P68036: Ubiquitin-conjugating enzyme E2 L3

General Information

Protein names	- Ubiquitin-conjugating enzyme E2 L3 - 2.3.2.23 {ECO:0000269\|PubMed:20061386} - E2 ubiquitin-conjugating enzyme L3 - L-UBC - UbcH7 - Ubiquitin carrier protein L3 - Ubiquitin-conjugating enzyme E2-F1 - Ubiquitin-protein ligase L3
Gene names	UBE2L3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P68036

5 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ubiquitin-conjugating enzyme E2 L3 - Isoform 3 of Ubiquitin-conjugating enzyme E2 L3

Sequence View

        10         20         30         40         50         60
MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE
        70         80         90        100        110        120
YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP
       130        140        150
LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD         10         20         30         40         50         60
MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE
        70         80         90        100        110        120
YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP
       130        140        150
LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P68036-1-unknown	MAASRR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P68036-37-unknown	GLIVPD...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6155
P68036-37-unknown	GLIVPD...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142103
P68036-87-unknown	LPVISA...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3909
P68036-87-unknown	LPVISA...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19287
P68036-87-unknown	LPVISA...	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139520
P68036-87-unknown	LPVISA...	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144522
P68036-87-unknown	LPVISA...	87	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P68036-87-unknown	LPVISA...	87	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P68036-91-unknown	SAENWK...	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7672
P68036-91-unknown	SAENWK...	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139862
P68036-91-unknown	SAENWK...	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144704
P68036-92-unknown	AENWKP...	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17806
P68036-92-unknown	AENWKP...	92	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139926
P68036-92-unknown	AENWKP...	92	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144731

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LLTWQG	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6155
...LLTWQG	36	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt125288
...KGQVCL	86	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3909
...KGQVCL	86	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19287
...KGQVCL	86	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122610
...KGQVCL	86	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127789
...CLPVIS	90	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7672
...CLPVIS	90	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122962
...CLPVIS	90	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127972
...LPVISA	91	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17806
...LPVISA	91	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt123031
...LPVISA	91	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt128006
...KRPVD	154	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KRPVD	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt89170
...KRPVD	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt89171
...KRPVD	154		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	36	TWQG.\|.GLIV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	86	QVCL.\|.LPVI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	86	QVCL.\|.LPVI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	90	PVIS.\|.SAEN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	91	VISA.\|.AENW	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)