P62269: 40S ribosomal protein S18

General Information

Protein names	- 40S ribosomal protein S18 - Ke-3 - Ke3 - Small ribosomal subunit protein uS13 {ECO:0000303\|PubMed:24524803}
Gene names	RPS18
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62269

9 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI DLTKRAGELT
        70         80         90        100        110        120
EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA NGLDNKLRED LERLKKIRAH
       130        140        150
RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK KK

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62269-2-unknown	MSLVIP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62269-2-Acetylation	SLVIPE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62269-2-Acetylation	SLVIPE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P62269-2-Acetylation	SLVIPE...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P62269-47-unknown	KADIDL...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10128
P62269-47-unknown	KADIDL...	47			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P62269-56-unknown	AGELTE...	56		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10129
P62269-71-unknown	MQNPRQ...	71		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434786
P62269-71-unknown	MQNPRQ...	71		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431721
P62269-71-unknown	MQNPRQ...	71		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434837
P62269-71-unknown	MQNPRQ...	71		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432580
P62269-71-unknown	MQNPRQ...	71		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000437050
P62269-71-unknown	MQNPRQ...	71		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431986
P62269-78-unknown	KIPDWF...	78		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19260
P62269-92-	DGKYSQ...	92			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62269-96-	SQVLAN...	96			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62269-96-	SQVLAN...	96			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P62269-96-unknown	SQVLAN...	96			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...HVVLRK	46	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10128
...DLTKRA	55	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10129
...NPRQYK	77	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19260
...VSKKK	152	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VSKKK	152		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VSKKK	152		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...VSKKK	152		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VSKKK	152		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	46	VLRK.\|.KADI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	55	TKRA.\|.AGEL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1B_HUMAN	77	RQYK.\|.KIPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)