P05023: Sodium/potassium-transporting ATPase subunit alpha-1

General Information

Protein names	- Sodium/potassium-transporting ATPase subunit alpha-1 - Na(+)/K(+) ATPase alpha-1 subunit - 7.2.2.13 - Sodium pump subunit alpha-1
Gene names	ATP1A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05023

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGKGVGRDKY EPAAVSEQGD KKGKKGKKDR DMDELKKEVS MDDHKLSLDE LHRKYGTDLS
        70         80         90        100        110        120
RGLTSARAAE ILARDGPNAL TPPPTTPEWI KFCRQLFGGF SMLLWIGAIL CFLAYSIQAA
       130        140        150        160        170        180
TEEEPQNDNL YLGVVLSAVV IITGCFSYYQ EAKSSKIMES FKNMVPQQAL VIRNGEKMSI
       190        200        210        220        230        240
NAEEVVVGDL VEVKGGDRIP ADLRIISANG CKVDNSSLTG ESEPQTRSPD FTNENPLETR
       250        260        270        280        290        300
NIAFFSTNCV EGTARGIVVY TGDRTVMGRI ATLASGLEGG QTPIAAEIEH FIHIITGVAV
       310        320        330        340        350        360
FLGVSFFILS LILEYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN
       370        380        390        400        410        420
LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTENQSGVS FDKTSATWLA
       430        440        450        460        470        480
LSRIAGLCNR AVFQANQENL PILKRAVAGD ASESALLKCI ELCCGSVKEM RERYAKIVEI
       490        500        510        520        530        540
PFNSTNKYQL SIHKNPNTSE PQHLLVMKGA PERILDRCSS ILLHGKEQPL DEELKDAFQN
       550        560        570        580        590        600
AYLELGGLGE RVLGFCHLFL PDEQFPEGFQ FDTDDVNFPI DNLCFVGLIS MIDPPRAAVP
       610        620        630        640        650        660
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVSQVNPRDA
       670        680        690        700        710        720
KACVVHGSDL KDMTSEQLDD ILKYHTEIVF ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN
       730        740        750        760        770        780
DSPALKKADI GVAMGIAGSD VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL
       790        800        810        820        830        840
TSNIPEITPF LIFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK
       850        860        870        880        890        900
TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP IHLLGLRVDW DDRWINDVED
       910        920        930        940        950        960
SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK NKILIFGLFE
       970        980        990       1000       1010       1020
ETALAAFLSY CPGMGVALRM YPLKPTWWFC AFPYSLLIFV YDEVRKLIIR RRPGGWVEKE

TYY

Isoforms

- Isoform 2 of Sodium/potassium-transporting ATPase subunit alpha-1 - Isoform 3 of Sodium/potassium-transporting ATPase subunit alpha-1 - Isoform 4 of Sodium/potassium-transporting ATPase subunit alpha-1

Sequence View

        10         20         30         40         50         60
MGKGVGRDKY EPAAVSEQGD KKGKKGKKDR DMDELKKEVS MDDHKLSLDE LHRKYGTDLS
        70         80         90        100        110        120
RGLTSARAAE ILARDGPNAL TPPPTTPEWI KFCRQLFGGF SMLLWIGAIL CFLAYSIQAA
       130        140        150        160        170        180
TEEEPQNDNL YLGVVLSAVV IITGCFSYYQ EAKSSKIMES FKNMVPQQAL VIRNGEKMSI
       190        200        210        220        230        240
NAEEVVVGDL VEVKGGDRIP ADLRIISANG CKVDNSSLTG ESEPQTRSPD FTNENPLETR
       250        260        270        280        290        300
NIAFFSTNCV EGTARGIVVY TGDRTVMGRI ATLASGLEGG QTPIAAEIEH FIHIITGVAV
       310        320        330        340        350        360
FLGVSFFILS LILEYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN
       370        380        390        400        410        420
LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTENQSGVS FDKTSATWLA
       430        440        450        460        470        480
LSRIAGLCNR AVFQANQENL PILKRAVAGD ASESALLKCI ELCCGSVKEM RERYAKIVEI
       490        500        510        520        530        540
PFNSTNKYQL SIHKNPNTSE PQHLLVMKGA PERILDRCSS ILLHGKEQPL DEELKDAFQN
       550        560        570        580        590        600
AYLELGGLGE RVLGFCHLFL PDEQFPEGFQ FDTDDVNFPI DNLCFVGLIS MIDPPRAAVP
       610        620        630        640        650        660
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVSQVNPRDA
       670        680        690        700        710        720
KACVVHGSDL KDMTSEQLDD ILKYHTEIVF ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN
       730        740        750        760        770        780
DSPALKKADI GVAMGIAGSD VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL
       790        800        810        820        830        840
TSNIPEITPF LIFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK
       850        860        870        880        890        900
TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP IHLLGLRVDW DDRWINDVED
       910        920        930        940        950        960
SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK NKILIFGLFE
       970        980        990       1000       1010       1020
ETALAAFLSY CPGMGVALRM YPLKPTWWFC AFPYSLLIFV YDEVRKLIIR RRPGGWVEKE

