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q14847-182- | SYGGYK... | 182 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q14847-182- | SYGGYK... | 182 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q14847-182- | SYGGYK... | 182 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q14847-182- | SYGGYK... | 182 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q14847-182-unknown | SYGGYK... | 182 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164180 | |||
Q14847-184-unknown | GGYKEP... | 184 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164182 | |||
Q14847-184- | GGYKEP... | 184 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q14847-184- | GGYKEP... | 184 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14847-184- | GGYKEP... | 184 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q14847-184- | GGYKEP... | 184 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q14847-184- | GGYKEP... | 184 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q14847-184- | GGYKEP... | 184 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q14847-184- | GGYKEP... | 184 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q14847-185-unknown | GYKEPA... | 185 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166350 | |||
Q14847-185- | GYKEPA... | 185 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14847-185- | GYKEPA... | 185 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q14847-185- | GYKEPA... | 185 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q14847-185- | GYKEPA... | 185 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q14847-185- | GYKEPA... | 185 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...IKKTQD | 114 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17944 | |||
...IKKTQD | 114 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19529 | |||
...IKKTQD | 114 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122891 | |||
...IKKTQD | 114 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126441 | |||
...HHIPTS | 166 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14505 | |||
...HHIPTS | 166 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126223 | |||
...HHIPTS | 166 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt128716 | |||
...SAPGGG | 202 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000391897 | |||
...SAPGGG | 202 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155657 | |||
...YVEAI | 261 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...YVEAI | 261 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt75017 | |||
...YVEAI | 261 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...YVEAI | 261 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MEP1A_HUMAN | 114 | KTQD.|.DQIS | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
MEP1B_HUMAN | 114 | KTQD.|.DQIS | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
GRAM_HUMAN | 166 | IPTS.|.SAPV | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|