Q15181: Inorganic pyrophosphatase

General Information

Protein names	- Inorganic pyrophosphatase - 3.6.1.1 - Pyrophosphate phospho-hydrolase - PPase
Gene names	PPA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15181

18 N-termini

12 C-termini

15 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGFSTEERA APFSLEYRVF LKNEKGQYIS PFHDIPIYAD KDVFHMVVEV PRWSNAKMEI
        70         80         90        100        110        120
ATKDPLNPIK QDVKKGKLRY VANLFPYKGY IWNYGAIPQT WEDPGHNDKH TGCCGDNDPI
       130        140        150        160        170        180
DVCEIGSKVC ARGEIIGVKV LGILAMIDEG ETDWKVIAIN VDDPDAANYN DINDVKRLKP
       190        200        210        220        230        240
GYLEATVDWF RRYKVPDGKP ENEFAFNAEF KDKDFAIDII KSTHDHWKAL VTKKTNGKGI
       250        260        270        280
SCMNTTLSES PFKCDPDAAR AIVDALPPPC ESACTVPTDV DKWFHHQKN

Isoforms

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

18 N-termini - 12 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15181-2-unknown	MSGFST...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15181-2-Acetylation	SGFSTE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15181-2-Acetylation	SGFSTE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q15181-2-Acetylation	SGFSTE...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q15181-2-Acetylation	SGFSTE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15181-2-Acetylation	SGFSTE...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q15181-3-	GFSTEE...	3			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15181-34-unknown	DIPIYA...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17978
Q15181-34-unknown	DIPIYA...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19567
Q15181-40-unknown	DKDVFH...	40		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19568
Q15181-58-	MEIATK...	58			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q15181-58-	MEIATK...	58			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15181-58-	MEIATK...	58			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15181-64-	DPLNPI...	64			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15181-80-	YVANLF...	80			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15181-94-unknown	YGAIPQ...	94		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4067
Q15181-96-unknown	AIPQTW...	96		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6447
Q15181-96-unknown	AIPQTW...	96		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7853
Q15181-118-unknown	DPIDVC...	118		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17979
Q15181-118-unknown	DPIDVC...	118		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19569
Q15181-154-unknown	WKVIAI...	154		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2718
Q15181-154-unknown	WKVIAI...	154		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15181-154-unknown	WKVIAI...	154		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q15181-163-unknown	DPDAAN...	163		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17980
Q15181-163-unknown	DPDAAN...	163		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19570
Q15181-166-	AANYND...	166			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15181-166-	AANYND...	166			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q15181-166-	AANYND...	166			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15181-166-unknown	AANYND...	166		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2719
Q15181-243-unknown	MNTTLS...	243		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4068
Q15181-280-unknown	VDKWFH...	280		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2720
Q15181-282-unknown	KWFHHQ...	282		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2721

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ISPFHD	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17978
...ISPFHD	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19567
...IPIYAD	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19568
...GYIWNY	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4067
...IWNYGA	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6447
...IWNYGA	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7853
...CCGDND	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17979
...CCGDND	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19569
...EGETDW	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2718
...AINVDD	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17980
...AINVDD	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19570
...VDDPDA	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2719
...KGISCM	242	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4068
...TVPTDV	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2720
...PTDVDK	281	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2721
...HHQKN	289	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	33	PFHD.\|.DIPI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	33	PFHD.\|.DIPI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	39	IYAD.\|.DKDV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	93	IWNY.\|.YGAI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	95	NYGA.\|.AIPQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	95	NYGA.\|.AIPQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	117	GDND.\|.DPID	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	117	GDND.\|.DPID	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP6_HUMAN	153	ETDW.\|.WKVI	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
MEP1A_HUMAN	162	NVDD.\|.DPDA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	162	NVDD.\|.DPDA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP6_HUMAN	165	DPDA.\|.AANY	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CATB_HUMAN	242	ISCM.\|.MNTT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP6_HUMAN	279	PTDV.\|.VDKW	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	281	DVDK.\|.KWFH	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)