Q06323: Proteasome activator complex subunit 1

General Information

Protein names	- Proteasome activator complex subunit 1 - 11S regulator complex subunit alpha - REG-alpha - Activator of multicatalytic protease subunit 1 - Interferon gamma up-regulated I-5111 protein - IGUP I-5111 - Proteasome activator 28 subunit alpha - PA28a - PA28alpha
Gene names	PSME1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q06323

6 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Proteasome activator complex subunit 1 - Isoform 3 of Proteasome activator complex subunit 1

Sequence View

        10         20         30         40         50         60
MAMLRVQPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP
        70         80         90        100        110        120
LDIPVPDPVK EKEKEERKKQ QEKEDKDEKK KGEDEDKGPP CGPVNCNEKI VVLLQRLKPE
       130        140        150        160        170        180
IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TSLHTKLEGF HTQISKYFSE
       190        200        210        220        230        240
RGDAVTKAAK QPHVGDYRQL VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP

RGETKGMIY         10         20         30         40         50         60
MAMLRVQPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP
        70         80         90        100        110        120
LDIPVPDPVK EKEKEERKKQ QEKEDKDEKK KGEDEDKGPP CGPVNCNEKI VVLLQRLKPE
       130        140        150        160        170        180
IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TSLHTKLEGF HTQISKYFSE
       190        200        210        220        230        240
RGDAVTKAAK QPHVGDYRQL VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP

RGETKGMIY

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q06323-1-unknown	MAMLRV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q06323-1-unknown	MAMLRV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86402
Q06323-6-unknown	VQPEAQ...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17856
Q06323-6-unknown	VQPEAQ...	6		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194735
Q06323-42-	AFLKEP...	42			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q06323-42-unknown	AFLKEP...	42		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176172
Q06323-94-unknown	DEDKGP...	94		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19355
Q06323-94-unknown	DEDKGP...	94		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142084
Q06323-159-acetylation	LMTSLH...	159	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q06323-159-acetylation	LMTSLH...	159	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183014

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MAMLRV	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17856
...KKKGED	93	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19355
...KKKGED	93	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt125269
...KGMIY	249		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KGMIY	249		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KGMIY	249	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KGMIY	249		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KGMIY	249		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	5	MLRV.\|.VQPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	93	KGED.\|.DEDK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)