P31040: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Protein names | - Succinate dehydrogenase ubiquinone] flavoprotein subunit, mitochondrial - 1.3.5.1 {ECO:0000305|PubMed:24781757} - Flavoprotein subunit of complex II - Fp |
---|---|
Gene names | SDHA |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P31040 |
11
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSGVRGLSRL LSARRLALAK AWPTVLQTGT RGFHFTVDGN KRASAKVSDS ISAQYPVVDH
70 80 90 100 110 120
EFDAVVVGAG GAGLRAAFGL SEAGFNTACV TKLFPTRSHT VAAQGGINAA LGNMEEDNWR
130 140 150 160 170 180
WHFYDTVKGS DWLGDQDAIH YMTEQAPAAV VELENYGMPF SRTEDGKIYQ RAFGGQSLKF
190 200 210 220 230 240
GKGGQAHRCC CVADRTGHSL LHTLYGRSLR YDTSYFVEYF ALDLLMENGE CRGVIALCIE
250 260 270 280 290 300
DGSIHRIRAK NTVVATGGYG RTYFSCTSAH TSTGDGTAMI TRAGLPCQDL EFVQFHPTGI
310 320 330 340 350 360
YGAGCLITEG CRGEGGILIN SQGERFMERY APVAKDLASR DVVSRSMTLE IREGRGCGPE
370 380 390 400 410 420
KDHVYLQLHH LPPEQLATRL PGISETAMIF AGVDVTKEPI PVLPTVHYNM GGIPTNYKGQ
430 440 450 460 470 480
VLRHVNGQDQ IVPGLYACGE AACASVHGAN RLGANSLLDL VVFGRACALS IEESCRPGDK
490 500 510 520 530 540
VPPIKPNAGE ESVMNLDKLR FADGSIRTSE LRLSMQKSMQ NHAAVFRVGS VLQEGCGKIS
550 560 570 580 590 600
KLYGDLKHLK TFDRGMVWNT DLVETLELQN LMLCALQTIY GAEARKESRG AHAREDYKVR
610 620 630 640 650 660
IDEYDYSKPI QGQQKKPFEE HWRKHTLSYV DVGTGKVTLE YRPVIDKTLN EADCATVPPA
IRSY
Isoforms
- Isoform 2 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial - Isoform 3 of Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialSequence View
10 20 30 40 50 60
MSGVRGLSRL LSARRLALAK AWPTVLQTGT RGFHFTVDGN KRASAKVSDS ISAQYPVVDH
70 80 90 100 110 120
EFDAVVVGAG GAGLRAAFGL SEAGFNTACV TKLFPTRSHT VAAQGGINAA LGNMEEDNWR
130 140 150 160 170 180
WHFYDTVKGS DWLGDQDAIH YMTEQAPAAV VELENYGMPF SRTEDGKIYQ RAFGGQSLKF
190 200 210 220 230 240
GKGGQAHRCC CVADRTGHSL LHTLYGRSLR YDTSYFVEYF ALDLLMENGE CRGVIALCIE
250 260 270 280 290 300
DGSIHRIRAK NTVVATGGYG RTYFSCTSAH TSTGDGTAMI TRAGLPCQDL EFVQFHPTGI
310 320 330 340 350 360
YGAGCLITEG CRGEGGILIN SQGERFMERY APVAKDLASR DVVSRSMTLE IREGRGCGPE
370 380 390 400 410 420
KDHVYLQLHH LPPEQLATRL PGISETAMIF AGVDVTKEPI PVLPTVHYNM GGIPTNYKGQ
430 440 450 460 470 480
VLRHVNGQDQ IVPGLYACGE AACASVHGAN RLGANSLLDL VVFGRACALS IEESCRPGDK
490 500 510 520 530 540
VPPIKPNAGE ESVMNLDKLR FADGSIRTSE LRLSMQKSMQ NHAAVFRVGS VLQEGCGKIS
550 560 570 580 590 600
KLYGDLKHLK TFDRGMVWNT DLVETLELQN LMLCALQTIY GAEARKESRG AHAREDYKVR
610 620 630 640 650 660
IDEYDYSKPI QGQQKKPFEE HWRKHTLSYV DVGTGKVTLE YRPVIDKTLN EADCATVPPA
IRSY
10 20 30 40 50 60
MSGVRGLSRL LSARRLALAK AWPTVLQTGT RGFHFTVDGN KRASAKVSDS ISAQYPVVDH
70 80 90 100 110 120
EFDAVVVGAG GAGLRAAFGL SEAGFNTACV TKLFPTRSHT VAAQGGINAA LGNMEEDNWR
130 140 150 160 170 180
WHFYDTVKGS DWLGDQDAIH YMTEQAPAAV VELENYGMPF SRTEDGKIYQ RAFGGQSLKF
190 200 210 220 230 240
GKGGQAHRCC CVADRTGHSL LHTLYGRSLR YDTSYFVEYF ALDLLMENGE CRGVIALCIE
250 260 270 280 290 300
DGSIHRIRAK NTVVATGGYG RTYFSCTSAH TSTGDGTAMI TRAGLPCQDL EFVQFHPTGI
310 320 330 340 350 360
YGAGCLITEG CRGEGGILIN SQGERFMERY APVAKDLASR DVVSRSMTLE IREGRGCGPE
