Q9BRK5: 45 kDa calcium-binding protein

General Information

Protein names	- 45 kDa calcium-binding protein - Cab45 - Stromal cell-derived factor 4 - SDF-4
Gene names	SDF4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BRK5

11 N-termini

8 C-termini

10 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of 45 kDa calcium-binding protein - Isoform 3 of 45 kDa calcium-binding protein - Isoform 4 of 45 kDa calcium-binding protein - Isoform 5 of 45 kDa calcium-binding protein - Isoform 6 of 45 kDa calcium-binding protein

Sequence View

        10         20         30         40         50         60
MVWPWVAMAS RWGPLIGLAP CCLWLLGAVL LMDASARPAN HSSTRERVAN REENEILPPD
        70         80         90        100        110        120
HLNGVKLEMD GHLNRGFHQE VFLGKDLGGF DEDAEPRRSR RKLMVIFSKV DVNTDRKISA
       130        140        150        160        170        180
KEMQRWIMEK TAEHFQEAME ESKTHFRAVD PDGDGHVSWD EYKVKFLASK GHSEKEVADA
       190        200        210        220        230        240
IRLNEELKVD EETQEVLENL KDRWYQADSP PADLLLTEEE FLSFLHPEHS RGMLRFMVKE
       250        260        270        280        290        300
IVRDLDQDGD KQLSVPEFIS LPVGTVENQQ GQDIDDNWVK DRKKEFEELI DSNHDGIVTA
       310        320        330        340        350        360
EELESYMDPM NEYNALNEAK QMIAVADENQ NHHLEPEEVL KYSEFFTGSK LVDYARSVHE

EF         10         20         30         40         50         60
MVWPWVAMAS RWGPLIGLAP CCLWLLGAVL LMDASARPAN HSSTRERVAN REENEILPPD
        70         80         90        100        110        120
HLNGVKLEMD GHLNRGFHQE VFLGKDLGGF DEDAEPRRSR RKLMVIFSKV DVNTDRKISA
       130        140        150        160        170        180
KEMQRWIMEK TAEHFQEAME ESKTHFRAVD PDGDGHVSWD EYKVKFLASK GHSEKEVADA
       190        200        210        220        230        240
IRLNEELKVD EETQEVLENL KDRWYQADSP PADLLLTEEE FLSFLHPEHS RGMLRFMVKE
       250        260        270        280        290        300
IVRDLDQDGD KQLSVPEFIS LPVGTVENQQ GQDIDDNWVK DRKKEFEELI DSNHDGIVTA
       310        320        330        340        350        360
EELESYMDPM NEYNALNEAK QMIAVADENQ NHHLEPEEVL KYSEFFTGSK LVDYARSVHE

EF         10         20         30         40         50         60
MVWPWVAMAS RWGPLIGLAP CCLWLLGAVL LMDASARPAN HSSTRERVAN REENEILPPD
        70         80         90        100        110        120
HLNGVKLEMD GHLNRGFHQE VFLGKDLGGF DEDAEPRRSR RKLMVIFSKV DVNTDRKISA
       130        140        150        160        170        180
KEMQRWIMEK TAEHFQEAME ESKTHFRAVD PDGDGHVSWD EYKVKFLASK GHSEKEVADA
       190        200        210        220        230        240
IRLNEELKVD EETQEVLENL KDRWYQADSP PADLLLTEEE FLSFLHPEHS RGMLRFMVKE
       250        260        270        280        290        300
IVRDLDQDGD KQLSVPEFIS LPVGTVENQQ GQDIDDNWVK DRKKEFEELI DSNHDGIVTA
       310        320        330        340        350        360
EELESYMDPM NEYNALNEAK QMIAVADENQ NHHLEPEEVL KYSEFFTGSK LVDYARSVHE

EF         10         20         30         40         50         60
MVWPWVAMAS RWGPLIGLAP CCLWLLGAVL LMDASARPAN HSSTRERVAN REENEILPPD
        70         80         90        100        110        120
HLNGVKLEMD GHLNRGFHQE VFLGKDLGGF DEDAEPRRSR RKLMVIFSKV DVNTDRKISA
       130        140        150        160        170        180
KEMQRWIMEK TAEHFQEAME ESKTHFRAVD PDGDGHVSWD EYKVKFLASK GHSEKEVADA
       190        200        210        220        230        240
IRLNEELKVD EETQEVLENL KDRWYQADSP PADLLLTEEE FLSFLHPEHS RGMLRFMVKE
       250        260        270        280        290        300
IVRDLDQDGD KQLSVPEFIS LPVGTVENQQ GQDIDDNWVK DRKKEFEELI DSNHDGIVTA
       310        320        330        340        350        360
EELESYMDPM NEYNALNEAK QMIAVADENQ NHHLEPEEVL KYSEFFTGSK LVDYARSVHE

