P49591: Serine--tRNA ligase, cytoplasmic

General Information

Protein names	- Serine--tRNA ligase, cytoplasmic - 6.1.1.11 {ECO:0000269\|PubMed:22353712, ECO:0000269\|PubMed:24095058, ECO:0000269\|PubMed:26433229, ECO:0000269\|PubMed:28236339, ECO:0000269\|PubMed:9431993} - Seryl-tRNA synthetase - SerRS - Seryl-tRNA(Ser/Sec) synthetase
Gene names	SARS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49591

9 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVLDLDLFRV DKGGDPALIR ETQEKRFKDP GLVDQLVKAD SEWRRCRFRA DNLNKLKNLC
        70         80         90        100        110        120
SKTIGEKMKK KEPVGDDESV PENVLSFDDL TADALANLKV SQIKKVRLLI DEAILKCDAE
       130        140        150        160        170        180
RIKLEAERFE NLREIGNLLH PSVPISNDED VDNKVERIWG DCTVRKKYSH VDLVVMVDGF
       190        200        210        220        230        240
EGEKGAVVAG SRGYFLKGVL VFLEQALIQY ALRTLGSRGY IPIYTPFFMR KEVMQEVAQL
       250        260        270        280        290        300
SQFDEELYKV IGKGSEKSDD NSYDEKYLIA TSEQPIAALH RDEWLRPEDL PIKYAGLSTC
       310        320        330        340        350        360
FRQEVGSHGR DTRGIFRVHQ FEKIEQFVYS SPHDNKSWEM FEEMITTAEE FYQSLGIPYH
       370        380        390        400        410        420
IVNIVSGSLN HAASKKLDLE AWFPGSGAFR ELVSCSNCTD YQARRLRIRY GQTKKMMDKV
       430        440        450        460        470        480
EFVHMLNATM CATTRTICAI LENYQTEKGI TVPEKLKEFM PPGLQELIPF VKPAPIEQEP
       490        500        510
SKKQKKQHEG SKKKAAARDV TLENRLQNME VTDA

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49591-1-Acetylation	MVLDLD...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49591-1-Acetylation	MVLDLD...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49591-1-Acetylation	MVLDLD...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P49591-1-	MVLDLD...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49591-2-unknown	VLDLDL...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49591-2-unknown	VLDLDL...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P49591-2-	VLDLDL...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49591-2-	VLDLDL...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49591-2-	VLDLDL...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49591-2-	VLDLDL...	2			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P49591-2-	VLDLDL...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49591-29-unknown	DPGLVD...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17679
P49591-88-unknown	DDLTAD...	88		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17680
P49591-88-unknown	DDLTAD...	88		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19164
P49591-94-unknown	ALANLK...	94		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11590
P49591-142-	SVPISN...	142			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49591-149-unknown	EDVDNK...	149		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11591

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EKRFKD	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17679
...NVLSFD	87	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17680
...NVLSFD	87	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19164
...DLTADA	93	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11590
...PISNDE	148	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11591
...MEVTDA	513	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1884
...EVTDA	514	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EVTDA	514		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EVTDA	514		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...EVTDA	514		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EVTDA	514		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	28	RFKD.\|.DPGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	87	LSFD.\|.DDLT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	87	LSFD.\|.DDLT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	93	TADA.\|.ALAN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	148	SNDE.\|.EDVD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP3_HUMAN	513	VTDA.\|.A	inferred from experiment	unknown	MEROPS	Esquerda JE	Casas C et al.:Antibodies against c-Jun N-term... (C14.003)	11331419,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)