P04083: Annexin A1

General Information

Protein names	- Annexin A1 - Annexin I - Annexin-1 - Calpactin II - Calpactin-2 - Chromobindin-9 - Lipocortin I {ECO:0000303\|PubMed:1832554} - Phospholipase A2 inhibitory protein - p35
Gene names	ANXA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04083

7 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA LHKAIMVKGV
        70         80         90        100        110        120
DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL TGHLEEVVLA LLKTPAQFDA
       130        140        150        160        170        180
DELRAAMKGL GTDEDTLIEI LASRTNKEIR DINRVYREEL KRDLAKDITS DTSGDFRNAL
       190        200        210        220        230        240
LSLAKGDRSE DFGVNEDLAD SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY
       250        260        270        280        290        300
TKYSKHDMNK VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM
       310        320        330        340
VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04083-2-unknown	MAMVSE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04083-2-Acetylation	AMVSEF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04083-57-unknown	VKGVDE...	57		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17086
P04083-62-unknown	EATIID...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17087
P04083-62-unknown	EATIID...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18427
P04083-127-unknown	MKGLGT...	127		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17088
P04083-127-unknown	MKGLGT...	127		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18428
P04083-136-acetylation	TLIEIL...	136	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P04083-214-	KGTDVN...	214			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HKAIMV	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17086
...VKGVDE	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17087
...VKGVDE	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18427
...LLKTPA	115	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414013
...ELRAAM	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17088
...ELRAAM	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18428
...SEDFGV	193	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412489
...LCGGN	346	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	56	AIMV.\|.VKGV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	61	GVDE.\|.EATI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	61	GVDE.\|.EATI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	126	RAAM.\|.MKGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	126	RAAM.\|.MKGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)