TYY         10         20         30         40         50         60
MGKGVGRDKY EPAAVSEQGD KKGKKGKKDR DMDELKKEVS MDDHKLSLDE LHRKYGTDLS
        70         80         90        100        110        120
RGLTSARAAE ILARDGPNAL TPPPTTPEWI KFCRQLFGGF SMLLWIGAIL CFLAYSIQAA
       130        140        150        160        170        180
TEEEPQNDNL YLGVVLSAVV IITGCFSYYQ EAKSSKIMES FKNMVPQQAL VIRNGEKMSI
       190        200        210        220        230        240
NAEEVVVGDL VEVKGGDRIP ADLRIISANG CKVDNSSLTG ESEPQTRSPD FTNENPLETR
       250        260        270        280        290        300
NIAFFSTNCV EGTARGIVVY TGDRTVMGRI ATLASGLEGG QTPIAAEIEH FIHIITGVAV
       310        320        330        340        350        360
FLGVSFFILS LILEYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN
       370        380        390        400        410        420
LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTENQSGVS FDKTSATWLA
       430        440        450        460        470        480
LSRIAGLCNR AVFQANQENL PILKRAVAGD ASESALLKCI ELCCGSVKEM RERYAKIVEI
       490        500        510        520        530        540
PFNSTNKYQL SIHKNPNTSE PQHLLVMKGA PERILDRCSS ILLHGKEQPL DEELKDAFQN
       550        560        570        580        590        600
AYLELGGLGE RVLGFCHLFL PDEQFPEGFQ FDTDDVNFPI DNLCFVGLIS MIDPPRAAVP
       610        620        630        640        650        660
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVSQVNPRDA
       670        680        690        700        710        720
KACVVHGSDL KDMTSEQLDD ILKYHTEIVF ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN
       730        740        750        760        770        780
DSPALKKADI GVAMGIAGSD VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL
       790        800        810        820        830        840
TSNIPEITPF LIFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK
       850        860        870        880        890        900
TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP IHLLGLRVDW DDRWINDVED
       910        920        930        940        950        960
SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK NKILIFGLFE
       970        980        990       1000       1010       1020
ETALAAFLSY CPGMGVALRM YPLKPTWWFC AFPYSLLIFV YDEVRKLIIR RRPGGWVEKE

TYY         10         20         30         40         50         60
MGKGVGRDKY EPAAVSEQGD KKGKKGKKDR DMDELKKEVS MDDHKLSLDE LHRKYGTDLS
        70         80         90        100        110        120
RGLTSARAAE ILARDGPNAL TPPPTTPEWI KFCRQLFGGF SMLLWIGAIL CFLAYSIQAA
       130        140        150        160        170        180
TEEEPQNDNL YLGVVLSAVV IITGCFSYYQ EAKSSKIMES FKNMVPQQAL VIRNGEKMSI
       190        200        210        220        230        240
NAEEVVVGDL VEVKGGDRIP ADLRIISANG CKVDNSSLTG ESEPQTRSPD FTNENPLETR
       250        260        270        280        290        300
NIAFFSTNCV EGTARGIVVY TGDRTVMGRI ATLASGLEGG QTPIAAEIEH FIHIITGVAV
       310        320        330        340        350        360
FLGVSFFILS LILEYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN
       370        380        390        400        410        420
LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTENQSGVS FDKTSATWLA
       430        440        450        460        470        480
LSRIAGLCNR AVFQANQENL PILKRAVAGD ASESALLKCI ELCCGSVKEM RERYAKIVEI
       490        500        510        520        530        540
PFNSTNKYQL SIHKNPNTSE PQHLLVMKGA PERILDRCSS ILLHGKEQPL DEELKDAFQN
       550        560        570        580        590        600
AYLELGGLGE RVLGFCHLFL PDEQFPEGFQ FDTDDVNFPI DNLCFVGLIS MIDPPRAAVP
       610        620        630        640        650        660
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVSQVNPRDA
       670        680        690        700        710        720
KACVVHGSDL KDMTSEQLDD ILKYHTEIVF ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN
       730        740        750        760        770        780
DSPALKKADI GVAMGIAGSD VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL
       790        800        810        820        830        840
TSNIPEITPF LIFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK
       850        860        870        880        890        900
TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP IHLLGLRVDW DDRWINDVED
       910        920        930        940        950        960
SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK NKILIFGLFE
       970        980        990       1000       1010       1020
ETALAAFLSY CPGMGVALRM YPLKPTWWFC AFPYSLLIFV YDEVRKLIIR RRPGGWVEKE

TYY

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05023-1-unknown	MGKGVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67734
P05023-6-unknown	GRDKYE...	6	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05023-6-unknown	GRDKYE...	6	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111757
P05023-6-unknown	GRDKYE...	6	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111758
P05023-32-unknown	MDELKK...	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67735
P05023-32-unknown	MDELKK...	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104384
P05023-32-unknown	MDELKK...	32	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104385
P05023-500-unknown	EPQHLL...	500	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18454
P05023-500-unknown	EPQHLL...	500	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153055
P05023-500-unknown	EPQHLL...	500	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153404
P05023-500-unknown	EPQHLL...	500	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153405

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NPNTSE	499	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18454
...NPNTSE	499	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136480
...NPNTSE	499	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136828
...NPNTSE	499	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136829
...KETYY	1023	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KETYY	1023	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63353
...KETYY	1023	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63354

TopFIND

P05023: Sodium/potassium-transporting ATPase subunit alpha-1

General Information

4

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates