Q13765: Nascent polypeptide-associated complex subunit alpha

General Information

Protein names	- Nascent polypeptide-associated complex subunit alpha - NAC-alpha - Alpha-NAC - Hom s 2
Gene names	NACA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13765

13 N-termini

8 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPGEATETVP ATEQELPQPQ AETGSGTESD SDESVPELEE QDSTQATTQQ AQLAAAAEID
        70         80         90        100        110        120
EEPVSKAKQS RSEKKARKAM SKLGLRQVTG VTRVTIRKSK NILFVITKPD VYKSPASDTY
       130        140        150        160        170        180
IVFGEAKIED LSQQAQLAAA EKFKVQGEAV SNIQENTQTP TVQEESEEEE VDETGVEVKD
       190        200        210
IELVMSQANV SRAKAVRALK NNSNDIVNAI MELTM

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

13 N-termini - 8 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13765-1-unknown	MPGEAT...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13765-43-	STQATT...	43		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13765-43-	STQATT...	43		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13765-43-	STQATT...	43		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13765-51-	AQLAAA...	51		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13765-51-	AQLAAA...	51		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13765-51-	AQLAAA...	51		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q13765-51-	AQLAAA...	51		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13765-52-	QLAAAA...	52		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13765-53-	LAAAAE...	53		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13765-53-	LAAAAE...	53		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13765-53-	LAAAAE...	53		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13765-54-	AAAAEI...	54		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13765-54-	AAAAEI...	54		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13765-54-	AAAAEI...	54		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13765-54-	AAAAEI...	54		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13765-54-	AAAAEI...	54		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13765-54-	AAAAEI...	54		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13765-55-	AAAEID...	55		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13765-55-	AAAEID...	55		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13765-55-	AAAEID...	55		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13765-55-	AAAEID...	55		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13765-55-	AAAEID...	55		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13765-55-	AAAEID...	55		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13765-55-	AAAEID...	55		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13765-55-	AAAEID...	55		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13765-55-	AAAEID...	55		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q13765-55-	AAAEID...	55		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13765-55-unknown	AAAEID...	55	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19474
Q13765-55-unknown	AAAEID...	55	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17919
Q13765-55-unknown	AAAEID...	55		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13765-56-unknown	AAEIDE...	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17920
Q13765-56-unknown	AAEIDE...	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19475
Q13765-56-unknown	AAEIDE...	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14465
Q13765-56-	AAEIDE...	56		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13765-56-	AAEIDE...	56		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13765-56-	AAEIDE...	56		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13765-56-	AAEIDE...	56		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13765-57-unknown	AEIDEE...	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17921
Q13765-57-unknown	AEIDEE...	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19476
Q13765-59-unknown	IDEEPV...	59	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12110
Q13765-61-unknown	EEPVSK...	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12111

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...QAQLAA	54	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19474
...QAQLAA	54	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17919
...AQLAAA	55	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17920
...AQLAAA	55	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19475
...AQLAAA	55	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14465
...QLAAAA	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17921
...QLAAAA	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19476
...AAAAEI	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12110
...AAEIDE	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12111
...IMELTM	214	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8235
...MELTM	215		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...MELTM	215		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...MELTM	215	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...MELTM	215		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...MELTM	215		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	54	QLAA.\|.AAAE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	54	QLAA.\|.AAAE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	55	LAAA.\|.AAEI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	55	LAAA.\|.AAEI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	55	LAAA.\|.AAEI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	56	AAAA.\|.AEID	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	56	AAAA.\|.AEID	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	58	AAEI.\|.IDEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	60	EIDE.\|.EEPV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CBPA4_HUMAN	214	ELTM.\|.M	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)