Q86U42: Polyadenylate-binding protein 2

General Information

Protein names	- Polyadenylate-binding protein 2 - PABP-2 - Poly(A)-binding protein 2 - Nuclear poly(A)-binding protein 1 - Poly(A)-binding protein II - PABII - Polyadenylate-binding nuclear protein 1
Gene names	PABPN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86U42

18 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAAAAAAA AGAAGGRGSG PGRRRHLVPG AGGEAGEGAP GGAGDYGNGL ESEELEPEEL
        70         80         90        100        110        120
LLEPEPEPEP EEEPPRPRAP PGAPGPGPGS GAPGSQEEEE EPGLVEGDPG DGAIEDPELE
       130        140        150        160        170        180
AIKARVREME EEAEKLKELQ NEVEKQMNMS PPPGNAGPVI MSIEEKMEAD ARSIYVGNVD
       190        200        210        220        230        240
YGATAEELEA HFHGCGSVNR VTILCDKFSG HPKGFAYIEF SDKESVRTSL ALDESLFRGR
       250        260        270        280        290        300
QIKVIPKRTN RPGISTTDRG FPRARYRART TNYNSSRSRF YSGFNSRPRG RVYRGRARAT

SWYSPY

Isoforms

- Isoform 2 of Polyadenylate-binding protein 2

Sequence View

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Protein Neighborhood

Domains & Features

18 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86U42-2-unknown	MAAAAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86U42-2-unknown	MAAAAA...	1			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q86U42-2-unknown	MAAAAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169294
Q86U42-1-unknown	MAAAAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84134
Q86U42-2-Acetylation	AAAAAA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86U42-2-Acetylation	AAAAAA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q86U42-2-Acetylation	AAAAAA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q86U42-2-Acetylation	AAAAAA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q86U42-2-Acetylation	AAAAAA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110033
Q86U42-2-	AAAAAA...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q86U42-2-	AAAAAA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86U42-3-acetylation	AAAAAA...	3	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q86U42-3-acetylation	AAAAAA...	3	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163342
Q86U42-3-	AAAAAA...	3			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86U42-3-unknown	AAAAAA...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172322
Q86U42-49-unknown	GLESEE...	49		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173449
Q86U42-49-	GLESEE...	49			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86U42-49-	GLESEE...	49			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86U42-55-unknown	LEPEEL...	55		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q86U42-55-unknown	LEPEEL...	55		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196222
Q86U42-103-	GLVEGD...	103			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86U42-103-unknown	GLVEGD...	103		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173451
Q86U42-112-unknown	GAIEDP...	112			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q86U42-112-unknown	GAIEDP...	112		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161915
Q86U42-112-	GAIEDP...	112			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q86U42-112-	GAIEDP...	112			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q86U42-112-	GAIEDP...	112			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86U42-112-	GAIEDP...	112			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q86U42-112-	GAIEDP...	112			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q86U42-112-	GAIEDP...	112			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86U42-112-	GAIEDP...	112			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q86U42-113-unknown	AIEDPE...	113		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173453
Q86U42-113-	AIEDPE...	113			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86U42-113-	AIEDPE...	113			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86U42-116-unknown	DPELEA...	116		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18017
Q86U42-116-unknown	DPELEA...	116		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19666
Q86U42-116-unknown	DPELEA...	116		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143277
Q86U42-162-unknown	SIEEKM...	162		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14685
Q86U42-162-unknown	SIEEKM...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145218

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DGAIED	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18017
...DGAIED	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19666
...DGAIED	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126507
...GPVIMS	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14685
...GPVIMS	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128507
...WYSPY	306	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	115	AIED.\|.DPEL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	115	AIED.\|.DPEL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	161	VIMS.\|.SIEE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)