Q99757: Thioredoxin, mitochondrial

General Information

Protein names	- Thioredoxin, mitochondrial - MTRX - Mt-Trx - Thioredoxin-2
Gene names	TXN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99757

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQRLLLRRF LASVISRKPS QGQWPPLTSR ALQTPQCSPG GLTVTPNPAR TIYTTRISLT
        70         80         90        100        110        120
TFNIQDGPDF QDRVVNSETP VVVDFHAQWC GPCKILGPRL EKMVAKQHGK VVMAKVDIDD
       130        140        150        160
HTDLAIEYEV SAVPTVLAMK NGDVVDKFVG IKDEDQLEAF LKKLIG

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99757-60-	TTFNIQ...	60		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q99757-60-	TTFNIQ...	60		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99757-60-	TTFNIQ...	60		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q99757-60-	TTFNIQ...	60		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q99757-60-	TTFNIQ...	60		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q99757-60-	TTFNIQ...	60		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q99757-60-unknown	TTFNIQ...	60	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99757-62-	FNIQDG...	62		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99757-63-	NIQDGP...	63		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99757-103-unknown	MVAKQH...	103	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000469160
Q99757-143-unknown	DVVDKF...	143	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19753

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...AMKNGD	142	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19753
	...KKLIG	166	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	142	KNGD.\|.DVVD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)