EF         10         20         30         40         50         60
MVWPWVAMAS RWGPLIGLAP CCLWLLGAVL LMDASARPAN HSSTRERVAN REENEILPPD
        70         80         90        100        110        120
HLNGVKLEMD GHLNRGFHQE VFLGKDLGGF DEDAEPRRSR RKLMVIFSKV DVNTDRKISA
       130        140        150        160        170        180
KEMQRWIMEK TAEHFQEAME ESKTHFRAVD PDGDGHVSWD EYKVKFLASK GHSEKEVADA
       190        200        210        220        230        240
IRLNEELKVD EETQEVLENL KDRWYQADSP PADLLLTEEE FLSFLHPEHS RGMLRFMVKE
       250        260        270        280        290        300
IVRDLDQDGD KQLSVPEFIS LPVGTVENQQ GQDIDDNWVK DRKKEFEELI DSNHDGIVTA
       310        320        330        340        350        360
EELESYMDPM NEYNALNEAK QMIAVADENQ NHHLEPEEVL KYSEFFTGSK LVDYARSVHE

EF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 8 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9BRK5-1-unknown	MVWPWV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68955
Q9BRK5-1-unknown	MVWPWV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68956
Q9BRK5-1-unknown	MVWPWV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68958
Q9BRK5-37-unknown	RPANHS...	37	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9BRK5-37-unknown	RPANHS...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115325
Q9BRK5-37-unknown	RPANHS...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115326
Q9BRK5-37-unknown	RPANHS...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115327
Q9BRK5-81-unknown	VFLGKD...	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18097
Q9BRK5-81-unknown	VFLGKD...	81	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141386
Q9BRK5-81-unknown	VFLGKD...	81	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141387
Q9BRK5-81-unknown	VFLGKD...	81	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141388
Q9BRK5-104-unknown	MVIFSK...	104	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68954
Q9BRK5-104-unknown	MVIFSK...	104	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100981
Q9BRK5-104-unknown	MVIFSK...	104	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100982
Q9BRK5-104-unknown	MVIFSK...	104	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100983
Q9BRK5-137-unknown	EAMEES...	137	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19761
Q9BRK5-137-unknown	EAMEES...	137	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18101
Q9BRK5-137-unknown	EAMEES...	137	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137858
Q9BRK5-137-unknown	EAMEES...	137	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144163
Q9BRK5-137-unknown	EAMEES...	137	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144165
Q9BRK5-137-unknown	EAMEES...	137	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144167
Q9BRK5-169-unknown	SKGHSE...	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19766
Q9BRK5-169-unknown	SKGHSE...	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18106
Q9BRK5-169-unknown	SKGHSE...	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140343
Q9BRK5-169-unknown	SKGHSE...	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145486
Q9BRK5-169-unknown	SKGHSE...	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145487
Q9BRK5-169-unknown	SKGHSE...	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145489
Q9BRK5-185-unknown	EELKVD...	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19771
Q9BRK5-185-unknown	EELKVD...	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18111
Q9BRK5-185-unknown	EELKVD...	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141411
Q9BRK5-185-unknown	EELKVD...	185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146058
Q9BRK5-213-unknown	DLLLTE...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18114
Q9BRK5-213-unknown	DLLLTE...	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142958
Q9BRK5-213-unknown	DLLLTE...	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147114
Q9BRK5-233-unknown	MLRFMV...	233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68957
Q9BRK5-233-unknown	MLRFMV...	233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101142
Q9BRK5-233-unknown	MLRFMV...	233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101141
Q9BRK5-273-unknown	DIDDNW...	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19774
Q9BRK5-273-unknown	DIDDNW...	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138406
Q9BRK5-273-unknown	DIDDNW...	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145527
Q9BRK5-273-unknown	DIDDNW...	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149188
Q9BRK5-294-unknown	HDGIVT...	294	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13182
Q9BRK5-294-unknown	HDGIVT...	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140092
Q9BRK5-294-unknown	HDGIVT...	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146282

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GFHQEV	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18097
...GFHQEV	80	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124555
...GFHQEV	80	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124556
...GFHQEV	80	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124557
...AEHFQE	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19761
...AEHFQE	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18101
...AEHFQE	136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120863
...AEHFQE	136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127416
...AEHFQE	136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127418
...AEHFQE	136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127420
...VKFLAS	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19766
...VKFLAS	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18106
...VKFLAS	168	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123465
...VKFLAS	168	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128782
...VKFLAS	168	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128783
...VKFLAS	168	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128785
...AIRLNE	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19771
...AIRLNE	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18111
...AIRLNE	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124582
...AIRLNE	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129357
...AIRLNE	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154137
...AIRLNE	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154138
...DSPPAD	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18114
...DSPPAD	212	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126170
...DSPPAD	212	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130448
...NQQGQD	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19774
...NQQGQD	272	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121447
...NQQGQD	272	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128824
...NQQGQD	272	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132573
...LIDSNH	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13182
...LIDSNH	293	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123200
...LIDSNH	293	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129587
...LIDSNH	293	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133094
...VHEEF	362	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VHEEF	362	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64575
...VHEEF	362	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64572

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	80	HQEV.\|.VFLG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	136	HFQE.\|.EAME	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	136	HFQE.\|.EAME	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	168	FLAS.\|.SKGH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	168	FLAS.\|.SKGH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	184	RLNE.\|.EELK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	184	RLNE.\|.EELK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	212	PPAD.\|.DLLL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	272	QGQD.\|.DIDD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	293	DSNH.\|.HDGI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)