P51991: Heterogeneous nuclear ribonucleoprotein A3

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein A3 - hnRNP A3
Gene names	HNRNPA3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P51991

26 N-termini

10 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS LREHFEKWGT
        70         80         90        100        110        120
LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV DGRVVEPKRA VSREDSVKPG
       130        140        150        160        170        180
AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG KIETIEVMED RQSGKKRGFA FVTFDDHDTV
       190        200        210        220        230        240
DKIVVQKYHT INGHNCEVKK ALSKQEMQSA GSQRGRGGGS GNFMGRGGNF GGGGGNFGRG
       250        260        270        280        290        300
GNFGGRGGYG GGGGGSRGSY GGGDGGYNGF GGDGGNYGGG PGYSSRGGYG GGGPGYGNQG
       310        320        330        340        350        360
GGYGGGGGYD GYNEGGNFGG GNYGGGGNYN DFGNYSGQQQ SNYGPMKGGS FGGRSSGSPY
       370
GGGYGSGGGS GGYGSRRF

Isoforms

- Isoform 2 of Heterogeneous nuclear ribonucleoprotein A3

Sequence View

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Protein Neighborhood

Domains & Features

26 N-termini - 10 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P51991-1-unknown	MEVKPP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P51991-1-acetylation	MEVKPP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P51991-1-acetylation	MEVKPP...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P51991-1-	MEVKPP...	1			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P51991-27-unknown	DPKEPE...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17706
P51991-27-unknown	DPKEPE...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19182
P51991-27-unknown	DPKEPE...	27		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195452
P51991-40-unknown	GGLSFE...	40		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5975
P51991-40-unknown	GGLSFE...	40		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136708
P51991-41-unknown	GLSFET...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5977
P51991-41-unknown	GLSFET...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3822
P51991-41-unknown	GLSFET...	41		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136782
P51991-42-unknown	LSFETT...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3824
P51991-42-unknown	LSFETT...	42		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136883
P51991-110-unknown	AVSRED...	110		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167388
P51991-110-	AVSRED...	110			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P51991-110-	AVSRED...	110			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P51991-110-	AVSRED...	110			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P51991-116-unknown	SVKPGA...	116			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P51991-116-unknown	SVKPGA...	116		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162029
P51991-116-	SVKPGA...	116			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P51991-116-	SVKPGA...	116			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P51991-116-	SVKPGA...	116			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P51991-116-	SVKPGA...	116			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P51991-116-	SVKPGA...	116			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P51991-116-	SVKPGA...	116			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P51991-132-unknown	GIKEDT...	132		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5979
P51991-132-unknown	GIKEDT...	132		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142936
P51991-144-unknown	DYFEKY...	144		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17707
P51991-144-unknown	DYFEKY...	144		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19183
P51991-144-unknown	DYFEKY...	144		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143555
P51991-146-unknown	FEKYGK...	146		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17709
P51991-146-unknown	FEKYGK...	146		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143643
P51991-150-unknown	GKIETI...	150		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174032
P51991-150-	GKIETI...	150			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P51991-150-	GKIETI...	150			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P51991-150-	GKIETI...	150			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P51991-168-	GFAFVT...	168			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P51991-168-	GFAFVT...	168			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P51991-168-	GFAFVT...	168			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P51991-168-	GFAFVT...	168			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P51991-168-	GFAFVT...	168			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P51991-168-unknown	GFAFVT...	168		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171137
P51991-179-	TVDKIV...	179			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P51991-179-unknown	TVDKIV...	179			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P51991-179-unknown	TVDKIV...	179		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162031
P51991-274-unknown	GGNYGG...	274		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11648
P51991-274-unknown	GGNYGG...	274		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148494
P51991-341-unknown	SNYGPM...	341		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176737
P51991-341-	SNYGPM...	341			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P51991-342-unknown	NYGPMK...	342		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176739
P51991-342-	NYGPMK...	342			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P51991-366-unknown	SGGGSG...	366		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17711
P51991-366-unknown	SGGGSG...	366		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150816

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GEEGHD	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17706
...GEEGHD	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19182
...RKLFIG	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5975
...KLFIGG	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5977
...KLFIGG	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3822
...LFIGGL	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3824
...KIFVGG	131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5979
...KIFVGG	131	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126146
...EYNLRD	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17707
...EYNLRD	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19183
...EYNLRD	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126795
...NLRDYF	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17709
...NLRDYF	145	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126885
...GFGGDG	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11648
...GFGGDG	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131867
...GGGYGS	365	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17711
...GGGYGS	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134218
...GSRRF	378	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GSRRF	378	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83672

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	26	EGHD.\|.DPKE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	26	EGHD.\|.DPKE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	39	LFIG.\|.GGLS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	40	FIGG.\|.GLSF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	40	FIGG.\|.GLSF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	41	IGGL.\|.LSFE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	131	FVGG.\|.GIKE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	143	NLRD.\|.DYFE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	143	NLRD.\|.DYFE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	145	RDYF.\|.FEKY	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	273	GGDG.\|.GGNY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1A_HUMAN	365	GYGS.\|.SGGG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)