370 380 390 400 410 420
KDHVYLQLHH LPPEQLATRL PGISETAMIF AGVDVTKEPI PVLPTVHYNM GGIPTNYKGQ
430 440 450 460 470 480
VLRHVNGQDQ IVPGLYACGE AACASVHGAN RLGANSLLDL VVFGRACALS IEESCRPGDK
490 500 510 520 530 540
VPPIKPNAGE ESVMNLDKLR FADGSIRTSE LRLSMQKSMQ NHAAVFRVGS VLQEGCGKIS
550 560 570 580 590 600
KLYGDLKHLK TFDRGMVWNT DLVETLELQN LMLCALQTIY GAEARKESRG AHAREDYKVR
610 620 630 640 650 660
IDEYDYSKPI QGQQKKPFEE HWRKHTLSYV DVGTGKVTLE YRPVIDKTLN EADCATVPPA
IRSY
Protein Neighborhood
Domains & Features
11 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P31040-33-unknown | FHFTVD... | 33 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P31040-33- | FHFTVD... | 33 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P31040-33- | FHFTVD... | 33 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P31040-33- | FHFTVD... | 33 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P31040-33- | FHFTVD... | 33 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P31040-33- | FHFTVD... | 33 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P31040-44-unknown | SAKVSD... | 44 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P31040-44-unknown | SAKVSD... | 44 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
P31040-44- | SAKVSD... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P31040-44- | SAKVSD... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P31040-44- | SAKVSD... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P31040-44- | SAKVSD... | 44 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P31040-44- | SAKVSD... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P31040-44- | SAKVSD... | 44 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P31040-63-unknown | DAVVVG... | 63 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19032 | |||
P31040-197-unknown | GHSLLH... | 197 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P31040-268-unknown | SAHTST... | 268 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7420 | |||
P31040-438- | CGEAAC... | 438 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P31040-470- | SIEESC... | 470 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P31040-555-unknown | GMVWNT... | 555 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000421911 | |||
P31040-605-unknown | DYSKPI... | 605 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19033 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...VDHEFD | 62 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19032 | |||
...YFSCTS | 267 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7420 | |||
...RIDEYD | 604 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19033 | |||
...AIRSY | 664 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MEP1B_HUMAN | 62 | HEFD.|.DAVV | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
CATS_HUMAN | 267 | SCTS.|.SAHT | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
MEP1B_HUMAN | 604 | DEYD.|.DYSK | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|