P48643: T-complex protein 1 subunit epsilon

General Information

Protein names	- T-complex protein 1 subunit epsilon - TCP-1-epsilon - CCT-epsilon
Gene names	CCT5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P48643

15 N-termini

5 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASMGTLAFD EYGRPFLIIK DQDRKSRLMG LEALKSHIMA AKAVANTMRT SLGPNGLDKM
        70         80         90        100        110        120
MVDKDGDVTV TNDGATILSM MDVDHQIAKL MVELSKSQDD EIGDGTTGVV VLAGALLEEA
       130        140        150        160        170        180
EQLLDRGIHP IRIADGYEQA ARVAIEHLDK ISDSVLVDIK DTEPLIQTAK TTLGSKVVNS
       190        200        210        220        230        240
CHRQMAEIAV NAVLTVADME RRDVDFELIK VEGKVGGRLE DTKLIKGVIV DKDFSHPQMP
       250        260        270        280        290        300
KKVEDAKIAI LTCPFEPPKP KTKHKLDVTS VEDYKALQKY EKEKFEEMIQ QIKETGANLA
       310        320        330        340        350        360
ICQWGFDDEA NHLLLQNNLP AVRWVGGPEI ELIAIATGGR IVPRFSELTA EKLGFAGLVQ
       370        380        390        400        410        420
EISFGTTKDK MLVIEQCKNS RAVTIFIRGG NKMIIEEAKR SLHDALCVIR NLIRDNRVVY
       430        440        450        460        470        480
GGGAAEISCA LAVSQEADKC PTLEQYAMRA FADALEVIPM ALSENSGMNP IQTMTEVRAR
       490        500        510        520        530        540
QVKEMNPALG IDCLHKGTND MKQQHVIETL IGKKQQISLA TQMVRMILKI DDIRKPGESE

E

Isoforms

- Isoform 2 of T-complex protein 1 subunit epsilon

Sequence View

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Protein Neighborhood

Domains & Features

15 N-termini - 5 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P48643-2-unknown	MASMGT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P48643-2-Acetylation	ASMGTL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P48643-2-Acetylation	ASMGTL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P48643-2-Acetylation	ASMGTL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P48643-2-Acetylation	ASMGTL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P48643-2-Acetylation	ASMGTL...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P48643-39-unknown	MAAKAV...	39		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000427297
P48643-66-	GDVTVT...	66			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P48643-82-unknown	DVDHQI...	82		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7483
P48643-154-	SVLVDI...	154			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P48643-154-unknown	SVLVDI...	154		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170771
P48643-192-	AVLTVA...	192			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P48643-192-	AVLTVA...	192			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P48643-192-	AVLTVA...	192			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P48643-192-unknown	AVLTVA...	192		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170773
P48643-233-unknown	DFSHPQ...	233		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19132
P48643-233-unknown	DFSHPQ...	233		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144319
P48643-253-unknown	CPFEPP...	253		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7484
P48643-253-unknown	CPFEPP...	253		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19134
P48643-253-unknown	CPFEPP...	253		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145130
P48643-264-	HKLDVT...	264			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P48643-264-	HKLDVT...	264			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P48643-264-	HKLDVT...	264			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P48643-264-	HKLDVT...	264			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P48643-264-	HKLDVT...	264			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P48643-264-unknown	HKLDVT...	264		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164617
P48643-310-acetylation	ANHLLL...	310	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P48643-310-acetylation	ANHLLL...	310	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182740
P48643-486-unknown	NPALGI...	486		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17664
P48643-486-unknown	NPALGI...	486		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19136
P48643-486-unknown	NPALGI...	486		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151884

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ILSMMD	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7483
...VIVDKD	232	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19132
...VIVDKD	232	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127581
...IAILTC	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7484
...IAILTC	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19134
...IAILTC	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128416
...QVKEMN	485	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17664
...QVKEMN	485	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19136
...QVKEMN	485	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135289
...GESEE	541	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GESEE	541	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87370

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	81	SMMD.\|.DVDH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	232	VDKD.\|.DFSH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	252	ILTC.\|.CPFE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	252	ILTC.\|.CPFE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	485	KEMN.\|.NPAL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	485	KEMN.\|.NPAL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)